SAT0435 IL17 correlates positively with TGF-BETA 1 and DKK1 and inversely with BMP2 and 4 in synovial membrane of patients with psoriatic arthritis

Autor: JC Fernandez-Lopez, F. Blanco-García, M Bejerano-Herrería, J Pinto-Tasende, B Acasuso-Pardo de Vera, M.E. Vázquez-Mosquera, N. Oreiro-Villar, Mercedes Fernández-Moreno

Publikováno v: Poster Presentations.

Background Immune and non-immune cells contribute to the pathology of chronic arthritis and they can contribute to tissue remodeling and repair as well as disease pathogenesis. An important role for their products such as TGF-beta 1, IL17 or BMPs has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27c029c7d56ea91a1bce40c7ca4e17f4
https://doi.org/10.1136/annrheumdis-2017-eular.4427

Author Correction: The power of genetic diversity in genome-wide association studies of lipids.

Autor: Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Clarke SL; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Zajac GJM; Department of Biostatistics and Center for Statistics Genetics, University of Michigan, Ann Arbor, MI, USA., Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Vedantam S; Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St Louis, MO, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hwang MY; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Han S; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ekoru K; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Trivedi B; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Martin HC; Wellcome Sanger Institute, Hinxton, UK., Hunt KA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; Malcolm Randall VA Medical Center, Gainesville, FL, USA.; Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhu X; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Statistics, The Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA., Thorleifsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Helgadottir A; deCODE genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali-National University Hospital of Iceland, Reykjavik, Iceland., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sakaue S; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kanai M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Thoracic Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Veturi Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Lingren T; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pacheco JA; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA., Pendergrass SA; Genentech, South San Francisco, CA, USA., Haessler J; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Miller JE; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK., Yu K; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge Strangeways Research Laboratory, Cambridge, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Yoon K; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Willemsen G; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Gao Z; Department of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, China.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Bristol Dental School, University of Bristol, Bristol, UK., Mitchell RE; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Sabater-Lleal M; Group of Genomics of Complex Diseases, Research Institute of Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Sidore C; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari,, Italy., Fiorillo E; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Lanusei, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Thuesen BH; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck, Germany.; Charité-University Medicine Berlin, Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Periodontology and Synoptic Dentistry, Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang B; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Poveda A; Lund University Diabetes Centre, Malmo, Sweden., Kurbasic A; Lund University Diabetes Centre, Malmo, Sweden., Lamina C; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Innsbruck, Austria., Forer L; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Innsbruck, Austria., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Bradfield JP; Quantinuum Research, Wayne, PA, USA., Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Benjamins JW; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, London, UK.; Department of Epidemiology and Public Health, University College London, London, UK., Kember RL; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Lo KS; Montreal Heart Institute, Montreal, Quebec, Canada., Zilhao NR; Icelandic Heart Association, Reykjavik, Iceland., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Institute for Advanced Research, Wenzhou Medical University, Wenzhou, China., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Schmidt B; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., Arendt M; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany.; Department of Computer Science, University of Applied Sciences and Arts Dortmund, Dortmund, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Huerta-Chagoya A; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de Mexico, Mexico, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico, Mexico., Lyssenko V; Center for Diabetes Research, University of Bergen, Bergen, Norway.; Lund University Diabetes Center, Lund University, Malmo, Sweden., Ahmed M; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India., Jackson AU; Department of Biostatistics and Center for Statistics Genetics, University of Michigan, Ann Arbor, MI, USA., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Irvin MR; Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, New South Wales, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, USA., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Prasad G; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Theusch E; Department of Pediatrics, University of California, San Francisco, Oakland, CA,, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA,, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Department of Psychiatry, Washington University, St Louis, MO, USA., Hung YJ; Division of Endocrinology and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan., Chen S; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Liu F; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Brumat M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.; Department of Population Science and Experimental Medicine, University College London, London, UK., Hofer E; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Concas MP; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Lee J; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, NIA, Baltimore, MD, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Lee JY; Oneomics, Bucheon, Korea., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Trust Sanger Institute, Hinxton, UK., Rayner NW; Wellcome Sanger Institute, Hinxton, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Ronne, Denmark., Hildalgo B; School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., van Setten J; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Jackson RD; Division of Endocrinology, Ohio State University, Columbus, OH, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Martin LW; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Highland HM; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, University Hospital Leipzig, Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Giardoglou T; Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kim EK; Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea., Adams HHH; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Asselbergs FW; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kraaijeveld AO; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Sydney, New South Wales, Australia., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.; Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia., Mori TA; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Lee H; Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, MD, USA., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, MD, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Chen YE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Bandinelli S; Local Health Unit Toscana Centro, Firenze, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Jung B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, Diabetology, Rheumatology, Traunstein Hospital, Traunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Mamakou V; Medical School, National and Kapodistrian University Athens, Athens, Greece.; Dromokaiteio Psychiatric Hospital, Athens, Greece., Brown M; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Krauss RM; Departments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., den Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Penninx B; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Korea., Attia J; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA., Arnett DK; University of Kentucky, College of Public Health, Lexington, KY, USA., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Newcastle upon Tyne, UK., Koistinen HA; Department of Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Chandak GR; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Yajnik CS; Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India., Mercader JM; Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico, Mexico.; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Bimédicas UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Villalpando CG; Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes, Cuernavaca, Mexico., Orozco L; Instituto Nacional de Medicina Genómica, Mexico, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Yokota M; Kurume University School of Medicine, Kurume, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme, Kenilworth, NJ, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Jöckel KH; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Genentech, South San Francisco, CA, USA.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Simonsick E; Intramural Research Program, National Institute on Aging, Baltimore, MD, USA., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lu F; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, Mexico., Gudnason V; Icelandic Heart Association, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medecine, Université de Montréal, Quebec, Quebec, Canada., Lettre G; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., 't Hart LM; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Elders PJM; Amsterdam UMC, Department of General Practice and Elderly Care, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Damrauer SM; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Kumari M; Institute of Social and Economic Research, University of Essex, Essex, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., van der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanent Washington Health Research Institute, Seattle, WA, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense, Denmark., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Widén E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Grant SFA; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kiemeney LALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., de Graaf J; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Kronenberg F; German Chronic Kidney Disease Study, Innsbruck, Austria.; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Gu D; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany., Schunkert H; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., Partner site Munich Heart Alliance, Munich, Germany., Franks PW; Lund University Diabetes Centre, Malmo, Sweden., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Khera AV; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program of Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Männikkö M; Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter of Oulu, University of Oulu, Oulu, Finland., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Center for Primary Care and Public Health, Lausanne, Switzerland., Cucca F; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy.; 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Publikováno v: Nature [Nature] 2023 Jun; Vol. 618 (7965), pp. E19-E20.

