Zobrazeno 1 - 10
of 1 258
pro vyhledávání: '"JAK3"'
Autor:
Abdelmoujoud Faris, Ivana Cacciatore, Radwan Alnajjar, Adnane Aouidate, Mohammed H. AL Mughram, Menana Elhallaoui
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
The Janus kinase 3 (JAK3) family, particularly JAK3, is pivotal in initiating autoimmune diseases such as rheumatoid arthritis. Recent advancements have focused on developing antirheumatic drugs targeting JAK3, leading to the discovery of novel pyraz
Externí odkaz:
https://doaj.org/article/d48cbf8cb96f4e7e98a86152d89af184
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-8 (2024)
Abstract Background Small intestinal monomorphic–epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma originating in the gastrointestinal tract. This study aimed to investigate the clinicopathological features, im
Externí odkaz:
https://doaj.org/article/77bbb67ba48e4cb3aac412d895e0c02d
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1841 (2024)
Atopic dermatitis is a chronic inflammatory dermatosis characterized by pruritic, scaly, erythematous lesions. Its incidence varies but is estimated to be approximately 20% in children and between 7 and 14% in adults, with variation amongst countries
Externí odkaz:
https://doaj.org/article/067d93e57bc044a681d157a966040c80
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTBackground: T-prolymphocytic leukemia (T-PLL) is an aggressive hematologic malignancy. A portion of patients can be cured with alemtuzumab induction followed by allogeneic hematopoietic stem cell transplant, but patients who relapse after tra
Externí odkaz:
https://doaj.org/article/2fab398806a24985a9f7976cb6305edf
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22085- (2023)
Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important steps required to generate retroviral particles for the stable expression of mutant JAK3 constr
Externí odkaz:
https://doaj.org/article/6a03e7aa03c54534a97e5458b746fd59
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
The JAKs protein family is composed of four isoforms, and JAK3 has been regarded as a druggable target for the development of drugs to treat various diseases, including hematologic tumors, cancer, and neuronal death. Therefore, the discovery of JAK3
Externí odkaz:
https://doaj.org/article/9430dbcc5edb4d9e8cae17e1aa9ffaf3
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2977 (2024)
The Janus kinase (JAK) family is a small group of protein tyrosine kinases that represent a central component of intracellular signaling downstream from a myriad of cytokine receptors. The JAK3 family member performs a particularly important role in
Externí odkaz:
https://doaj.org/article/edd979fbe39d4003bffad918b5dadfda
Autor:
Fatih M. Uckun, Sanjive Qazi
Publikováno v:
Onco, Vol 2, Iss 4, Pp 282-304 (2022)
Our main objective was to identify abundantly expressed tyrosine kinases in multiple myeloma (MM) as potential therapeutic targets. We first compared the transcriptomes of malignant plasma cells from newly diagnosed MM patients who were risk-categori
Externí odkaz:
https://doaj.org/article/fecaae7bb49249789bd2dc8382b09460
Autor:
Lu Liu, Risong Na, Lianjuan Yang, Jixiang Liu, Yingjia Tan, Xi Zhao, Xuri Huang, Xuecheng Chen
Publikováno v:
Molecules, Vol 28, Iss 20, p 7140 (2023)
The drug development process suffers from low success rates and requires expensive and time-consuming procedures. The traditional one drug–one target paradigm is often inadequate to treat multifactorial diseases. Multitarget drugs may potentially a
Externí odkaz:
https://doaj.org/article/76396e638ee74de6b7bec6aa98e50e7b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.