Výsledky vyhledávání - "J.W. van der Laan"

Akademický článek

Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression

Autor: M.M. Heldring, B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. Beltman

Publikováno v: Heliyon, Vol 10, Iss 21, Pp e38406- (2024)

Various groups of chemicals that we encounter in every-day life are known to disrupt the endocrine system, such as estrogen mimics that can disturb normal cellular development and homeostasis. To understand the effect of estrogen on intracellular pro

Externí odkaz: https://doaj.org/article/8415a89bd51f4a6f806365b1560ad3b9

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Akademický článek

Recapitulating Cholangiopathy-Associated Necroptotic Cell Death In Vitro Using Human Cholangiocyte OrganoidsSummary

Autor: Shaojun Shi, Monique M.A. Verstegen, Henk P. Roest, Arif I. Ardisasmita, Wanlu Cao, Floris J.M. Roos, Petra E. de Ruiter, Marije Niemeijer, Qiuwei Pan, Jan N.M. IJzermans, Luc J.W. van der Laan

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)

Background & Aims: Liver and bile duct diseases often are associated with extensive cell death of cholangiocytes. Necroptosis represents a common mode of programmed cell death in cholangiopathy, however, detailed mechanistic knowledge is limited owin

Externí odkaz: https://doaj.org/article/2f4d610e4e7d4d40a0f49cbdf8749e04

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Akademický článek

Modeling bile duct ischemia and reoxygenation injury in human cholangiocyte organoids for screening of novel cholangio-protective agentsResearch in context

Autor: Shaojun Shi, Henk P. Roest, Thierry P.P. van den Bosch, Marcel J.C. Bijvelds, Markus U. Boehnert, Jeroen de Jonge, Sven O. Dekker, Antoine A.F. de Vries, Hugo R. de Jonge, Monique M.A. Verstegen, Luc J.W. van der Laan

Publikováno v: EBioMedicine, Vol 88, Iss , Pp 104431- (2023)

Summary: Background: Ischemia of the bile duct is a common feature in liver disease and transplantation, which represents a major cause of morbidity and mortality, especially after liver transplantation. Detailed knowledge of its pathogenesis remains

Externí odkaz: https://doaj.org/article/fccca7c2c5564e5b9c23a18e37e160f2

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Akademický článek

Dissecting the multifaceted impact of statin use on fatty liver disease: A multidimensional studyResearch in context

Autor: Ibrahim Ayada, Laurens A. van Kleef, Huai Zhang, Kuan Liu, Pengfei Li, Yasir J. Abozaid, Marla Lavrijsen, Harry L.A. Janssen, Luc J.W. van der Laan, Mohsen Ghanbari, Maikel P. Peppelenbosch, Ming-Hua Zheng, Robert J. de Knegt, Qiuwei Pan

Publikováno v: EBioMedicine, Vol 87, Iss , Pp 104392- (2023)

Summary: Background: Statin use could benefit patients with non-alcoholic fatty liver disease (NAFLD), but the evidence is segmented and inconclusive. This multidimensional study comprehensively investigated the potential benefits and mechanism-of-ac

Externí odkaz: https://doaj.org/article/53dc9352264d4b47883067a90fed6042

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Akademický článek

Characterization of gut-homing molecules in non-endstage livers of patients with primary sclerosing cholangitis and inflammatory bowel disease

Autor: Manon de Krijger, Thijmen Visseren, Manon E. Wildenberg, Gerrit K.J. Hooijer, Monique M.A. Verstegen, Luc J.W. van der Laan, Wouter J. de Jonge, Joanne Verheij, Cyriel Y. Ponsioen

Publikováno v: Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100054- (2020)

Introduction: The co-occurrence of inflammatory bowel disease (IBD) in up to 80% of patients with primary sclerosing cholangitis (PSC) suggests a relation between the gut and the liver in patients with both PSC and IBD. One hypothesis suggests that a

Externí odkaz: https://doaj.org/article/f51490094da7407b8520defb59c6b939

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Akademický článek

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

Publikováno v: Stem Cell Reports, Vol 8, Iss 4, Pp 822-830 (2017)

Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the p

Externí odkaz: https://doaj.org/article/1b75311bbf3843328b88a26d9590e37a

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Akademický článek

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Hepatobiliary tumor organoids for personalized medicine

Autor: Gilles S. van Tienderen, Ling Li, Laura Broutier, Yoshimasa Saito, Patricia Inacio, Meritxell Huch, Florin M. Selaru, Luc J.W. van der Laan, Monique M.A. Verstegen

Publikováno v: Cancer Cell, 40(3), 226-230. Cell Press

Reliable establishment of tumor organoids is paramount to advance applications of organoid technology for personalized medicine. Here, we share our multi-center experience on initiation and tumorigenic confirmation of hepatobiliary cancer organoids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bcd4e7c7be6a2c13b9648ec71a6b72
https://doi.org/10.1016/j.ccell.2022.02.001

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