Zobrazeno 1 - 10
of 274
pro vyhledávání: '"JAE-KYUNG LEE"'
Autor:
Stephen Weber, Kelly B. Menees, Jieun Park, Julian Agin-Liebes, Chih-Chun Lin, Roy N. Alcalay, Jae-Kyung Lee
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Mounting data suggest an important role for the immune system in Parkinson’s disease (PD). Previous evidence of increased natural killer (NK) cell populations in PD suggests a potential role of NK cells in the pathogenesis of the disease.
Externí odkaz:
https://doaj.org/article/a402035f904947c891211efc4e6ed5ec
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Microglia play a critical role in maintaining brain homeostasis but become dysregulated in neurodegenerative diseases. Regulator of G-protein Signaling 10 (RGS10), one of the most abundant homeostasis proteins in microglia, decreases with aging and f
Externí odkaz:
https://doaj.org/article/6b7916ebb4054de5bb6d2b501dca8f66
Autor:
Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter, Jae-Kyung Lee
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-biased. For example,
Externí odkaz:
https://doaj.org/article/5d941ca1cc154dc19e710e3142783f80
Autor:
Rachael H. Earls, Jae-Kyung Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1517-1525 (2020)
Parkinson’s disease: How natural killer cells can help Understanding the roles that inflammation and immune cells called natural killer (NK) cells play in Parkinson’s disease (PD) may help in finding new treatments. In PD, a neurodegenerative dis
Externí odkaz:
https://doaj.org/article/cc755227ecea45e795b540891cdfb23d
Publikováno v:
IEEE Access, Vol 8, Pp 149999-150009 (2020)
Fault diagnosis of power transmission systems (PTSs) is crucial for ensuring the reliability of power grids because most grids are exposed to harsh environments. For integrity diagnosis of PTSs, this article proposes a nondestructive patrol inspectio
Externí odkaz:
https://doaj.org/article/286a3aa395884fe6b2089bfe2a67cc30
Autor:
Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G. Hazim, Jae-Kyung Lee
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Parkinson’s disease (PD) is characterized by the accumulation of alpha-synuclein (α-syn) inclusions, the major component of Lewy bodies. Extracellular α-syn aggregates act as a damage-associated molecular pattern (DAMP) and the presence
Externí odkaz:
https://doaj.org/article/05bb54c44a8d4ced913f1027e33cbea1
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Seasonal influenza epidemics represent a significant global health threat. The exacerbated immune response triggered by respiratory influenza virus infection causes severe pulmonary damage and contributes to substantial morbidity and mortality. Regul
Externí odkaz:
https://doaj.org/article/7661ed6188944f50ba6842fab49760bf
Autor:
Fiona E. McAlpine, Jae-Kyung Lee, Ashley S. Harms, Kelly A. Ruhn, Mathew Blurton-Jones, John Hong, Pritam Das, Todd E. Golde, Frank M. LaFerla, Salvatore Oddo, Armin Blesch, Malú G. Tansey
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 1, Pp 163-177 (2009)
Microglial activation and overproduction of inflammatory mediators in the central nervous system (CNS) have been implicated in Alzheimer's disease (AD). Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have been reported i
Externí odkaz:
https://doaj.org/article/7e22b35e528c47e385f58454a8e763ae
Critical role of regulator G-protein signaling 10 (RGS10) in modulating macrophage M1/M2 activation.
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81785 (2013)
Regulator of G protein signaling 10 (RGS10), a GTPase accelerating protein (GAP) for G alpha subunits, is a negative regulator of NF-κB in microglia. Here, we investigated the role of RGS10 in macrophages, a closely related myeloid-derived cell type
Externí odkaz:
https://doaj.org/article/ea99784166514d88945257448f8114bf
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23660 (2011)
Inflammation and oxidative stress have been implicated in the pathophysiology of Parkinson's disease (PD) and inhibition of microglial activation attenuates degeneration of dopaminergic (DA) neurons in animal models of PD. Loss-of-function mutations
Externí odkaz:
https://doaj.org/article/19fbc2bad9e34893bfeb3afba3b13690