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.

Autor: Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhu X; Department of Statistics, The Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA., Clarke SL; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Vedantam S; Boston Children's Hospital, EndocrinologyBoston, MA, 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St. Louis, MO, 63108, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Zajac GJM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA., Hilliard AT; VA Palo Alto Health Care Systems, Palo Alto, CA, USA., Wang Z; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Thorleifsson G; deCODE Genetics/Amgen, Inc. 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Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. 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Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Gao Z; Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Bristol Dental School, University of Bristol, Lower Maudlin Street, Bristol, BS1 2LY, UK., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Mitchell RE; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bjerregaard AA; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22903, USA., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Hung YJ; Institute of Preventive Medicine, National Defense Medical Center, Postbox 90048~700, Sanhsia Dist, New Taipei City, 237101, Taiwan., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; Aragon Institute of Engineering Research, University of Zaragoza and Centro de Investigación Biomédica en Red - Bioingeniería, Biomateriales Y Nanomedicina, Spain., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Mauro P; Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy., Matteo F; Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche, Rome, Italy.; Dipartimento Di Scienze Biomediche, Università Degli Studi Di Sassari, Sardinia, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Dept of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité - University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Yang B; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Poveda A; Lund University Diabetes Center, Lund University, Malmö, Sweden., Kurbasic A; Lund University Diabetes Center, Lund University, Malmö, Sweden., Lamina C; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Forer L; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Bradfield JP; Quantinuum Research LLC, Wayne, PA, 19087, USA., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Daw E; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA., Vazquez-Moreno M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Benjamins JW; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, Gower Street, London, WC1E 6BT, UK.; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK., Tsao NL; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Lo KS; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Zilhao NR; Icelandic Heart Association, 201, Kopavogur, Iceland., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim GmbH, 68163, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Yang J; School of Life Sciences, Westlake University, Hangzhou, 310024, Zhejiang, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, 310024, Zhejiang, China.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, Surrey, UK., Leonard HL; Laboratory of Neurogenetics, National Institute On Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Frank M; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., Schmidt B; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland.; Genomic Oncology Area, GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada-Andalusian Regional Government, Granada, Spain.; Hematology Department, Hospital Universitario Virgen de Las Nieves, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), Granada, Spain., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, 461-8673, Japan., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK., Hutri-Kähönen N; Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Huerta-Chagoya A; CONACYT, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Ciudad de Mexico, Mexico.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Departamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Coyoacán, 04510, Mexico City, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Lyssenko V; Lund University Diabetes Center, Lund University, Malmö, Sweden.; Center for Diabetes Research, University of Bergen, Bergen, Norway., Nongmaithem SS; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Bayyana S; Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, India.; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Stringham HM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Irvin MR; Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea.; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, 06355, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 04514, Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 03181, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Duke-NUS Medical School, Health Services and Systems Research, Singapore, 169857, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, 80045, USA., Prasad G; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, 110020, India.; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Theusch E; Department of Pediatrics, University of California San Francisco, Oakland, CA, 94609, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA, 01003, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, Dong Cheng District, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Chen S; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Liu F; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Banas B; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany., Nardone GG; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.; Department of Clinical Epidemiology, Institute of Health Informatics, University College London, London, UK., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Massachusetts General Hospital Cancer Center, Charlestown, MA, 02129, USA., Concas MP; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA.; Department of Engineering Technology, University of Houston-Sugarland, Houston, TX, USA., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Bentley AR; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Doumatey AP; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Adeyemo AA; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Lee JY; Oneomics. Co. Ltd. 2F, Soonchunhyang Mirai Medical Center 173, Buheuyng-Ro, Bucheon-Si Gyeonggi-Do, 14585, Korea., Petersen ERB; Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Kresten Philipsens Vej 15, 6200, Aabenraa, Denmark., Nielsen AA; Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Rayner NW; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Québec, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, 33521, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Kent St, Woolloongabba, Brisbane, QLD, 4102, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Hidalgo B; Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands., van Setten J; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Liang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Tang H; Department of Genetics, Stanford University School of Medicine Stanford, Palo Alto, CA, 94305, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Jackson RD; Division of Endocrinology, Ohio State University, Columbus, OH, 43210, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, 98195, USA., Martin LW; School of Medicine and Health Sciences, George Washington University, Washington, DC, 20037, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; Institute for Laboratory Medicine, University Hospital Leipzig, Paul-List-Strasse 13/15, 04103, Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH, Baltimore, MD, 20892-9205, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Center for Alzheimer's and Related Dementias, NIH, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, 329-0498, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, 6938501, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia., Kovacs P; University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany., Giardoglou T; Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, 17676, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, 5650871, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, 5650871, Japan., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kim EK; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital, SeoulIlsan, 03722, Korea., Adams HHH; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Dept of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA., Asselbergs FW; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kraaijeveld AO; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam, 1081HV, the Netherlands.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, 3584CG, Utrecht, the Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Hawkesbury Rd, Sydney, NSW, 2145, Australia., Hewitt AW; School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Liverpool St, Hobart, TAS, 7000, Australia.; Centre for Eye Research Australia, University of Melbourne, Melbourne, VIC, 3002, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, 33521, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Québec, Canada.; Centre Nutrition, Santé Et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Québec, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Tönjes A; University of Leipzig Medical Center, Liebigstr. 18, 04103, Medical Department III - Endocrinology, Nephrology, RheumatologyLeipzig, Germany., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, 2308, Australia., Mori TA; Discipline of Internal Medicine, Medical School, The University of Western Australia, Perth, WA, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, 24252, Gangwon-Do, Korea., Lee H; Department of Internal Medicine, EwhaWomans University School of Medicine, Seoul, Korea., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15232, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, 117609, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, 02447, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center, NIH 251 Bayview Blvd, Baltimore, MD, 21224, USA., Polasek O; University of Split School of Medicine, Šoltanska 2, HR-21000, Split, Croatia.; Algebra University College, Ilica 242, Zagreb, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Physical Activity and Health, Paavo Nurmi Centre, Sports and Exercise Medicine Unit, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, the Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Bandinelli S; Local Health Unit Toscana Centro, Florence, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA., Kato N; National Center for Global Health and Medicine, Tokyo, 1628655, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada Di Fiume 447, 34149, Trieste, Italy., Böger CA; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, , Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Jung B; Dept of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, , Traunstein Hospital, Diabetology, RheumatologyTraunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Neurology, Center for Translational and Systems Neuroimmunology, Columbia University Medical Center, New York, NY, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China., Mamakou V; Medical School, National and Kapodistrian University Athens, 75 M. Assias Street, 115 27, Athens, Greece.; Dromokaiteio Psychiatric Hospital, 124 61, Athens, Greece., Brown M; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso' - CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chong Wen Men, Beijing, 100005, China.