Zobrazeno 1 - 10
of 115
pro vyhledávání: '"JAN BOREN"'
Autor:
Anwar Ali, Björn Redfors, Jessica Alkhoury, Jonatan Oras, Marcus Henricsson, Jan Boren, Elias Björnson, Aaron Espinosa, Malin Levin, Li‐Ming Gan, Elmir Omerovic
Publikováno v:
ESC Heart Failure, Vol 8, Iss 5, Pp 4130-4138 (2021)
Abstract Aims Takotsubo syndrome (TTS) is an acute potentially reversible cardiac syndrome characterized by variable regional myocardial akinesia that cannot be attributed to a culprit coronary artery occlusion. TTS is an important differential diagn
Externí odkaz:
https://doaj.org/article/a0476fe931184582a69f393cf4554398
Autor:
Cheng Zhang, Mengnan Shi, Woonghee Kim, Muhammad Arif, Martina Klevstig, Xiangyu Li, Hong Yang, Cemil Bayram, Ismail Bolat, Özlem Özdemir Tozlu, Ahmet Hacımuftuoglu, Serkan Yıldırım, Jihad Sebhaoui, Shazia Iqbal, Yongjun Wei, Xiaojing Shi, Jens Nielsen, Hasan Turkez, Mathias Uhlen, Jan Boren, Adil Mardinoglu
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104214- (2022)
Summary: Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver pathologies. However, no medical treatment has been approved for the treatment of NAFLD. In our previous study, we found that PKLR could be a potentia
Externí odkaz:
https://doaj.org/article/36818a6a57cf492cbc5540d8d174de87
Autor:
Xiangyu Li, Koeun Shong, Woonghee Kim, Meng Yuan, Hong Yang, Yusuke Sato, Haruki Kume, Seishi Ogawa, Hasan Turkez, Saeed Shoaie, Jan Boren, Jens Nielsen, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103963- (2022)
Summary: Background: The response rates of the clinical chemotherapies are still low in clear cell renal cell carcinoma (ccRCC). Computational drug repositioning is a promising strategy to discover new uses for existing drugs to treat patients who ca
Externí odkaz:
https://doaj.org/article/cc6732e4e3104a459997c3b0c8ddfa70
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Externí odkaz:
https://doaj.org/article/faebca1554664e4a8b901161dbd979fd
Autor:
Xiangyu Li, Woonghee Kim, Kajetan Juszczak, Muhammad Arif, Yusuke Sato, Haruki Kume, Seishi Ogawa, Hasan Turkez, Jan Boren, Jens Nielsen, Mathias Uhlen, Cheng Zhang, Adil Mardinoglu
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102722- (2021)
Summary: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment. Here, we applied a syst
Externí odkaz:
https://doaj.org/article/52a93b00478d4a87a1b9119115bb9801
Publikováno v:
EBioMedicine, Vol 49, Iss , Pp 364-373 (2019)
The advancement in high-throughput sequencing technologies and systems biology approaches have revolutionized our understanding of biological systems and opened a new path to investigate unacknowledged biological phenomena. In parallel, the field of
Externí odkaz:
https://doaj.org/article/617acadb0bc14ea894b3420f8af1adc6
Autor:
Rui Benfeitas, Gholamreza Bidkhori, Bani Mukhopadhyay, Martina Klevstig, Muhammad Arif, Cheng Zhang, Sunjae Lee, Resat Cinar, Jens Nielsen, Mathias Uhlen, Jan Boren, George Kunos, Adil Mardinoglu
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 471-487 (2019)
Background: Redox metabolism is often considered a potential target for cancer treatment, but a systematic examination of redox responses in hepatocellular carcinoma (HCC) is missing. Methods: Here, we employed systems biology and biological network
Externí odkaz:
https://doaj.org/article/4406d60ca65448679bcdaa61603a93a7
Autor:
Muhammad Arif, Martina Klevstig, Rui Benfeitas, Stephen Doran, Hasan Turkez, Mathias Uhlén, Maryam Clausen, Johannes Wikström, Damla Etal, Cheng Zhang, Malin Levin, Adil Mardinoglu, Jan Boren
Publikováno v:
eLife, Vol 10 (2021)
Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in
Externí odkaz:
https://doaj.org/article/3773ce265234459eb41aa49c78f1ab73
Autor:
Dorines Rosario, Jan Boren, Mathias Uhlen, Gordon Proctor, Dag Aarsland, Adil Mardinoglu, Saeed Shoaie
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Neurodegenerative diseases (NDDs) comprise a broad range of progressive neurological disorders with multifactorial etiology contributing to disease pathophysiology. Evidence of the microbiome involvement in the gut-brain axis urges the interest in un
Externí odkaz:
https://doaj.org/article/b95de6fe83be4acd83149ab1a6a33308
Autor:
Ozlem Altay, Elyas Mohammadi, Simon Lam, Hasan Turkez, Jan Boren, Jens Nielsen, Mathias Uhlen, Adil Mardinoglu
Publikováno v:
iScience, Vol 23, Iss 7, Pp 101303- (2020)
The rapid and global spread of a new human coronavirus (SARS-CoV-2) has produced an immediate urgency to discover promising targets for the treatment of COVID-19. Drug repositioning is an attractive approach that can facilitate the drug discovery pro
Externí odkaz:
https://doaj.org/article/35343d1548aa4bf1b16857380aeb4f8d