Zobrazeno 1 - 10 of 2 261 pro vyhledávání: '"JC Parker"'
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Akademický článek
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In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo
Autor: Isobel Douglas, Remi Villenave, Ultan F. Power, Liam G Heaney, Surendran Thavagnanam, Peter V. Coyle, Grzegorz Skibinski, JC Parker, James P. McKaigue, Severine Sarlang, Michael D. Shields
Publikováno v: Proceedings of the National Academy of Sciences. 109:5040-5045
Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, the mechanisms by which RSV causes disease in humans remain poorly understood. To help bridge this gap, we developed an ex viv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42457e83484a8c6fb8bc4a6802541de7
https://doi.org/10.1073/pnas.1110203109
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3
IL-31 does not induce normal human ciliated epithelial cells to differentiate into a phenotype consistent with the pathophysiology of asthma
Autor: Liam G Heaney, Michael E. McBrien, Grzegorz Skibinski, JC Parker, Michael D. Shields, Surendran Thavagnanam
Publikováno v: Results in Immunology. 2:104-111
BackgroundIL-31 is a novel cytokine that has been implicated in allergic diseases such as atopic dermatitis and more recently asthma. While IL-31 has been well studied in skin conditions such as atopic dermatitis, little is known about the role IL-31
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0e414cfe5c88ea7f7cafa9dbcad9d8
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4
Cytopathogenesis of Sendai Virus in Well-Differentiated Primary Pediatric Bronchial Epithelial Cells
Autor: Ultan F. Power, Severine Sarlang, James P. McKaigue, Peter V. Coyle, Olivier Touzelet, Surendran Thavagnanam, Grzegorz Skibinski, Michael D. Shields, Remi Villenave, Liam G Heaney, JC Parker
Publikováno v: Journal of Virology. 84:11718-11728
Sendai virus (SeV) is a murine respiratory virus of considerable interest as a gene therapy or vaccine vector, as it is considered nonpathogenic in humans. However, little is known about its interaction with the human respiratory tract. To address th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906e082d25053b71773fa64e86ad2dc4
https://doi.org/10.1128/jvi.00798-10
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6
Akademický článek
Age-related testosterone decline: mechanisms and intervention strategies.
Autor: Cheng, Haoyang1 (AUTHOR), Zhang, Xiaoyan2 (AUTHOR), Li, Yongheng3 (AUTHOR), Cao, Dezhong4 (AUTHOR), Luo, Chenglong1 (AUTHOR), Zhang, Qi1 (AUTHOR), Zhang, Sizheng1 (AUTHOR), Jiao, Yongzheng1,5 (AUTHOR) yzhjiao@126.com
Publikováno v: Reproductive Biology & Endocrinology. 11/14/2024, Vol. 22 Issue 1, p1-14. 14p.
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7
Akademický článek
Structures of the mycobacterial MmpL4 and MmpL5 transporters provide insights into their role in siderophore export and iron acquisition.
Autor: Maharjan, Rakesh1 (AUTHOR), Zhang, Zhemin1 (AUTHOR), Klenotic, Philip A.1 (AUTHOR), Gregor, William D.1 (AUTHOR), Tringides, Marios L.1 (AUTHOR), Cui, Meng2 (AUTHOR), Purdy, Georgiana E.3 (AUTHOR), Yu, Edward W.1 (AUTHOR) edward.w.yu@case.edu
Publikováno v: PLoS Biology. 10/18/2024, Vol. 22 Issue 10, p1-19. 19p.
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8
Nasal Epithelial Cells Can Act as a Physiological Surrogate for Paediatric Asthma Studies
Autor: Liam G Heaney, Michael E. McBrien, Michael D. Shields, Surendran Thavagnanam, Grzegorz Skibinski, JC Parker
Publikováno v: PLoS ONE
Thavagnanam, S, Parker, J C, McBrien, M E, Skibinski, G, Shields, M D & Heaney, L G 2014, ' Nasal Epithelial Cells Can Act as a Physiological Surrogate for Paediatric Asthma Studies ', PLoS ONE, vol. 9, no. 1, e85802 . https://doi.org/10.1371/journal.pone.0085802
PLoS ONE, Vol 9, Iss 1, p e85802 (2014)
Introduction: Differentiated paediatric epithelial cells can be used to study the role of epithelial cells in asthma. Nasal epithelial cells are easier to obtain and may act as a surrogate for bronchial epithelium in asthma studies. We assessed the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924b5e4017c28d96b26b93fa81d1e584
http://europepmc.org/articles/PMC3903489
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9
Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model
Autor: Michael D. Shields, Jeremy Lyons, Surendran Thavagnanam, Liam G Heaney, Grzegorz Skibinski, JC Parker, Jennifer M Bell
Publikováno v: Parker, J C, Thavagnanam, S, Skibinski, G, Lyons, J, Bell, J, Heaney, L G & Shields, M D 2013, ' Chronic IL9 and IL-13 Exposure Leads to an Altered Differentiation of Ciliated Cells in a Well-Differentiated Paediatric Bronchial Epithelial Cell Model ', PloS one, vol. 8, no. 5, e61023 . https://doi.org/10.1371/journal.pone.0061023
PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e61023 (2013)
Asthma is a chronic inflammatory disease characterised by airways remodelling. In mouse models IL-9 and IL-13 have been implicated in airways remodelling including mucus hypersecretion and goblet cell hyperplasia. Their role, especially that of IL-9,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432b6c70d804b2111673b1138c4f26d3
https://pure.qub.ac.uk/en/publications/chronic-il9-and-il13-exposure-leads-to-an-altered-differentiation-of-ciliated-cells-in-a-welldifferentiated-paediatric-bronchial-epithelial-cell-model(94b90b9a-9125-453f-9432-64e10b828732).html
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