Zobrazeno 1 - 10
of 86
pro vyhledávání: '"JA Gracie"'
Autor:
P W Ferrell, Hilary Wilson, D Baxter, M. E. Perry, Lynette Dunning, JA Gracie, Anne Crilly, Mohammad B. Nickdel, William R. Ferrell, James Dale, E Burns, John C. Lockhart, Iain B. McInnes, Jagtar Singh Nijjar
Publikováno v:
Annals of the Rheumatic Diseases. 71:1049-1054
Proteinase-activated receptor 2 (PAR(2)) is a G protein-coupled receptor activated by serine proteinases with proinflammatory activity. A study was undertaken to investigate the presence and functional significance of PAR(2) expression on rheumatoid
Autor:
William R. Ferrell, Lynette Dunning, Iain B. McInnes, Robin Plevin, Gary Boyd, John C. Lockhart, JA Gracie
Publikováno v:
Rheumatology. 48:i35-i40
Background: Protease-activated receptor-2 (PAR-2) is one member of a family of G-protein coupled receptors which is activated by N-terminus cleavage by serine proteases to reveal a unique tethered ligand. We previously demonstrated that PAR-2 plays a
Publikováno v:
AIDS. 19:1907-1910
Kaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus (KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain of human immunoglobulin G1 to create vOX2:Fc, suppressed neutrophil oxidati
Autor:
J Murdoch, Noriko Koyama, A Schobel, F McGarry, JA Gracie, Max Field, Rajan Madhok, Burkhard Möller, Anne Crilly, Iain B. McInnes, Jörn Pons-Kühnemann
Publikováno v:
Genes & Immunity. 6:211-216
Interleukin (IL)-18 is an important mediator of innate and adaptive immunity. We searched for an association of IL-18 promoter single-nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) in Caucasians. The entire study population was compose
Publikováno v:
Immunology Today. 21:312-315
The wide-ranging effects of interleukin 18 as a regulator of innate and acquired immune responses, and particularly its role in human autoimmune diseases, suggest its potential importance as a therapeutic target.
Autor:
Eleanor M. Bolton, F. Y. Liew, D. J. Orr, Fang-Ping Huang, JA Gracie, J. J. Casey, J A Bradley, Xiao-Qing Wei
Publikováno v:
Transplantation. 64:589-593
BACKGROUND: During allograft rejection, up-regulation of cytokine-inducible nitric oxide synthase (iNOS) leads to the production of large amounts of nitric oxide (NO). The net effect of NO on the alloimmune response is, however, difficult to predict
Autor:
Syed Faisal Ahmed, P. Galea, Iain B. McInnes, JA Gracie, Vicky E MacRae, Sze Choong Wong, Janet Gardner-Medwin
Publikováno v:
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 18(5)
Objective To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA. Design This is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocen
Autor:
A. Boitelle, Lamyaa Al-Riyami, Katrina M. Houston, Caitlin Egan, T. Thalhamer, Dorothy E. Kean, William Harnett, Iain B. McInnes, Christina N. Steiger, Marcos J. C. Alcocer, JA Gracie, S. McGuiness, Margaret M. Harnett
Publikováno v:
Annals of the rheumatic diseases. 67(4)
Objective:In countries where parasitic infections are endemic, autoimmune disease is relatively rare, leading to the hypothesis that parasite-derived immunomodulators may protect against its development. Consistent with this, we have previously demon
Publikováno v:
Arthritis Research
We have recently demonstrated the presence and involvement of IL-18 in rheumatoid arthritis (RA) synovitis. Moreover, blockade of IL-18 in vivo is protective in arthritis models. We sought to demonstrate for the first time the production and intracel
Publikováno v:
Arthritis Research