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Kutzerufer 1, 68167, Mannheim, Germany.; Institute of Molecular and Clinical Ophthalmology, Basel, Switzerland.; Privatpraxis Prof Jonas Und Dr Panda-Jonas, Heidelberg, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA., Tusié-Luna T; Unidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán, 14080, Mexico, Mexico., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, 6000, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, 6000, Cebu City, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, 11010, Sri Lanka., Krauss RM; Children's Hospital Oakland Research Institute, Oakland, CA, 94609, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, USA., Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15, Nijmegen, 6525 EX, the Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre, Ghaziabad, Uttar Pradesh, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, 110067, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Penninx B; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands.; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 07804, Korea., Attia J; Hunter Medical Research Institute, Newcastle, Australia.; Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, Australia.; Faculty of Health and Medicine, University of Newcastle, Callaghan, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, USA., Arnett DK; Office of the Provost, University of South Carolina, Columbia, SC, USA., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, 84132, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle Upon Tyne, NE2 4HH, UK., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, P.O.Box 340, 00029, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, 00290, Helsinki, Finland., Chandak GR; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.; JSS Academy of Higher Education and Research, Mysuru, India., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, 02115, USA., Costanzo MC; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jang D; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burtt NP; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Villalpando CG; InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes, Cuernavaca, Mexico., Orozco L; Laboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Tai E; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, 119228, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, 117549, Singapore.; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, 20052, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, 33520, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, 1-19 Torrington Place, London, WC1E 7HB, UK., Yokota M; Kurume University School of Medicine, Kurume, 830-0011, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme Corp., Kenilworth, NJ, 07033, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, Northern Ireland., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, DD1 9SY, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland., Simonsick E; Intramural Research Program, National Institute On Aging, 3001 S. Hanover St., Baltimore, MD, 21225, USA., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Jin ZB; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, 100730, China.; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China., Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd, Tokushima, Japan., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Gudnason V; Icelandic Heart Association, 201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland., Tardif JC; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Lettre G; Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, PQ, H1T1C8, Canada., Hart LM'; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, 1081HV, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam Cardiovascular Sciences, Amsterdam, 1081HV, the Netherlands., Elders PJM; Department of General Practice, Amsterdam UMC, Amsterdam, 1081HV, the Netherlands.; Amsterdam Public Health Research Institute, Health Behaviours and Chronic Diseases, Amsterdam, 1081HV, the Netherlands., Damrauer SM; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, 19104, USA., Kumari M; Institute of Social and Economic Research, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, SE1 7EH, UK., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, L5L 1C6, Canada., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Via Galvani 31, 39100, Bolzano, Italy., Rotimi CN; Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Room 1025, Bethesda, MD, 20892, USA., Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense C, Denmark., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Widén E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Tukholmankatu 8, 00014, Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA., Grant SFA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA., Kiemeney LALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., de Graaf J; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, Germany., Kronenberg F; Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Berlin, Germany., Gu D; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany., Schunkert H; Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany., Franks PW; Lund University Diabetes Center, Lund University, Malmö, Sweden., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Khera AV; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Verve Therapeutics, Cambridge, MA, USA., Männikkö M; Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter of Oulu, University of Oulu, Oulu, Finland., Kutalik Z; University Center for Primary Care and Public Health, University of Lausanne, Rte de Berne 113, 1010, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland., Francesco C; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy.; University of Sassari, Sassari, Italy., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., van Dijk KW; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sever P; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Poulter N; School of Public Health, Imperial College London, London, W12 7RH, UK., Chuang LM; Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Dantoft TM; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Karpe F; OCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Neville MJ; OCDEM, University of Oxford, Churchill Hospital, Oxford, OX3 7LE, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Timpson NJ; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield Grove, Bristol, BS8 2BN, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Li H; Data Science, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 168751, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Deutsches Zentrum Für Herz-Kreislauf-Forschung (DZHK) E.V., Partner Site Munich Heart Alliance, Munich, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Hattersley AT; Medical School, University of Exeter, University of Exeter, Exeter, EX2 5DW, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Willemsen AHM; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam UMC, the Netherlands., Cupples L; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA., van Meurs JBJ; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27599, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, 27516, USA., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin, Berlin, Germany., Zeggini E; Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts Der Isar, TUM School of Medicine, Munich, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, 94305, USA., Abecasis G; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore.; Imperial College Healthcare NHS Trust, Imperial College London, London, W12 0HS, UK., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; School of Public Health, Imperial College London, London, W12 7RH, UK.; Imperial College Healthcare NHS Trust, London, W12 0HS, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, W2 1PG, UK., de Vries PS; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Hazelhurst S; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; School of Electrical and Information Engineering, University of the Witwatersrand, Johannesburg, South Africa., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Daviglus M; Institute for Minority Health Research, University of Illinois College of Medicine, Chicago, IL, USA., Kraft P; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA., Martin NG; QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia., Whitfield JB; QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD, 4006, Australia., Abbas S; Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.; Faisalabad Institute of Cardiology, Faislabad, Pakistan., Saleheen D; Center for Non-Communicable Diseases, Karachi, Sindh, Pakistan.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA., Walters RG; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Big Data Institute, University of Oxford, Oxford, OX3 7LF, UK., Holmes MV; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals, Oxford, UK., Black C; Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK., Baras A; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Justice AE; Department of Population Health Sciences, Geisinger Health, Danville, PA, 17822, USA., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Kooperberg C; Fred Hutchinson Cancer Center, Division of Public Health Sciences, Seattle, WA, 9810, USA., Tamiya G; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., Yamamoto M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan., van Heel DA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Trembath RC; School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Jarvik GP; Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Washington, USA., Namjou B; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA., Hayes MG; Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60618, USA.; Department of Anthropology, Northwestern University, Evanston, IL, 60208, USA., Ritchie MD; Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 19104, USA., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Hveem K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, 7600, Levanger, Norway.; Department of Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Public Health and Nursing, HUNT Research Centre, NTNU, Norwegian University of Science and Technology, 7600, Levanger, Norway.; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Kubo M; RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Murakami Y; Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Chungcheongbuk-Do, South Korea., Thorsteinsdottir U; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.; Faculty of Medicine, University of Iceland, Sæmundargötu 2, Reykjavik, 102, Iceland., Stefansson K; deCODE Genetics/Amgen, Inc. Sturlugata 8, Reykjavik, 102, Iceland.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Chen Y; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Ho YL; VA Boston Healthcare System, Boston, MA, USA., Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; University of Massachusetts, Boston, MA, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Tsao PS; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Cho K; VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA., O'Donnell CJ; VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA., Gaziano JM; VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham Women's Hospital, Boston, MA, USA., Wilson PWF; Atlanta VA Health Care System, Decatur, GA, USA.; Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK., Hirschhorn JN; Boston Children's Hospital, EndocrinologyBoston, MA, 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Departments of Pediatrics and Genetics, Harvard Medical School, Boston, MA, USA., Kathiresan S; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK., Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Brown CD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Natarajan P; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Deloukas P; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Willer CJ; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA. cristen@umich.edu.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. cristen@umich.edu.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, 48109, USA. cristen@umich.edu., Assimes TL; VA Palo Alto Health Care Systems, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, Boston, MA, 02118, USA. gpeloso@bu.edu.

