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Akademický článek

L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice

Autor: Qi Li, Jiaqi Ding, Boyu Xia, Kun Liu, Koulong Zheng, Jingjing Wu, Chao Huang, Xiaomei Yuan, Qingsheng You

Publikováno v: Molecular Medicine, Vol 30, Iss 1, Pp 1-12 (2024)

Abstract Background L-theanine is a unique non-protein amino acid in tea that is widely used as a safe food additive. We investigated the cardioprotective effects and mechanisms of L-theanine in myocardial ischemia-reperfusion injury (MIRI). Methods

Externí odkaz: https://doaj.org/article/fd4944df3bfc411eb0f8546a11452a37

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Akademický článek

The role of aspirin in with breast cancer patients receiving neoadjuvant chemotherapy by targeting JAK2/ STAT3

Autor: Zheng, Yajuan, Tang, Hongchao, Zheng, Qinghui, Guan, Dandan, Mo, Qiuping ^∗

Publikováno v: In Journal of Radiation Research and Applied Sciences December 2023 16(4)

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Akademický článek

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Akademický článek

Lavender protects H9c2 cardiomyocytes against oxygen-glucose deprivation (OGD)-induced injury via targeting the JAK2/STAT3 pathway

Autor: Shaghayegh Askarian-Amiri, Hoda Fotovat eskandari, Fatemeh Ramezani, Gelare Vahabzadeh, Nahid Aboutaleb

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 25, Iss 2, Pp 263-267 (2022)

Objective(s): This study was conducted to examine the therapeutic effects of lavender oil (LO) against oxygen-glucose deprivation (OGD)-induced injury in vitro model.Materials and Methods: In this study, the OGD model was induced in the H9C2 cell lin

Externí odkaz: https://doaj.org/article/b6e4e0e00dc94735aa64225438a12aa5

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Akademický článek

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Akademický článek

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Sesquiterpene lactones isolated from Carpesium abrotanoides L. by LC–MS combined with HSCCC inhibit liver cancer through suppression of the JAK2/STAT3 signaling pathway

Autor: Tang Chunyu, Dan Wan, Huanghe Yu, Shuihan Zhang, Yupei Yang, Wang Xionglong, Bingbing Shen, Cai Yuan, Daifeng Tang

Publikováno v: Medicinal Chemistry Research. 31:436-445

Carpesium abrotanoides L. is rich in sesquiterpene lactones, the experiments of anti-tumor activity in vitro showed that total sesquiterpene lactone extracts exhibited the most cytotoxicity activities against HepG-2 cells (IC50 = 4.2 μg/mL). In orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a64e12265dbda12ec12dc5b0818868
https://doi.org/10.1007/s00044-021-02838-y

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MiR-189 Exerts Anticancer Activity Through Janus Kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) Pathway in Non-Small Cell Lung Cancer

Autor: Qing Hu, Feng Li, Ying Qu, Xiaoran Li, Hongyun Ji, Hui Lu

Publikováno v: Journal of Biomaterials and Tissue Engineering. 11:2421-2426

Non-small cell lung cancer (NSCLC) remains a threat to human health but its etiology remains unclear. MicroRNAs (miRNAs) are involved in NSCLC progression. This study aims to elucidate the mechanism by how exosomal miR-189 functions in NSCLC. After i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56190f35052664c7da4f4cacfd168d54
https://doi.org/10.1166/jbt.2021.2846

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Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway

Autor: Wei Wang, Shandong Ye, Wan Zhou

Publikováno v: World Journal of Diabetes. 12:466-479

Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a38aac205b0aec3e70635378fab92e8
https://doi.org/10.4239/wjd.v12.i4.466

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Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells

Autor: Madhu B. Anand-Srivastava, Yuan Li, Ekhtear Hossain

Publikováno v: Canadian Journal of Physiology and Pharmacology. 99:237-246

We earlier showed that angiotensin (Ang) II-induced overexpression of Giα proteins contributes to the hyperproliferation of vascular smooth muscle cells (VSMC). In addition, the implication of the JAK2/STAT3 pathway in Ang II-induced hyperproliferat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13788c6d89efcc1715c2a0ff056400a6
https://doi.org/10.1139/cjpp-2020-0415

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