Zobrazeno 1 - 10
of 1 182
pro vyhledávání: '"JAN-ÅKE GUSTAFSSON"'
Autor:
Julia M Scheffler, Karin L Gustafsson, Aidan Barrett, Carmen Corciulo, Christina Drevinge, Alicia M Del Carpio Pons, Piotr Humeniuk, Cecilia Engdahl, Jan‐Åke Gustafsson, Claes Ohlsson, Hans Carlsten, Marie K. Lagerquist, Ulrika Islander
Publikováno v:
JBMR Plus, Vol 6, Iss 8, Pp n/a-n/a (2022)
ABSTRACT Estrogen has pronounced effects on the immune system, which also influences bone homeostasis. In recent years, stromal cells in lymphoid organs have gained increasing attention as they not only support the regulation of immune responses but
Externí odkaz:
https://doaj.org/article/5535c5959b2c44f586cb4821311bfc39
Autor:
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjällström, Mohamed M. Shamekh, Jan-Åke Gustafsson, Anders F. Johansson, Ivan Nalvarte
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Sex hormones are known to interact with the immune system on multiple levels but information on the types of sex hormone receptors (SHR) and their expression levels in immune cells is scarce. Estrogen, testosterone and progesterone are all considered
Externí odkaz:
https://doaj.org/article/d49bd1cf7dd04a55a62b88fdcaabdd03
Autor:
Stefan Hauser, Marion Poenisch, Yvonne Schelling, Philip Höflinger, Stefanie Schuster, Axel Teegler, Rabea Betten, Jan-Åke Gustafsson, Jeannette Hübener-Schmid, Thomas Schlake, Frédéric Chevessier-Tünnesen, Nigel Horscroft, Ingemar Björkhem, Ludger Schöls
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 359-370 (2019)
Hereditary spastic paraplegia type 5 is a neurodegenerative disease caused by loss-of-function mutations in the CYP7B1 gene encoding the oxysterol 7-α-hydroxylase involved in bile acid synthesis in the liver. Lack of CYP7B1 leads to an accumulation
Externí odkaz:
https://doaj.org/article/4aeaa97d4bae48d099f191ccf0272017
Autor:
Marcela González-Granillo, Luisa A. Helguero, Eliana Alves, Amena Archer, Christina Savva, Matteo Pedrelli, Osman Ahmed, Xidan Li, Maria Rosário Domingues, Paolo Parini, Jan-Åke Gustafsson, Marion Korach-André
Publikováno v:
Biology of Sex Differences, Vol 10, Iss 1, Pp 1-17 (2019)
Abstract The response to overfeeding is sex dependent, and metabolic syndrome is more likely associated to obesity in men or postmenopausal women than in young fertile women. We hypothesized that obesity-induced metabolic syndrome is sex dependent du
Externí odkaz:
https://doaj.org/article/5766bece7b7e48c0b13564399c068757
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2165 (2022)
In this review, we discuss the role of liver X receptors (LXRs) in glial cells (microglia, oligodendrocytes and astrocytes) in the central nervous system (CNS). LXRs are oxysterol-activated nuclear receptors that, in adults, regulate genes involved i
Externí odkaz:
https://doaj.org/article/64e63d034d174950b5340830d48d0a70
Autor:
Shuang Huang, Nianxin Zhou, Linjie Zhao, Ryan C. Gimple, Young Ha Ahn, Peidong Zhang, Wei Wang, Bin Shao, Jingyun Yang, Qian Zhang, Sai Zhao, Xuehan Jiang, Zhiwei Chen, Yangfan Zeng, Hongbo Hu, Jan-Åke Gustafsson, Shengtao Zhou
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101458- (2020)
Summary: The emerging immune checkpoint blockade (ICB) therapy has ushered the cancer therapeutics field into an era of immunotherapy. Although ICB treatment provides remarkable clinical responses in a subset of patients with cancer, this regimen fai
Externí odkaz:
https://doaj.org/article/0290e7000b7f4a0ca89fde9c281e908f
Autor:
Surendra Chaurasiya, Scott Widmann, Cindy Botero, Chin-Yo Lin, Jan-Åke Gustafsson, Anders M Strom
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0226057 (2020)
Estrogen receptor β (ERβ) was first identified in the rodent prostate and is abundantly expressed in human and rodent prostate epithelium, stroma, immune cells and endothelium of the blood vessels. In the prostates of mice with inactivated ERβ, mu
Externí odkaz:
https://doaj.org/article/e2520a8e13524b76a09c7285bc8b6085
Autor:
Igor Bado, Fotis Nikolos, Gayani Rajapaksa, Wanfu Wu, Jessica Castaneda, Savitri Krishnamurthy, Paul Webb, Jan-Åke Gustafsson, Christoforos Thomas
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive
Externí odkaz:
https://doaj.org/article/4e0214d7458b442da0fadf13b89dcd62
Autor:
Jonas Abdel-Khalik, Eylan Yutuc, Peter J. Crick, Jan-Åke Gustafsson, Margaret Warner, Gustavo Roman, Kevin Talbot, Elizabeth Gray, William J. Griffiths, Martin R. Turner, Yuqin Wang
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 267-278 (2017)
As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels
Externí odkaz:
https://doaj.org/article/9d8e6d3705504fb48c95baea8195e5c8
Autor:
Marko Matic, Galyna Bryzgalova, Hui Gao, Per Antonson, Patricia Humire, Yoko Omoto, Neil Portwood, Camilla Pramfalk, Suad Efendic, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217526 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0057458.].
Externí odkaz:
https://doaj.org/article/78b26e0457114b85a3e8efa161028abe