Zobrazeno 1 - 10
of 45
pro vyhledávání: '"JAMES S. MACDONALD"'
Autor:
James S. MacDonald, Harvey E. Scribner
Publikováno v:
Carcinogenicity ISBN: 9781003067641
Carcinogenicity
Carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bafb32adeb489d6fa74912f222ace9c
https://doi.org/10.1201/9781003067641-4
https://doi.org/10.1201/9781003067641-4
Autor:
Eitan Pludwinski, Cheul H. Cho, James S. MacDonald, Amit Parekh, Jacquelyn Dwyer, Zaid Jayyosi, Robert Freedman, Eric Novik, Anil B. Shrirao, James K. Morelli
Publikováno v:
Toxicology and Applied Pharmacology. 336:20-30
The failure of drug candidates during clinical trials and post-marketing withdrawal due to Drug Induced Liver Injury (DILI), results in significant late-stage attrition in the pharmaceutical industry. Animal studies have proven insufficient to defini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0fdff9ac167e7fc0da3c5d8b6c8abfb
https://doi.org/10.1016/j.taap.2017.09.013
https://doi.org/10.1016/j.taap.2017.09.013
Autor:
James S MacDonald, Richard Peck, Mark VanArendonk, David B. Huang, Catherine D Strader, Thomas L. Holland
Publikováno v:
Open Forum Infectious Diseases
New antibiotics are needed because of the increased morbidity and mortality associated with multidrug-resistant bacteria. Iclaprim, a bacterial dihydrofolate reductase inhibitor, not currently approved, is being studied for the treatment of skin infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57ca8dec12bd426486c622331cd319e
http://europepmc.org/articles/PMC5798018
http://europepmc.org/articles/PMC5798018
Autor:
Franck A. Atienzar, Helga Gerets, Eric Novik, Claude Delatour, Alvaro Cardenas, Martin L. Yarmush, Amit Parekh, James S. MacDonald, Stephane Dhalluin
Publikováno v:
Toxicology and Applied Pharmacology. 275:44-61
Drug Induced Liver Injury (DILI) is a major cause of attrition during early and late stage drug development. Consequently, there is a need to develop better in vitro primary hepatocyte models from different species for predicting hepatotoxicity in bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd1033c7f82b940dca2fd902fa95a1e
https://doi.org/10.1016/j.taap.2013.11.022
https://doi.org/10.1016/j.taap.2013.11.022
Autor:
Raegan O’Lone, Michael P. Holsapple, James H. Kim, Ronald N. Hines, Nancy G. Doerrer, Marc S Bonnefoi, Jan Willem van der Laan, Syril D Pettit, Dennis Devlin, Ernest S Harpur, Sally S. Tinkle, Scott E. Belanger, Ayako S Takei, James L. Stevens, James S. MacDonald, Michelle R. Embry, Shoji Fukushima
Publikováno v:
Critical Reviews in Toxicology. 40:893-911
The public health and environmental communities will face many challenges during the next decade. To identify significant issues that might be addressed as part of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd025708ef3d6f6667a51056f384b2e5
https://doi.org/10.3109/10408444.2010.506640
https://doi.org/10.3109/10408444.2010.506640
Publikováno v:
Toxicologic Pathology. 32:26-41
The discovery that 3-hydroxy-3-methyglutaryl coenzyme A reductase was a rate-determining step in the biosynthesis of cholesterol led to the discovery of inhibitors of this enzyme. To support the development of these agents (statins) as potential hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf36ec51ec2a64e33839eccf46877507
https://doi.org/10.1080/01926230490462057
https://doi.org/10.1080/01926230490462057
Autor:
Jay I. Goodman, Richard D. Storer, Peter Kasper, Douglas A. Keller, Abigail Jacobs, Ronald J. Gerson, Gerald G. Long, John E. French, Tohru Inoue, Amy L. Lavin, James S. MacDonald, Bruce McCullough, Frank D. Sistare, Jan Willem van der Laan
Publikováno v:
Toxicological Sciences. 77:188-194
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1d01af48b5a8bb8b6dbe956d70f54f7
https://doi.org/10.1093/toxsci/kfh037
https://doi.org/10.1093/toxsci/kfh037
Publikováno v:
Genotoxicity and Carcinogenicity Testing of Pharmaceuticals ISBN: 9783319220833
The assessment of risk to humans of cancer following exposure to chemicals has been a challenging process for decades. The early pragmatic approaches to this important challenge have evolved with growing understanding of the underlying biology of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b5d2dabc607dd20e3b10353d98cad2
https://doi.org/10.1007/978-3-319-22084-0_6
https://doi.org/10.1007/978-3-319-22084-0_6
Autor:
James E. Patrick, Christopher Horvath, Richard E. Morrissey, Eileen A. Snyder, James S. MacDonald
Publikováno v:
Toxicological Sciences. 65:266-275
SCH 58500 is a replication-defective recombinant adenoviral vector containing the cloned human wild-type (normal) tumor suppressor gene p53. SCH 58500 is in trials to evaluate potential clinical utility. A series of toxicology studies in rats and mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2776e1ef299c13a5264ea73834bac07d
https://doi.org/10.1093/toxsci/65.2.266
https://doi.org/10.1093/toxsci/65.2.266
Autor:
James S. MacDonald, Denise Robinson
Publikováno v:
Toxicologic Pathology. 29:13-19
The willingness of the agencies involved in the regulation of pharmaceuticals to accept data from newly proposed models for carcinogenicity testing (eg, transgenic animals, neonatal rodent models, initiation-promotionmodels) has stimulated internatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86ef04589f5458e7709d9f9ce4df0ce6
https://doi.org/10.1080/019262301753178438
https://doi.org/10.1080/019262301753178438