Zobrazeno 1 - 10
of 18
pro vyhledávání: '"JANET N. RYAN"'
Autor:
Janet N. Ryan
Publikováno v:
Physics Today. 38:15-104
Autor:
J. F. Woessner, Janet N. Ryan
Publikováno v:
Journal of Endocrinology. 85:387-391
Treatment of parturient rats with 100 μg oestradiol/day caused a significant retardation of uterine involution and collagen breakdown. The post-partum uterus had a peroxidase activity of 180 μmol H2O2 reduced/min per uterus. Treatment with oestradi
Publikováno v:
Experimental and Molecular Pathology. 19:186-196
In rats treated for 20 or 34 days with CCl4 (0.2 ml/100 g, ip, twice weekly) a significant increase in the content of malonaldehyde product in microsomal and mitochondrial fractions of the liver occurred. The raise in this indirect index of lipid per
Autor:
Janet N. Ryan, Milos Chvapil
Publikováno v:
Biochemical and Biophysical Research Communications. 44:1292-1299
Summary In rats treated with varying doses of 1,10-phenanthroline the activity of aniline hydroxylase, morphine demethylase and the amount of cytochrome P 450 , aniline binding to the cytochrome and protein in liver microsomes were studied. A close c
Publikováno v:
Biochemical Pharmacology. 21:1097-1105
Diethyldithiocarbamate (DDC), penicillamine and sodium ethyldiaminetetraacetate (Na-EDTA) in 1 mM concentrations significantly stabilized the membrane of isolated liver lysosomes, as shown by a decreased release of β-glucuronidase upon incubation at
Autor:
Janet N. Ryan, J. Frederick Woessner
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 309:397-405
Collagenase activity can be detected in the 6000 × g pellets of homogenates of the involuting uterus of the rat; it digests the collagen present in the homogenates. This enzyme appears to be identical to the collagenase obtained from cultures of ute
Autor:
J. Frederick Woessner, Janet N. Ryan
Publikováno v:
The Biochemical journal. 127(4)
1. The earlier observation (Woessner, 1969) of oestradiol inhibition of collagen breakdown is confirmed and extended. Administration of 100μg of oestradiol-17β/day to parturient rats strongly inhibits the loss of collagen from the involuting uterus
Publikováno v:
Toxicology and applied pharmacology. 26(3)
The acute and chronic effects of 3,4,-dehydroproline (DHP) were investigated in mice. Given as a single dose ip, DHP is 13 times more toxic than 1-proline, the LD50 being 0.62 ± 0.05 g/kg. Ultrastructural changes observed in liver hepatocytes and gr
Autor:
Milos Chvapil, Janet N. Ryan
Publikováno v:
Agents and actions. 3(1)
The concentration and the specific activity of free proline are significantly increased in the livers of rats injured by acute and chronic treatment with the necrogenic agent, dimethylnitrosamine. 4 hours after the injection of ethionine at the dose
Autor:
J. Frederick Woessner, Janet N. Ryan
Publikováno v:
Biochemical and biophysical research communications. 44(1)
Summary Homogenates of involuting rat uterus contain an enzyme capable of digesting native collagen fibers at pH 7.5 and 37°. Collagenase activity and the uterine collagen are both found in the pellet when the homogenates are centrifuged at 6,000 g