Publikováno v: Genome biology [Genome Biol] 2022 Dec 27; Vol. 23 (1), pp. 268. Date of Electronic Publication: 2022 Dec 27.

A saturated map of common genetic variants associated with human height.

Autor: Yengo L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. l.yengo@imb.uq.edu.au., Vedantam S; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Sidorenko J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Bartell E; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Sakaue S; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eliasen AU; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark., Jiang Y; 23andMe, Sunnyvale, CA, USA., Raghavan S; Department of Veterans Affairs, Eastern Colorado Healthcare System, Aurora, CO, USA.; Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Miao J; Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arias JD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Mukamel RE; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Spracklen CN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA., Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Chen SH; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Ferreira T; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Highland HH; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ji Y; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK., Karaderi T; Center for Health Data Science, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lüll K; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia., Malden DE; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Machado M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Moore A; Division of Biostatistics and Epidemiology, RTI International, Durham, NC, USA., Rüeger S; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Ahluwalia TS; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Department of Biology, The Bioinformatics Center, University of Copenhagen, Copenhagen, Denmark., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Allison MA; Department of Family Medicine, University of California, San Diego, La Jolla, CA, USA., Alvarez M; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Andersen MK; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ani A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Appadurai V; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bhaskar S; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India., Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Bonnycastle LL; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bradfield JP; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Quantinuum Research, Wayne, PA, USA., Bradford Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Burgdorf KS; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; NovoNordic Center for Protein Research, Copenhagen University, Copenhagen, Denmark., Cade BE; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Cai H; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Cai Q; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Catamo E; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, Medical College, National Taiwan University, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chesi A; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Choi SH; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chung RH; Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan., Cocca M; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Concas MP; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Couture C; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada., Cuellar-Partida G; 23andMe, Sunnyvale, CA, USA.; Diamantina Institute, The University of Queensland, Brisbane, Queensland, Australia., Danning R; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Degenhard F; Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Delitala A; Dipartimento di Scienze Mediche Chirurgiche e Sperimentali, Università degli Studi di Sassari, Sassari, Italy., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Deng X; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Devineni P; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Dietl A; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Dimitriou M; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece., Dimitrov L; Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore., Ekici AB; Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Engmann JE; Institute of Cardiovascular Science, Faculty of Population Health, University College London, London, UK., Fairhurst-Hunter Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Farmaki AE; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fernandez-Lopez JC; Computational Genomics Department, National Institute of Genomic Medicine, Mexico City, Mexico., Forer L; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Francescatto M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Fuchsberger C; Eurac Research, Institute for Biomedicine, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands., Gao Y; Jackson Heart Study, Department of Medicine, University of Mississippi, Jackson, MS, USA., Gao Z; Nanjing University of Chinese Medicine, Nanjing, China.; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany., Geller F; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Gordon SD; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Grove J; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; BiRC-Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Gustafsson S; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Haessler J; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hansen TF; Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Copenhagen, Denmark.; NovoNordic Center for Protein Research, Copenhagen University, Copenhagen, Denmark.; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Rigshospitalet, Copenhagen, Denmark., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Haworth SJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Dental School, University of Bristol, Bristol, UK., He J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Heard-Costa N; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Hindy G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden., Ho YA; Veterans Affairs Boston Healthcare System, Boston, MA, USA., Hofer E; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Holliday E; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Horn K; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany., Hornsby WE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Hottenga JJ; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Huang H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Huang J; School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.; Institute for Global Health and Development, Peking University, Beijing, China., Huerta-Chagoya A; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México Ciudad Universitaria, Mexico City, Mexico.; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico., Huffman JE; Veterans Affairs Boston Healthcare System, Boston, MA, USA., Hung YJ; Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan., Isono M; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Jansen IE; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Department of Child and Adolescent Psychiatry and Pediatric Psychology, Section Complex Trait Genetics, Amsterdam Neuroscience, Vrije Universiteit Medical Center, Amsterdam, The Netherlands., Johansson I; Department of Biobank Research, Umeå University, Umeå, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Jonas JB; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland.; Privatpraxis Prof Jonas und Dr Panda-Jonas, Heidelberg, Germany.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China., Jonsson A; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jørgensen T; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kalafati IP; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece., Kanai M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kårhus LL; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Kasturiratne A; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Katsuya T; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kember RL; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Kentistou KA; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.; Department of Clinical Research Design and Evaluation (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany., Knol MJ; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Kurbasic A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Lauzon M; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Le P; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Lea R; Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Lee JY; Oneomics, Soonchunhyang Mirai Medical Center, Bucheon-si, Republic of Korea., Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Li SA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.; Cancer Genomics Research Laboratory, Leidos Biomedical Research, Rockville, MD, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.; Department of Mathematics and Statistics, St Cloud State University, St Cloud, MN, USA., Liang J; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Lin H; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lin SY; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Liu X; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Lo KS; Montreal Heart Institute, Montreal, Quebec, Canada., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Lores-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lyssenko V; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.; Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Mamakou V; National and Kapodistrian University of Athens, Dromokaiteio Psychiatric Hospital, Athens, Greece., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Manichaikul A; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Mattheisen M; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; Department of Psychiatry and Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany., Mavarani L; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany., McDaid AF; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Melendez TL; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Mercader JM; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Milaneschi Y; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC and Vrije