Zobrazeno 1 - 10
of 381
pro vyhledávání: '"JAK2/STAT3 signaling pathway"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Background Existing studies have already revealed the involvement of C–C chemokine receptor type 7 (CCR7) in diverse human cancers, including esophageal cell squamous carcinoma (ESCA). Our current study, aims to explore the relevant mechan
Externí odkaz:
https://doaj.org/article/d97d2de964894022a93522b37906ba63
Publikováno v:
Biological Procedures Online, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract To explore the effects and mechanisms of the Xianhecao-Huanglian drug pair on autophagy-mediated intervention in acute inflammatory bowel disease (IBD) via the JAK2/STAT3 pathway. The study examined the underlying mechanisms of action of Xia
Externí odkaz:
https://doaj.org/article/7ce71fc06adf48a4bacccbd27eea4dff
Autor:
Fengxia CHEN, Feifei PU
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 7, Pp 554-560 (2024)
ObjectiveTo investigate the effect of folic acid–modified liposome quercetin (FLQ) on the proliferation and apoptosis of triple negative breast cancer (TNBC) cells and explore its underlying mechanism. MethodsCCK-8 was used to detect the effect of
Externí odkaz:
https://doaj.org/article/68e92d828f4446f4a3477baf0e8b046a
Autor:
Jianxian Xiong, Jiayuan Ling, Jie Yan, Yanyu Duan, Junjian Yu, Wentong Li, Wenbo Yu, Jianfeng Gao, Dilin Xie, Ziyou Liu, Yongzhi Deng, Yongling Liao
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Aortic dissection (AD) is a life-threatening condition with a high mortality rate and without effective pharmacological therapies. Our previous study illustrated that leukocyte immunoglobulin-like receptor B4 (LILRB4) knockdown promoted the
Externí odkaz:
https://doaj.org/article/e6e1ef1473a24cf9a5352a0a58d49b36
Autor:
Xinlei Zhao, Jiaxuan Zhou, Yanqing Liu, Jianguo Wang, Youcai Liu, Beiyu Wang, Caiting Han, Shengjie Zhao, Yijun Zhang
Publikováno v:
Biomolecules & Biomedicine (2024)
Osteoporosis (OP) is a common chronic progressive bone disease that increases fracture risk in postmenopausal women. Research suggests that puerarin (Pue) may be an effective treatment for OP. This study examined the effects and underlying mechanisms
Externí odkaz:
https://doaj.org/article/3621fe86d67f4e7089729572174112ec
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 50, Iss 12, Pp 1191-1196 (2023)
Objective To investigate the influence of limonin on the malignant biological behavior of non-small cell lung cancer (NSCLC) cells by regulating the protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling
Externí odkaz:
https://doaj.org/article/52ef41da65204fadaa7b2bc418cd2c5b
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 272, Iss , Pp 116069- (2024)
Di-(2-ethylhexyl) phthalate (DEHP), a common endocrine-disrupting chemical (EDC), is widely used in daily articles, early exposure to DEHP is associated with many behavioral changes in pups. This study aimed to investigate the effects and underlying
Externí odkaz:
https://doaj.org/article/058852daa93b4745bd8d93bfc7a77645
Autor:
Xinru Wang, Rumeng Ding, Zhe Fu, Meng Yang, Duolu Li, Yubing Zhou, Chongzhen Qin, Wenda Zhang, Liuzhe Si, Jingmin Zhang, Yuna Chai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and objective: Osteosarcoma is a common primary malignant tumor of bone, and doxorubicin is one of the most widely used therapeutic drugs. While the problem of doxorubicin resistance limits the long-term treatment benefits in osteosarcoma
Externí odkaz:
https://doaj.org/article/79f9c6924f4c4ff7880219e632d0adba
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 11, Pp 8687-8703 (2023)
Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is t
Externí odkaz:
https://doaj.org/article/e22735d0e2eb4e54914a2790c14c10ca
Autor:
Lijun Ji, Shuaijie Lou, Yi Fang, Xu Wang, Weiwei Zhu, Guang Liang, Kwangyoul Lee, Wu Luo, Zaishou Zhuang
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 631 (2024)
Diabetic cardiomyopathy (DCM) represents a common pathological state brought about by diabetes mellitus (DM). Patchouli alcohol (PatA) is known for its diverse advantageous effects, notably its anti-inflammatory properties and protective role against
Externí odkaz:
https://doaj.org/article/8b966ab3bb23425cb784eda6abadba45