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Animal model to measure visceral pain of a balloon catheter and an implantable sensor module having transcutaneous telemetring ability. The implantable sensor module is set up to receive both visceromotor and pseudoaffective responses of the test ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::301d8522bcf037aac97d42c0ebb3a0fd
https://register.epo.org/application?number=EP0311329
https://register.epo.org/application?number=EP0311329
Autor:
JANSSEN PHARMACEUTICA NV, JANSSENS FRANS EDUARD, SOMMEN FRANCOIS MARIA, DE BOECK BENOIT CHRISTIAN ALBE, LEENAERTS JOSEPH ELISABETH, VAN ROOSBROECK YVES EMIEL MARI, DIELS GASTON STANISLAS MARCELL
The invention concerns substituted 1,4-di-piperidin-4-yl-piperazine derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::5fc45ba77916728580354d3c823f7e99
https://register.epo.org/application?number=EP0350697
https://register.epo.org/application?number=EP0350697
Autor:
JANSSEN PHARMACEUTICA NV, MEDAER BART PETRUS ANNA MARIA, STOKBROEKX SIGRID CARL MARIA, RUYSSCHAERT YVES GEORGES, WILLEMS JOANNES JOSEPHUS MARIA, WEERTS JOHAN ERWIN EDMOND
The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I) the N-oxide forms and the stereochemically isomeric forms thereof, wherein R and R each independently are h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::db935616baab4bb8575b826b546c87fe
https://register.epo.org/application?number=EP0211136
https://register.epo.org/application?number=EP0211136
There is disclosed a mammalian receptor protein designated GFR alpha -4 and the nucleic acid sequence encoding therefor. Also provided is an expression vector comprising the nucleic acid sequence and host cells transformed or transfected with the vec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::2406b2ba47326026dae737b203fd0b42
https://register.epo.org/application?number=EP0004918
https://register.epo.org/application?number=EP0004918
IMIDAZO(1,2-A)(PYRROLO, THIENO OR FURANO)(3,2-D)AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE
Autor:
JANSSEN PHARMACEUTICA NV
The present invention is concerned with novel imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::8f19297aa10cce0f4430c9532ae8c190
https://register.epo.org/application?number=EP9201331
https://register.epo.org/application?number=EP9201331
The present invention concerns novel formulations comprising an antifungal agent having a low solubility in aqueous media, a process for preparing said formulations and pharmaceutical dosage forms comprising said novel formulations for nasal administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::daccdf08474ed90410594dcf1f5ba75a
https://register.epo.org/application?number=EP0005679
https://register.epo.org/application?number=EP0005679
This invention comprises the novel compounds of formula (I), wherein s, t, Y, Y, R, R, R, R, R, R and R have defined meanings, having farnesyl transferase inhibiting activity; their preparation, compositions containing them and their use as a medicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::9059cc3d8d70a061101eeaadfe978c41
https://register.epo.org/application?number=EP0115232
https://register.epo.org/application?number=EP0115232
Autor:
JANSSEN PHARMACEUTICA NV, MABIRE DOMINIQUE JEAN-PIERRE, GUILLEMONT JEROME EMILE GEORGE, VAN DUN JACOBUS ALPHONSUS JOSE, SOMERS MARIA VICTORINA FRANCIS, WOUTERS WALTER BOUDEWIJN LEOPO
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R, R, R, R, and X have defined meanings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=epopatstat__::2566e1d9eb1743f816b485cd0dbf35df
https://register.epo.org/application?number=EP2004013164
https://register.epo.org/application?number=EP2004013164
