Zobrazeno 1 - 10
of 39
pro vyhledávání: '"JAMES V. McARDLE"'
Autor:
Daren S. Levin, Bernhard Noll, B.P. (Bob) Sharma, Rao V. B. Kambhampati, René Thürmer, Ramesh Raghavachari, Fran Wincott, Daniel C. Capaldi, Ken Draper, Doug Brooks, James V. McArdle, Judy Carmody, Ipsita Roymoulik, Kathy Ackley, Matthias Kretschmer
Publikováno v:
Drug Information Journal. 46:611-626
This article, which is the first in a planned series intended to address chemistry, manufacturing, and control (CMC) aspects of therapeutic oligonucleotides, examines the topic of specifications for active pharmaceutical ingredients (APIs). The autho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c60ef9da19bf975fa73594a77cbe4f4
https://doi.org/10.1177/0092861512445311
https://doi.org/10.1177/0092861512445311
Publikováno v:
Chemistry & Biodiversity. 7:656-665
Thermodynamic parameters for the reduction of ferrioxamine E as calculated from redox potentials determined at four different temperatures were found to be DeltaH( not equal)=7.1+/-3.4 kJ mol(-1) and DeltaS( not equal)=-146 J mol(-1) K(-1). The negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce7e24160ec7220214c86ae9d850630
https://doi.org/10.1002/cbdv.200900031
https://doi.org/10.1002/cbdv.200900031
Autor:
Vasulinga T. Ravikumar, Nhuy Luu, James V. McArdle, Isaiah Cedillo, Kym Bradley, Kent Van Sooy, Christine Kurata, Daniel C. Capaldi, Hans Gaus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:607-614
Phosphorothioate oligonucleotides manufactured by standard phosphoramidite techniques using 2'-deoxyadenosine- or 2'-O-(2-methoxyethyl)-5-methylcytosine-loaded solid supports contain branched impurities consisting of two chains linked through the exo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35314c892fb45f6c56f3f79c4ff2d129
https://doi.org/10.1016/j.bmcl.2005.10.051
https://doi.org/10.1016/j.bmcl.2005.10.051
Autor:
Phil Olsen, Dennis Gorman, Achim H. Krotz, Hans Gaus, Anthony N. Scozzari, Claus Rentel, James V. McArdle
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 23:767-775
The impuritiy profiles of acetonitrile solutions of the four standard O-cyanoethyl-N,N-diisopropyl-phosphoramidites of 5'-O-dimethoxytrityl (DMT) protected deoxyribonucleosides (dG(ib), dA(bz), dC(bz), T) were analyzed by HPLC-MS. The solution stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bfc73c731a8a91b0cd0482107ba9f0
https://doi.org/10.1081/ncn-120039215
https://doi.org/10.1081/ncn-120039215
Autor:
Hans Gaus, Stella D. Decottignies, Max N. Moore, Vasulinga T. Ravikumar, Brett Turney, Achim H. Krotz, James V. McArdle, Anthony N. Scozzari, Daniel C. Capaldi, Recaldo L. Carty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4683-4690
Incomplete sulfurization during solid-phase synthesis of phosphorothioate oligonucleotides using phosphoramidite chemistry was identified as the cause of formation of two new classes of process-related oligonucleotide impurities containing a DMTr-C-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48931352b7dd213f04cb38f064c47fc6
https://doi.org/10.1016/j.bmcl.2004.06.088
https://doi.org/10.1016/j.bmcl.2004.06.088
Autor:
James V. McArdle
Residual solvents comprise one of the classes of potential impurities in drug products. For most residual solvents, sufficient toxicological data exist to allow solvents to be classified according to their toxicological potential. The most toxic solv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6174e4f2ce3d18ce9f5c8065a0aca150
https://doi.org/10.1016/b978-0-08-098350-9.00007-2
https://doi.org/10.1016/b978-0-08-098350-9.00007-2
Autor:
Daniel W. Armstrong, James Bergum, Beth Ann Brescia, Peter Bryan, Todd L. Cecil, Ping Chen, Eliza N. Fung, Vivian A. Gray, Brian He, Laureen E. Little, David K. Lloyd, James V. McArdle, Kurt L. Moyer, Bradford J. Mueller, Nilusha L.T. Padivitage, Ernest Parente, Robyn L. Phelps, Shelley R. Rabel Riley, Christopher M. Riley, Thomas W. Rosanske, James Scull, Krzysztof Selinger, Eric B. Sheinin, Pamela A. Smith, Jonathan P. Smuts, Patrick A. Tishmack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::189c3cdf8d856264725f8cc2505af9d0
https://doi.org/10.1016/b978-0-08-098350-9.01002-x
https://doi.org/10.1016/b978-0-08-098350-9.01002-x
Autor:
Drake S. Eggleston, Usha B. Nair, Daniel W. Armstrong, Yasir Y. Rawjee, James V. McArdle, Samuel S.C. Chang
Publikováno v:
Chirality. 8:590-595
Vancomycin forms a stable complex with Cu2− in neutral aqueous solutions. The enantioselectivity of native vancomycin was compared to that of the copper-vancomycin complex using capillary electrophoresis (CE). There were significant differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::777262ae8a07baa833abc023580c4b7b
https://doi.org/10.1002/(sici)1520-636x(1996)8:8<590::aid-chir9>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1996)8:8<590::aid-chir9>3.0.co
Autor:
E. McCafferty, James V. McArdle
Publikováno v:
Journal of The Electrochemical Society. 142:1447-1453
Four siderophores isolated from bacteria have been studied as possible corrosion inhibitors for iron in deaerated 1N HCl. These compounds are aerobactin, enterobactin, parabactin, and rhodotorulic acid. Polarization measurements and ac impedance stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e7f30989e038417a9ab565396667db
https://doi.org/10.1149/1.2048595
https://doi.org/10.1149/1.2048595
Autor:
Paul W. Oxley, Robert Gordon Smithkline Beecham Pharmac. Giles, Sean McCrossen, James V. McArdle
Publikováno v:
Journal of Chromatography A. 623:229-235
Di-N- n -propylamine (DNP) is used in the final step of the synthesis of ropinirole (SK&F 101468-A). Trace impurities in DNP give rise to significant impurities in the raw drug substances. A high-performance liquid chromatographic (HPLC) method for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b63e2a65bf47e7ff518468f30d4dc94
https://doi.org/10.1016/0021-9673(92)80362-x
https://doi.org/10.1016/0021-9673(92)80362-x