Zobrazeno 1 - 10
of 5 045
pro vyhledávání: '"JAK - STAT signaling pathway"'
Publikováno v:
Türk Biyokimya Dergisi, Vol 49, Iss 5, Pp 637-646 (2024)
Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignant tumor. Studies have demonstrated that JAK/STAT signaling is activated in many types of cancer. In addition, JAK/STAT is activated downstream of AXL, and the AXL receptor is activate
Externí odkaz:
https://doaj.org/article/ee995ba0618a492089b90f25789f5983
Autor:
Zhenying Fan, Yajuan Hou, Yue Liu, Jingjing Zhao, Yixiao Wang, Chun Fu, Shuangfeng Wang, Junwei Wang, Yongli Guo, Mingchun Gao
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
Interferon-αs (IFN-αs) are crucial cytokines for inducing protective antiviral responses. The baculovirus-mediated gene transduction of mammalian cells (BacMam) is an efficient delivery tool for recombinant protein expression in mammalian cells. Th
Externí odkaz:
https://doaj.org/article/1c261ee03b6b4c548c7e9bb379bfd096
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and PurposeThe damage or apoptosis of retinal ganglion cells (RGCs) is one of the leading causes of various blinding eye diseases, such as glaucoma, diabetic retinopathy, optic neuritis, and ischemic optic neuropathy. Oxidative stress is i
Externí odkaz:
https://doaj.org/article/2a673f3dfec746a2a424e20def7e90fc
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-10 (2024)
Abstract Objective The aim of this study was to investigate the role and mechanisms of miR-155 in chronic spontaneous urticaria (CSU). Methods The expression level of miR-155 in the skin tissues of patients with CSU and experimental rats were detecte
Externí odkaz:
https://doaj.org/article/08c546383dd44caabd6ec83517cce152
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed to explore the mechanism of how wogonin regulated high glucose (HG)-induced renal cell inj
Externí odkaz:
https://doaj.org/article/57a359c3a72c4acaae18284da3c85cb4
Autor:
Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathw
Externí odkaz:
https://doaj.org/article/48566023b44448ebb7eacf9551d6b4dd
Autor:
Wenshuang Wang, Yanhong Ji, Zhexu Dong, Zheran Liu, Shuang Chen, Lei Dai, Xiaolan Su, Qingyuan Jiang, Hongxin Deng
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background Neural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural tube during early embryonic development. Neuroinflammation refers to the inflammatory respon
Externí odkaz:
https://doaj.org/article/c9fbe556209f490d9b8874959c145d19
Autor:
Dong Liang, Qiaoli Wang, Wenbiao Zhang, Hailin Tang, Cailu Song, Zhimin Yan, Yang Liang, Hua Wang
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Over the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F m
Externí odkaz:
https://doaj.org/article/073783ba1af74fbeb981ff0ef2bd4dea
Autor:
Chenxi Zhao, Tiangang Zhou, Ming Li, Jie Liu, Xiaoqing Zhao, Yilin Pang, Xinjie Liu, Jiawei Zhang, Lei Ma, Wenxiang Li, Xue Yao, Shiqing Feng
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 2, Pp 434-439 (2024)
Argatroban is a synthetic thrombin inhibitor approved by U.S. Food and Drug Administration for the treatment of thrombosis. However, whether it plays a role in the repair of spinal cord injury is unknown. In this study, we established a rat model of
Externí odkaz:
https://doaj.org/article/68afc8c9c5b94fb597e819fb89a2b3fe
Autor:
Zhuowei Li, Junjun Wang, Siyu Wang, Wei Zhao, Xiaolin Hou, Jianfang Wang, Hong Dong, Shuanghai Zhou, Yuan Gao, Wei Yao, Huanrong Li, Xuewei Liu
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) causes substantial economic losses in the global swine industry. The current vaccine options offer limited protection against PRRSV transmission, and there are no effective comme
Externí odkaz:
https://doaj.org/article/ba35a7918c9c4b51a1ff0c83ebbe1d8d