Universiteit, Amsterdam, The Netherlands., Miller JE; Biomedical and Translational Informatics Institute, Geisinger, Danville, PA, USA.; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Mishra PP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Mitchell RE; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Møllehave LT; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Morgan A; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy., Mucha S; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Nho CW; Korea Institute of Science and Technology, Gangneung Institute of Natural Products, Gangneung, Republic of Korea., Nielsen AA; Department of Clinical Biochemistry, Lillebaelt Hospital, Kolding, Denmark., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Nongmaithem SS; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Nutile T; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy., Pandit A; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Pärna K; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Petersen ERB; Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland, Aabenraa, Denmark., Petersen LV; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; The National Centre for Register-based Research, University of Aarhus, Aarhus, Denmark., Pitkänen N; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland., Polašek O; Medical School, University of Split, Split, Croatia.; Algebra University College, Zagreb, Croatia., Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Pyarajan S; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Rakugi H; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Ramirez J; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Aragon Institute of Engineering Research, University of Zaragoza, Zaragoza, Spain.; Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Raven D; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK., Riveros C; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, New South Wales, Australia., Rohde R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ruggiero D; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Italy., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Ryan KA; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Sabater-Lleal M; Unit of Genomics of Complex Diseases, Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Stockholm, Sweden., Saxena R; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany., Sendamarai A; Center for Data and Computational Sciences, VA Boston Healthcare System, Boston, MA, USA., Shen B; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Shi J; 23andMe, Sunnyvale, CA, USA., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Sidore C; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy., Sitlani CM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Slieker RC; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Epidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Smit RAJ; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Smith AV; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Icelandic Heart Association, Kópavogur, Iceland., Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Sanger Institute, Hinxton, UK., Steinthorsdottir V; deCODE Genetics/Amgen, Reykjavik, Iceland., Sun L; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Takeuchi F; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Tallapragada DSP; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Tayo BO; Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA., Tcheandjieu C; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Tesolin P; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Theusch E; Cardiology Division, Department of Pediatrics, University of California, San Francisco, Oakland, CA, USA., Thompson DJ; Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Thorleifsson G; deCODE Genetics/Amgen, Reykjavik, Iceland., Timmers PRHJ; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Turman C; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Vaccargiu S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Klinken JB; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Core Facility Metabolomics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Verma SS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Veturi Y; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Wang CA; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, New South Wales, Australia., Wang C; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Warren HR; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Bin Wei W; Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wickremasinghe AR; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Dermatology, Medical University of Vienna, Vienna, Austria., Wiggins KL; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Winsvold BS; Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.; Department of Neurology, Oslo University Hospital, Oslo, Norway., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK., Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Wuttke M; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.; Department of Medicine IV - Nephrology and Primary Care, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Xia R; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Yamamoto K; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young H; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Zeng L; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany., Zhang W; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Zhang X; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK., Zhao W; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Zoledziewska M; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Adams HHH; Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.; Latin American Brain Health (BrainLat), Universidad Adolfo Ibáñez, Santiago, Chile., Aguilar-Salinas CA; Unidad de Investigacion de Enfermedades Metabolicas and Direction of Nutrition, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait City, Kuwait., Arnett DK; Department of Epidemiology and Dean's Office, College of Public Health, University of Kentucky, Lexington, KY, USA., Asselbergs FW; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.; Health Data Research UK and Institute of Health Informatics, University College London, London, UK., Åsvold BO; KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Attia J; School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia., Banas B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Bandinelli S; Geriatric Unit, Azienda Toscana Centro, Florence, Italy., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Bergler T; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Bharadwaj D; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University (JNU), New Delhi, India., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Boerwinkle E; Human Genetics Center and Department of Epidemiology, University of Texas Health Science Center at Houston, Houston, TX, USA., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Boomsma DI; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Børglum AD; Department of Biomedicine (Human Genetics) and iSEQ Center, Aarhus University, Aarhus, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.; Center for Genomics and Personalized Medicine (CGPM), Aarhus University, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Borja JB; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Bowden DW; Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Brumpton B; KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Buring JE; Harvard Medical School, Boston, MA, USA.; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Caulfield MJ; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Chambers JC; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Chandak GR; Genomic Research on Complex diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Adjunct Faculty, JSS University Academy of Higher Education and Research (JSSAHER), JSS (Deemed to be) University, Mysuru, India., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, Institute of Cardiovascular Science, University College London, London, UK., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; MRC Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Christophersen IE; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway., Ciullo M; Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Italy., Cole JW; Department of Neurology, Division of Vascular Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.; Baltimore Veterans Affairs Medical Center, Department of Neurology, Baltimore, MD, USA., Collins FS; Molecular Genetics Section, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Cooper RS; Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL, USA., Cruz M; Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.; Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Cutler MJ; Intermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA., Damrauer SM; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Dantoft TM; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., de Borst GJ; Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., de Groot LCPGM; Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands., De Jager PL; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA., de Kleijn DPV; Department of Vascular Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Janaka de Silva H; Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Dedoussis GV; Department of Nutrition and Dietetics, School of Health and Education, Harokopio University of Athens, Athens, Greece., den Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Easton DF; Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Cambridge, UK., Elders PJM; Department of General Practice, Amsterdam Public Health Institute, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands., Eliassen AH; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Ellinor PT; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Elmståhl S; Department of Clinical Sciences in Malmö, Division of Geriatric Medicine, Lund University, Malmö, Sweden., Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research) partner site Hamburg/Lübeck/Kiel and University Heart Center Lübeck, Lübeck, Germany., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fatkin D; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.; Faculty of Medicine, UNSW Sydney, Kensington, New South Wales, Australia., Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Ferrucci L; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts University of Kiel, Kiel, Germany., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, Sweden.