Zobrazeno 1 - 10 of 160 pro vyhledávání: '"JAROMIR PASTOREK"'
1
Akademický článek
Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX
Autor: Miriam Zatovicova, Ivana Kajanova, Monika Barathova, Martina Takacova, Martina Labudova, Lucia Csaderova, Lenka Jelenska, Eliska Svastova, Silvia Pastorekova, Adrian L. Harris, Jaromir Pastorek
Publikováno v: Cancer & Metabolism, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background Hypoxia in the tumor microenvironment (TME) is often the main factor in the cancer progression. Moreover, low levels of oxygen in tumor tissue may signal that the first- or second-line therapy will not be successful. This knowledg
Externí odkaz: https://doaj.org/article/e6274b37750142d7bf1bd22aaf2132f5
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2
Akademický článek
Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins.
Autor: Heini Kallio, Martti Tolvanen, Janne Jänis, Pei-wen Pan, Eeva Laurila, Anne Kallioniemi, Sami Kilpinen, Vilppu J Tuominen, Jorma Isola, Jarkko Valjakka, Silvia Pastorekova, Jaromir Pastorek, Seppo Parkkila
Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27152 (2011)
Our previous microarray study showed that the non-specific cytotoxic cell receptor protein 1 (Nccrp1) transcript is significantly upregulated in the gastric mucosa of carbonic anhydrase IX (CA IX)-deficient (Car9(-/-)) mice. In this paper, we aimed t
Externí odkaz: https://doaj.org/article/bae20915bfed4d848993aed335d49468
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3
Propranolol, Promising Chemosensitizer and Candidate for the Combined Therapy through Disruption of Tumor Microenvironment Homeostasis by Decreasing the Level of Carbonic Anhydrase IX
Autor: Barathova, Barbora Puzderova, Petra Belvoncikova, Katarina Grossmannova, Lucia Csaderova, Martina Labudova, Silvia Fecikova, Jaromir Pastorek, Monika
Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11094
Resistance to chemotherapy represents a persisting medical problem, ranking among main causes of chemotherapy failure and cancer mortality. There is a possibility to utilize and repurpose already existing therapeutics which were not primarily intende
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::7325846ed799d97111e355e80c07ebbe
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9
Data from Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors
Autor: Jaromir Pastorek, Silvia Pastorekova, Claudiu T. Supuran, Juraj Kopacek, Lucia Csaderova, Miriam Zatovicova, Anna Ohradanova-Repic, Alzbeta Hulikova, Eliska Svastova, Franck Dequiedt, Peter Ditte
In the hypoxic regions of a tumor, carbonic anhydrase IX (CA IX) is an important transmembrane component of the pH regulatory machinery that participates in bicarbonate transport. Because tumor pH has implications for growth, invasion, and therapy, d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3b9127e9a74d57452c6c9f100e30791
https://doi.org/10.1158/0008-5472.c.6502812.v1
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