In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

Autor: Isobel Douglas, Remi Villenave, Ultan F. Power, Liam G Heaney, Surendran Thavagnanam, Peter V. Coyle, Grzegorz Skibinski, JC Parker, James P. McKaigue, Severine Sarlang, Michael D. Shields

Publikováno v: Proceedings of the National Academy of Sciences. 109:5040-5045

Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, the mechanisms by which RSV causes disease in humans remain poorly understood. To help bridge this gap, we developed an ex viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42457e83484a8c6fb8bc4a6802541de7
https://doi.org/10.1073/pnas.1110203109

Cytopathogenesis of Sendai Virus in Well-Differentiated Primary Pediatric Bronchial Epithelial Cells

Autor: Ultan F. Power, Severine Sarlang, James P. McKaigue, Peter V. Coyle, Olivier Touzelet, Surendran Thavagnanam, Grzegorz Skibinski, Michael D. Shields, Remi Villenave, Liam G Heaney, JC Parker

Publikováno v: Journal of Virology. 84:11718-11728

Sendai virus (SeV) is a murine respiratory virus of considerable interest as a gene therapy or vaccine vector, as it is considered nonpathogenic in humans. However, little is known about its interaction with the human respiratory tract. To address th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906e082d25053b71773fa64e86ad2dc4
https://doi.org/10.1128/jvi.00798-10

Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model

Autor: Michael D. Shields, Jeremy Lyons, Surendran Thavagnanam, Liam G Heaney, Grzegorz Skibinski, JC Parker, Jennifer M Bell

Publikováno v: Parker, J C, Thavagnanam, S, Skibinski, G, Lyons, J, Bell, J, Heaney, L G & Shields, M D 2013, ' Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model ', PloS one, vol. 8, no. 5, e61023 . https://doi.org/10.1371/journal.pone.0061023
PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e61023 (2013)

Asthma is a chronic inflammatory disease characterised by airways remodelling. In mouse models IL-9 and IL-13 have been implicated in airways remodelling including mucus hypersecretion and goblet cell hyperplasia. Their role, especially that of IL-9,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432b6c70d804b2111673b1138c4f26d3
https://pure.qub.ac.uk/en/publications/chronic-il9-and-il13-exposure-leads-to-an-altered-differentiation-of-ciliated-cells-in-a-welldifferentiated-paediatric-bronchial-epithelial-cell-model(94b90b9a-9125-453f-9432-64e10b828732).html

Effects of IL-13 on mucociliary differentiation of pediatric asthmatic bronchial epithelial cells

Autor: Michael D. Shields, Liam G Heaney, Michael E. McBrien, JC Parker, Surendran Thavagnanam, Grzegorz Skibinski

Publikováno v: Pediatric research. 69(2)

Goblet cell hyperplasia (GCH) and decreased ciliated cells are characteristic of asthma. We examined the effects of IL-13 (2 and 20 ng/mL) on in vitro mucociliary differentiation in pediatric bronchial epithelial cells (PBECs) of normal PBEC [PBEC(N)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9601b5973d9d930917c47ba59ee69387
https://pubmed.ncbi.nlm.nih.gov/21076368

Metabolic effects of sub-chronic ablation of the incretin receptors by daily administration of (Pro3)GIP and exendin(9–39)amide in obese diabetic (ob/ob) mice

Autor: Victor A. Gault, Finbarr O'Harte, Peter R. Flatt, Nigel Irwin, K.S. Lavery, JC Parker, Brian D. Green

Publikováno v: Biological Chemistry. 388

Effects of chemical ablation of the GIP and GLP-1 receptors on metabolic aspects of obesity-diabetes were investigated using the stable receptor antagonists (Pro(3))GIP and exendin(9-39)amide. Ob/ob mice received a daily i.p. injection of saline vehi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ceaaf1715c2c66af58ae7de9dd6dc06
https://doi.org/10.1515/bc.2007.024