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Freedman BI; Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA., Gasparini P; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Girotto G; Institute for Maternal and Child Health - IRCCS, Burlo Garofolo, Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Goddard ME; Faculty of Veterinary and Agricultural Science, University of Melbourne, Parkville, Victoria, Australia.; Agriculture Victoria Research, Department of Jobs, Precincts and Regions, Bundoora, Victoria, Australia., Golightly YM; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gonzalez-Villalpando C; Centro de Investigacion en Salud Poblacional Instituto Nacional de Salud Publica and Centro de Estudios en Diabetes, Cuernavaca, Mexico., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grant SFA; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Departments of Pediatrics and Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Griffiths L; Genomics Research Centre, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Kelvin Grove, Queensland, Australia., Gudnason V; Icelandic Heart Association, Kópavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Haiman C; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hartman CA; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Hattersley AT; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Heckbert SR; Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore., Hengstenberg C; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Hewitt AW; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia.; Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, Perth, Western Australia, Australia., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Tokushima, Japan., Hoyng CB; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Huang PL; Harvard Medical School, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Heath and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai, China., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Hveem K; KG Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway., Hyppönen E; Australian Centre for Precision Health, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Iacono WG; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, School of Medicine, Ohio State University, Columbus, OH, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu University Hospital, OYS, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UK., Jin ZB; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Jöckel KH; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany., Joshi PK; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK., Jousilahti P; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kamatani Y; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Kang KD; Department of Ophthalmology, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, Republic of Korea., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Kato N; Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Kessler T; Department of Cardiology, German Heart Centre Munich, Technical University Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany., Khera AV; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kiemeney LALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, The Netherlands., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, Republic of Korea., Kim EK; Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.; Saevit Eye Hospital, Goyang, Republic of Korea., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Republic of Korea., Kirchhof P; Department of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.; German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.; Atrial Fibrillation NETwork, Münster, Germany., Kivimaki M; Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Koistinen HA; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kolovou GD; Department of Preventive Cardiology, Lipoprotein Apheresis Unit and Lipid Disorders Clinic, Metropolitan Hospital, Athens, Greece., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Kovacs P; Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Kraaijeveld A; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Krauss RM; Cardiology Division, Department of Pediatrics, University of California, San Francisco, Oakland, CA, USA., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Kutalik Z; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lange LA; Department of Medicine, University of Colorado at Denver, Aurora, CO, USA., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Le Marchand L; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA., Lee H; Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Republic of Korea., Lee NR; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Li L; Department of Epidemiology and Biostatistics, Peking University Health Science Center, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Lieb W; Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.; Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, China., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Linneberg A; Center for Clinical Research and Prevention, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Medical Faculty, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Medical Faculty, Leipzig, Germany., London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA., Lubitz SA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lye SJ; Alliance for Human Development, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada., Mackey DA; Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.; Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, Perth, Western Australia, Australia., Mägi R; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Marcus GM; Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA., Vidal PM; Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.; University of Lausanne, Lausanne, Switzerland., Martin NG; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB Academy, SYNLAB Holding Deutschland, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., McGarrah RW; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA.; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA., McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Medland SE; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Metspalu A; Institute of Genomics, Estonian Genome Centre, University of Tartu, Tartu, Estonia., Mitchell BD; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Mitchell P; Centre for Vision Research and Department of Ophthalmology, Westmead Millennium Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Mucci LA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Munroe PB; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Nazarian S; Electrophysiology Section, Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nelson AE; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Newton-Cheh C; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Nielsen CS; Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.; Department of Pain Management and Research, Oslo University Hospital, Oslo, Norway., Nöthen MM; Institute of Human Genetics, School of Medicine and University Hospital Bonn, Bonn, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Sahlgrenska University Hospital, Department of Drug Treatment, Gothenburg, Sweden., Oldehinkel AJ; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Orozco L; Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, CDMX, Mexico City, Mexico., Pahkala K; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Palmer CNA; Pat MacPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Pattaro C; Eurac Research, Institute for Biomedicine, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pennell CE; Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia.; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, New Lambton Heights, New South Wales, Australia., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC and Vrije Universiteit, Amsterdam, The Netherlands., Perusse L; Department of Kinesiology, Faculty of Medicine, Université Laval, Québec City, Quebec, Canada.; Centre Nutrition, Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods, Université Laval, Québec City, Quebec, Canada., Peters A; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; 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The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Stampfer MJ; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Epidemiology, Harvard T.H. 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Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Yajnik CS; Diabetes Unit, KEM Hospital and Research Centre, Pune, India., Yokota M; Kurume University School of Medicine, Kurume, Japan., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Sanger Institute, Hinxton, UK.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Zemel BS; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Center for Spatial and Functional Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; 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Department of Biomedical Science, Hallym University, Chuncheon, Republic of Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.; Genentech, South San Francisco, CA, USA., Ng MCY; Center for Precision Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA.; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., O'Donnell CJ; Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Veterans Affairs Boston Healthcare System, Boston, MA, USA., Rivadeneira F; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Thorsteinsdottir U; deCODE Genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Deloukas P; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Justice AE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Population Health Sciences, Geisinger, Danville, PA, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., North KE; 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Publikováno v: Nature [Nature] 2022 Oct; Vol. 610 (7933), pp. 704-712. Date of Electronic Publication: 2022 Oct 12.

The power of genetic diversity in genome-wide association studies of lipids.

