Zobrazeno 1 - 10
of 194
pro vyhledávání: '"JAK-STAT signalling"'
Autor:
Ki-Kwang Oh, Sang-Jun Yoon, Seol Hee Song, Jeong Ha Park, Jeong Su Kim, Min Ju Kim, Goo-Hyun Kwon, Dong Joon Kim, Ki-Tae Suk
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 52, Iss 1, Pp 500-511 (2024)
Currently, the treatment of hepatocellular carcinoma (HCC) is yet to be determined, alternatively, flavonoids or alkaloids from nature have been considered as significant mediators against HCC. In the scenario, we pioneered the most significant agent
Externí odkaz:
https://doaj.org/article/7000f788b7974655abb813f2f5544a51
Autor:
Md Mehedi Hossain, Arfan Khalid, Zaheen Akhter, Sabra Parveen, Mir Owais Ayaz, Aadil Qadir Bhat, Neetu Badesra, Farheen Showket, Mohmmad Saleem Dar, Farhan Ahmed, Sumit Dhiman, Mukesh Kumar, Umed Singh, Razak Hussain, Pankaj Keshari, Ghulam Mustafa, Amit Nargorta, Neha Taneja, Somesh Gupta, Riyaz A. Mir, Aravind Singh Kshatri, Utpal Nandi, Nooruddin Khan, P. Ramajayan, Govind Yadav, Zabeer Ahmed, Parvinder Pal Singh, Mohd Jamal Dar
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target for drug discovery because it only regulates a narrow spectrum
Externí odkaz:
https://doaj.org/article/64faa3ccd8d24a228b59d9fca5872f55
Bioinformatic meta-analysis reveals novel differentially expressed genes and pathways in sarcoidosis
Autor:
Rogier T. A. van Wijck, Hari S. Sharma, Sigrid M. A. Swagemakers, Willem A. Dik, Hanna IJspeert, Virgil A. S. H. Dalm, Paul L. A. van Daele, P. Martin van Hagen, Peter J. van der Spek
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionSarcoidosis is a multi-system inflammatory disease of unknown origin with heterogeneous clinical manifestations varying from a single organ non-caseating granuloma site to chronic systemic inflammation and fibrosis. Gene expression studie
Externí odkaz:
https://doaj.org/article/f8a6d8e6b3d74c478ef8b365b23c0637
Publikováno v:
Cells, Vol 13, Iss 2, p 133 (2024)
Lung macrophage (LM) is vital in host defence against bacterial infections. However, the influence of other innate immune cells on its function, including the polarisation of different subpopulations, remains poorly understood. This study examined th
Externí odkaz:
https://doaj.org/article/2c07c7e8c9094a60843638d20319af0b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Unphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression profile as compared to tyrosine-phosphorylated STAT1 (P-STAT1) homodimers. However, the impact of
Externí odkaz:
https://doaj.org/article/616275c055264bdfbdc779cfddf93301
Autor:
Ifeanyi Jude Ezeonwumelu, Edurne García-Vidal, Eudald Felip, Maria C. Puertas, Bruna Oriol-Tordera, Lucía Gutiérrez-Chamorro, André Gohr, Marta Ruiz-Riol, Marta Massanella, Bonaventura Clotet, Javier Martinez-Picado, Roger Badia, Eva Riveira-Muñoz, Ester Ballana
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contrib
Externí odkaz:
https://doaj.org/article/0c134c9371f546d1bf28e34f8645f39a
Autor:
Jiaqi Wang, Yi Zhang, Hu Song, Hang Yin, Tao Jiang, Yixin Xu, Lianyu Liu, Hongyu Wang, Hong Gao, Renhao Wang, Jun Song
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-20 (2021)
Abstract Background Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and development of various diseases. However, the biological functions of circRNAs in colorectal cancer (CRC) are largely
Externí odkaz:
https://doaj.org/article/4101756b7fb841c98ee56a12f0849bf1
Autor:
Yi-Fang Chen, Jin-Juan Zheng, Chao Qu, Yao Xiao, Fang-Fang Li, Quan-Xin Jin, Hong-Hua Li, Fan-Ping Meng, Gui-Hua Jin, Dan Jin
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 757-766 (2019)
Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease, and is related to imbalance of CD4+T subsets. However, the current treatments of chronic colitis are not ideal and have potential side effects. Therefore, more effective
Externí odkaz:
https://doaj.org/article/48135dec516d46f5927ce00786c20247
Autor:
Tianwen Zhu, Xiaohui Gong, Fei Bei, Li Ma, Jingjing Sun, Jian Wang, Gang Qiu, Jianhua Sun, Yu Sun, Yongjun Zhang
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract Objectives The present phenotype‐based disease classification causes ambiguity in diagnosing and determining timely, effective treatment options for primary immunodeficiency (PID). In this study, we aimed to examine the characteristics of
Externí odkaz:
https://doaj.org/article/7738aeb78e024f1182deef575056c3ce