Emerging Topical and Systemic JAK Inhibitors in Dermatology

Autor: Farzan Solimani, Katharina Meier, Kamran Ghoreschi

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders. Here, th

Externí odkaz: https://doaj.org/article/8200ff9572dc49c09c395208a69d4c79

Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic PharmacokineticsSummary

Autor: Andreas Zollner, Nicole Przysiecki, Sophie Macheiner, Vera Reinstadler, Barbara Jelusic, Simon J. Reider, Herbert Tilg, Christina Watschinger, Alexandra Pfister, Herbert Oberacher, Alexander R. Moschen, Bernhard Texler

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 383-404 (2022)
Cellular and Molecular Gastroenterology and Hepatology

Objective By interfering with multiple cytokines, human Janus kinase inhibitors (JAKis) are of growing importance in the treatment of malignant and inflammatory conditions. Although tofacitinib has demonstrated efficacy as the first-in-class JAKi in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e0dffe3ffcc5c8d849bd534a91dfc
http://www.sciencedirect.com/science/article/pii/S2352345X21001922

Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy

Autor: Hao Wang, Lei Wang, Keyi Jia, Yu Liu, Sha Zhao, Wei Li, Caicun Zhou, Minlin Jiang, Bin Chen, Yayi He

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2983-2994 (2021)

Genomic instability remains an enabling feature of cancer and promotes malignant transformation. Alterations of DNA damage response (DDR) pathways allow genomic instability, generate neoantigens, upregulate the expression of programmed death ligand 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe73202674a833d134ec811bcbf7332
https://doi.org/10.1016/j.apsb.2021.01.003

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Autor: David A. Frank, Isidora Tošić

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436

Lessons from pathophysiology: Use of individualized combination treatments with immune interventional agents to tackle severe respiratory failure in patients with COVID-19

Autor: Konstantinos Leventogiannis, Vasiliki Lygoura, Anastasia Michail, Anna Samakidou, Nikolaos K. Gatselis, Evangelos J. Giamarellos-Bourboulis, Stella Gabeta, Efthymia Petinaki, Marianna Vlychou, Sarah P. Georgiadou, Aggelos Stefos, George N. Dalekos, George Ntaios, George Giannoulis

Publikováno v: European Journal of Internal Medicine

Aims Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may lead to the development of severe respiratory failure. In hospitalized-patients, prompt interruption of the virus-driven inflammatory process by using combination trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeb4d901f0603ee9f7a8f8a76a3ddcf
https://doi.org/10.1016/j.ejim.2021.03.026