Autor: Graham SE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Clarke SL; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Wu KH; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Zajac GJM; Department of Biostatistics and Center for Statistics Genetics, University of Michigan, Ann Arbor, MI, USA., Ramdas S; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Surakka I; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Ntalla I; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Vedantam S; Endocrinology, Boston Children's Hospital, Boston, MA, USA.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Winkler TW; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Locke AE; McDonnell Genome Institute and Department of Medicine, Washington University, St Louis, MO, USA., Marouli E; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hwang MY; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Han S; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Narita A; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Ekoru K; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Trivedi B; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Martin HC; Wellcome Sanger Institute, Hinxton, UK., Hunt KA; Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hui Q; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Klarin D; Malcolm Randall VA Medical Center, Gainesville, FL, USA.; Division of Vascular Surgery and Endovascular Therapy, University of Florida College of Medicine, Gainesville, FL, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhu X; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Statistics, The Pennsylvania State University, University Park, PA, USA.; Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA.; Department of Statistics, Stanford University, Stanford, CA, USA., Thorleifsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Helgadottir A; deCODE genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali-National University Hospital of Iceland, Reykjavik, Iceland., Akiyama M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Sakaue S; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Terao C; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kanai M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Zhou W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Brumpton BM; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Thoracic Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Rasheed H; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Ruotsalainen SE; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Havulinna AS; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Veturi Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Feng Q; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rosenthal EA; Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA., Lingren T; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pacheco JA; Center for Genetic Medicine, Northwestern University, Evanston, IL, USA., Pendergrass SA; Genentech, South San Francisco, CA, USA., Haessler J; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bradford Y; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Miller JE; Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK., Lin K; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Millwood IY; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hindy G; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Turman C; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Huang H; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Graff M; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Brown MR; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK., Yu K; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Schmidt EM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pandit A; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Gustafsson S; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Yin X; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zhao JH; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge Strangeways Research Laboratory, Cambridge, UK., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jang HM; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Yoon K; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Medina-Gomez C; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Pitsillides A; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Willemsen G; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Wood AR; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Ji Y; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Gao Z; Department of Clinical Acupuncture and Moxibustion, Nanjing University of Chinese Medicine, Nanjing, China.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Haworth S; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Bristol Dental School, University of Bristol, Bristol, UK., Mitchell RE; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Aadahl M; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Ramirez J; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Sabater-Lleal M; Group of Genomics of Complex Diseases, Research Institute of Hospital de la Santa Creu i Sant Pau (IIB Sant Pau), Barcelona, Spain.; Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden., Noordam R; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Sidore C; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari,, Italy., Fiorillo E; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Lanusei, Italy., McDaid AF; University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Marques-Vidal P; Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Wielscher M; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, UK., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Thuesen BH; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Munz M; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck, Germany.; Charité-University Medicine Berlin, Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Periodontology and Synoptic Dentistry, Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Berlin, Germany., Zeng L; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner site Munich Heart Alliance, Munich, Germany., Huang J; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang B; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Poveda A; Lund University Diabetes Centre, Malmo, Sweden., Kurbasic A; Lund University Diabetes Centre, Malmo, Sweden., Lamina C; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Innsbruck, Austria., Forer L; Department of Genetics and Pharmacology, Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; German Chronic Kidney Disease Study, Innsbruck, Austria., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Galesloot TE; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Bradfield JP; Quantinuum Research, Wayne, PA, USA., Daw EW; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Zmuda JM; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA., Mitchell JS; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Fuchsberger C; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Christensen H; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Wojczynski MK; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Christofidou P; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Benjamins JW; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Engmann J; Institute of Cardiovascular Sciences, University College London, London, UK.; Department of Epidemiology and Public Health, University College London, London, UK., Kember RL; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA., Slieker RC; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Lo KS; Montreal Heart Institute, Montreal, Quebec, Canada., Zilhao NR; Icelandic Heart Association, Reykjavik, Iceland., Le P; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab MVZ Humangenetik Mannheim, Mannheim, Germany., Delgado GE; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Huo S; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Ikeda DD; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Iha H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Institute for Advanced Research, Wenzhou Medical University, Wenzhou, China., Liu J; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Marten J; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Schmidt B; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., Arendt M; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany.; Department of Computer Science, University of Applied Sciences and Arts Dortmund, Dortmund, Germany., Smyth LJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Cañadas-Garre M; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Wong A; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Hutri-Kähönen N; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Xia R; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Huerta-Chagoya A; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de Mexico, Mexico, Mexico., Fernandez-Lopez JC; Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica, Ciudad de Mexico, Mexico, Mexico., Lyssenko V; Center for Diabetes Research, University of Bergen, Bergen, Norway.; Lund University Diabetes Center, Lund University, Malmo, Sweden., Ahmed M; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India., Jackson AU; Department of Biostatistics and Center for Statistics Genetics, University of Michigan, Ann Arbor, MI, USA., Yousri NA; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Computer and Systems Engineering, Alexandria University, Alexandria, Egypt., Irvin MR; Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Oldmeadow C; Hunter Medical Research Institute, Newcastle, New South Wales, Australia., Kim HN; Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea., Ryu S; Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea., Timmers PRHJ; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Arbeeva L; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA., Dorajoo R; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado, Denver, Aurora, CO, USA., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Prasad G; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India., Lorés-Motta L; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Pauper M; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Long J; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Li X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Theusch E; Department of Pediatrics, University of California, San Francisco, Oakland, CA,, USA., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts-Amherst, Amherst, MA,, USA., Loukola A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Warner SC; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wei WB; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Nutile T; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy., Ruggiero D; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Sung YJ; Department of Psychiatry, Washington University, St Louis, MO, USA., Hung YJ; Division of Endocrinology and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan., Chen S; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Liu F; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Gorski M; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Brumat M; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Meidtner K; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Smith JA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Hebbar P; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece.; Department of Population Science and Experimental Medicine, University College London, London, UK., Hofer E; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Lin M; Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA., Xue C; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Zhang J; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Concas MP; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., Vaccargiu S; Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy., van der Most PJ; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Pitkänen N; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Cade BE; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Lee J; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., van der Laan SW; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Chitrala KN; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, NIA, Baltimore, MD, USA., Weiss S; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Zimmermann ME; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Lee JY; Oneomics, Bucheon, Korea., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Freitag-Wolf S; Institute of Medical Informatics and Statistics, Kiel University, Kiel, Germany., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Trust Sanger Institute, Hinxton, UK., Rayner NW; Wellcome Sanger Institute, Hinxton, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia., Lin SY; Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Wang JS; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan., Couture C; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Cuellar-Partida G; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Ronne, Denmark., Hildalgo B; School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Giannakopoulou O; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Cai Q; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Obura MO; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., van Setten J; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Li X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Schwander K; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Terzikhan N; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Shin JH; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Jackson RD; Division of Endocrinology, Ohio State University, Columbus, OH, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Martin