Zobrazeno 1 - 10
of 250
pro vyhledávání: '"J.W. van der Laan"'
Autor:
M.M. Heldring, B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. Beltman
Publikováno v:
Heliyon, Vol 10, Iss 21, Pp e38406- (2024)
Various groups of chemicals that we encounter in every-day life are known to disrupt the endocrine system, such as estrogen mimics that can disturb normal cellular development and homeostasis. To understand the effect of estrogen on intracellular pro
Externí odkaz:
https://doaj.org/article/8415a89bd51f4a6f806365b1560ad3b9
Autor:
Janna E.G. Roet, Andrew I. Morrison, Aleksandra M. Mikula, Michael de Kok, Daphne Panocha, Henk P. Roest, Luc J.W. van der Laan, Charlotte M. de Winde, Reina E. Mebius
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110179- (2024)
Summary: Fibroblastic reticular cells (FRCs) are mesenchymal stromal cells in human lymph nodes (LNs) playing a pivotal role in adaptive immunity. Several FRC subsets have been identified, yet it remains to be elucidated if their heterogeneity is mai
Externí odkaz:
https://doaj.org/article/7b0ba3c4012342e99af22747b3c9b358
Autor:
Kimberley Ober, Floris J.M. Roos, Gilles S. van Tienderen, Kübra Köten, Annelot Klaassen, Wunan Mi, Luc J.W. van der Laan, Monique M.A. Verstegen
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102431- (2023)
Summary: Bile ducts are essential for bile transport and consist of complex branching tubular networks. Human patient-derived cholangiocyte develops a cystic rather than branching duct morphology. Here, we present a protocol to establish branching mo
Externí odkaz:
https://doaj.org/article/84a4580cad5643e5aaecc2b8f27e89c6
Autor:
Shaojun Shi, Monique M.A. Verstegen, Henk P. Roest, Arif I. Ardisasmita, Wanlu Cao, Floris J.M. Roos, Petra E. de Ruiter, Marije Niemeijer, Qiuwei Pan, Jan N.M. IJzermans, Luc J.W. van der Laan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 541-564 (2022)
Background & Aims: Liver and bile duct diseases often are associated with extensive cell death of cholangiocytes. Necroptosis represents a common mode of programmed cell death in cholangiopathy, however, detailed mechanistic knowledge is limited owin
Externí odkaz:
https://doaj.org/article/2f4d610e4e7d4d40a0f49cbdf8749e04
Autor:
Shaojun Shi, Henk P. Roest, Thierry P.P. van den Bosch, Marcel J.C. Bijvelds, Markus U. Boehnert, Jeroen de Jonge, Sven O. Dekker, Antoine A.F. de Vries, Hugo R. de Jonge, Monique M.A. Verstegen, Luc J.W. van der Laan
Publikováno v:
EBioMedicine, Vol 88, Iss , Pp 104431- (2023)
Summary: Background: Ischemia of the bile duct is a common feature in liver disease and transplantation, which represents a major cause of morbidity and mortality, especially after liver transplantation. Detailed knowledge of its pathogenesis remains
Externí odkaz:
https://doaj.org/article/fccca7c2c5564e5b9c23a18e37e160f2
Autor:
Ibrahim Ayada, Laurens A. van Kleef, Huai Zhang, Kuan Liu, Pengfei Li, Yasir J. Abozaid, Marla Lavrijsen, Harry L.A. Janssen, Luc J.W. van der Laan, Mohsen Ghanbari, Maikel P. Peppelenbosch, Ming-Hua Zheng, Robert J. de Knegt, Qiuwei Pan
Publikováno v:
EBioMedicine, Vol 87, Iss , Pp 104392- (2023)
Summary: Background: Statin use could benefit patients with non-alcoholic fatty liver disease (NAFLD), but the evidence is segmented and inconclusive. This multidimensional study comprehensively investigated the potential benefits and mechanism-of-ac
Externí odkaz:
https://doaj.org/article/53dc9352264d4b47883067a90fed6042
Autor:
Manon de Krijger, Thijmen Visseren, Manon E. Wildenberg, Gerrit K.J. Hooijer, Monique M.A. Verstegen, Luc J.W. van der Laan, Wouter J. de Jonge, Joanne Verheij, Cyriel Y. Ponsioen
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100054- (2020)
Introduction: The co-occurrence of inflammatory bowel disease (IBD) in up to 80% of patients with primary sclerosing cholangitis (PSC) suggests a relation between the gut and the liver in patients with both PSC and IBD. One hypothesis suggests that a
Externí odkaz:
https://doaj.org/article/f51490094da7407b8520defb59c6b939
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 822-830 (2017)
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the p
Externí odkaz:
https://doaj.org/article/1b75311bbf3843328b88a26d9590e37a
Akademický článek
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Autor:
Gilles S. van Tienderen, Ling Li, Laura Broutier, Yoshimasa Saito, Patricia Inacio, Meritxell Huch, Florin M. Selaru, Luc J.W. van der Laan, Monique M.A. Verstegen
Publikováno v:
Cancer Cell, 40(3), 226-230. Cell Press
Reliable establishment of tumor organoids is paramount to advance applications of organoid technology for personalized medicine. Here, we share our multi-center experience on initiation and tumorigenic confirmation of hepatobiliary cancer organoids.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bcd4e7c7be6a2c13b9648ec71a6b72
https://doi.org/10.1016/j.ccell.2022.02.001
https://doi.org/10.1016/j.ccell.2022.02.001