LW; School of Medicine and Health Sciences, George Washington University, Washington, DC, USA., Chen Z; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Li L; Department of Epidemiology, School of Public Health, Peking University Health Science Center, Beijing, China., Highland HM; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Young KL; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Thiery J; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, University Hospital Leipzig, Leipzig, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD, USA., Li H; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Wild SH; Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Jäger S; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Al-Mulla F; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Niinikoski H; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.; Department of Physiology, University of Turku, Turku, Finland., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kolcic I; Faculty of Medicine, University of Split, Split, Croatia., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Giardoglou T; Department of Nutrition-Dietetics, Harokopio University, Eleftheriou Venizelou, Athens, Greece., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Bhatti KF; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., de Kleijn D; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., de Borst GJ; Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kim EK; Corneal Dystrophy Research Institute, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea., Adams HHH; Department of Radiology and Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Clinical Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Zhu X; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA., Asselbergs FW; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Kraaijeveld AO; Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Beulens JWJ; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands., Shu XO; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Rallidis LS; Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mitchell P; Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney, Sydney, New South Wales, Australia., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Pérusse L; Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.; Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada., Bouchard C; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia., Mori TA; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia., Lieb W; Institute of Epidemiology, Kiel University, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellström D; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, Korea., Lee H; Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore., Rhee SY; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea., Woo JT; Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea., Heid IM; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Stark KJ; Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Homuth G; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald and University Medicine Greifswald, Greifswald, Germany., Evans MK; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, MD, USA., Zonderman AB; Laboratory of Epidemiology and Population Science, National Institute on Aging Intramural Research Program, NIH Biomedical Research Center, Baltimore, MD, USA., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Pasterkamp G; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Hoefer IE; Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Redline S; Sleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Pahkala K; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Snieder H; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Biino G; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy., Schmidt R; Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Graz, Austria., Schmidt H; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria., Chen YE; Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA., Bandinelli S; Local Health Unit Toscana Centro, Firenze, Italy., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Thanaraj TA; Department of Genetics and Bioinformatics, Dasman Diabetes Institute, Kuwait, Kuwait., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany., Girotto G; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.; Institute for Maternal and Child Health IRCCS 'Burlo Garofolo', Trieste, Italy., Jung B; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany., Böger CA; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.; Department of Nephrology, Diabetology, Rheumatology, Traunstein Hospital, Traunstein, Germany.; KfH Kidney Center Traunstein, Traunstein, Germany., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., De Jager PL; Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Lu X; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Mamakou V; Medical School, National and Kapodistrian University Athens, Athens, Greece.; Dromokaiteio Psychiatric Hospital, Athens, Greece., Brown M; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, John Vane Science Centre, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Ciullo M; Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Kaprio J; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Pajukanta P; Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, Los Angeles, CA, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Bechayda SA; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.; Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Krauss RM; Departments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Zheng W; Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., den Hollander AI; Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology Campus, New Delhi, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Heng CK; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore., Nelson AE; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Golightly YM; Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, USA.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Injury Prevention Research Center, University of North Carolina, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina, Chapel Hill, NC, USA., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Penninx B; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Kim HL; Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, Korea., Attia J; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia., Scott RJ; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia., Rao DC; Division of Biostatistics, Washington University School of Medicine, St Louis, MO, USA., Arnett DK; University of Kentucky, College of Public Health, Lexington, KY, USA., Hunt SC; Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.; Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA., Walker M; Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Newcastle upon Tyne, UK., Koistinen HA; Department of Population Health, Finnish Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Chandak GR; Genomic Research on Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India., Yajnik CS; Diabetology Research Centre, KEM Hospital and Research Centre, Pune, India., Mercader JM; Harvard Medical School, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Tusié-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México, Mexico, Mexico.; Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Bimédicas UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Aguilar-Salinas CA; Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Dirección de Nutrición and Unidad de Estudios de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Villalpando CG; Instituto Nacional de Salud Publica y Centro de Estudios en Diabetes, Cuernavaca, Mexico., Orozco L; Instituto Nacional de Medicina Genómica, Mexico, Mexico., Fornage M; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Chaturvedi N; MRC Unit for Lifelong Health and Ageing at UCL, London, UK., Yokota M; Kurume University School of Medicine, Kurume, Japan., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Reilly DF; Genetics, Merck Sharp & Dohme, Kenilworth, NJ, USA., McKnight AJ; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Kee F; Centre for Public Health, Queen's University of Belfast, Belfast, UK., Jöckel KH; Institute for Medical Informatics, Biometrie and Epidemiology, University of Duisburg-Essen, Essen, Germany., McCarthy MI; Genentech, South San Francisco, CA, USA.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Palmer CNA; Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School, Dundee, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Simonsick E; Intramural Research Program, National Institute on Aging, Baltimore, MD, USA., van Duijn CM; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Lu F; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Hishigaki H; Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Tokushima, Japan., Lin X; Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, Mexico., Gudnason V; Icelandic Heart Association, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tardif JC; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medecine, Université de Montréal, Quebec, Quebec, Canada., Lettre G; Montreal Heart Institute, Montreal, Quebec, Canada.; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada., 't Hart LM; Amsterdam UMC, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Elders PJM; Amsterdam UMC, Department of General Practice and Elderly Care, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Damrauer SM; Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael Crescenz VA Medical Center, Philadelphia, PA, USA., Kumari M; Institute of Social and Economic Research, University of Essex, Essex, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., van der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Province MA; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, MO, USA., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanent Washington Health Research Institute, Seattle, WA, USA., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Christensen K; Danish Aging Research Center, University of Southern Denmark, Odense, Denmark., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Widén E; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland., Hakonarson H; Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA., Grant SFA; Department of Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Kiemeney LALM; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., de Graaf J; Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany., Kronenberg F; German Chronic Kidney Disease Study, Innsbruck, Austria.; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Gu D; Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; School of Medicine, Southern University of Science and Technology, Shenzhen, China., Erdmann J; Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck, Lübeck, Germany., Schunkert H; Deutsches Herzzentrum München, Klinik für Herz- und Kreislauferkrankungen, Technische Universität München, Munich, Germany.; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) e.V., Partner site Munich Heart Alliance, Munich, Germany., Franks PW; Lund University Diabetes Centre, Malmo, Sweden., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Khera AV; Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program of Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Männikkö M; Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter of Oulu, University of Oulu, Oulu, Finland., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Center for Primary Care and Public Health, Lausanne, Switzerland., Cucca F; Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR), Cagliari, Italy.; University of Sassari, Sassari, Italy., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands., van Dijk KW; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK., Strachan DP; Population Health Research Institute, St George's University of London, London, UK., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sever P; National Heart and Lung Institute, Imperial College London, London, UK., Poulter N; School of Public Health, Imperial College London, London, UK., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center, Torrance, CA, USA., Dantoft TM; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Karpe F; OCDEM, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Neville MJ; OCDEM, University of Oxford, Churchill Hospital, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; DZHK (German Centre for Cardiovascular Research), Munich Heart Alliance Partner Site, Munich, Germany., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Magnusson PKE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Boomsma DI; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, VU Medical Center Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, VU Medical Center Amsterdam, Amsterdam, the Netherlands., de Geus EJC; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Research Institute, VU Medical Center Amsterdam, Amsterdam, The Netherlands., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD, USA., van Meurs JBJ; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China., Kim YJ; Department of Precision Medicine, Division of Genome Science, National Institute of Health, Cheongju-si, South Korea., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Wellcome Trust Sanger Institute, Hinxton, UK.; TUM School of Medicine, Technical University of Munich (TUM) and Klinikum Rechts der Isar, Munich, Germany., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; 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Publikováno v: Nature [Nature] 2021 Dec; Vol. 600 (7890), pp. 675-679. Date of Electronic Publication: 2021 Dec 09.