Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension

Autor: Andrew S. Cowburn, Shanhai Xie, David Macías, Alexander J.T. Wood, Stephen Moore, Alexi Crosby, Xinlin Du, Wallace Eli M, Arlette Vassallo, Mark Southwood, Huiling Tan

Publikováno v: The European Respiratory Journal
article-version (VoR) Version of Record

Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role of aberrant hypoxia-induci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32b00f5971d07524076e05a9913a5a2
http://europepmc.org/articles/PMC7930471

C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling

Autor: David K. Menon, Charlotte Summers, Edwin R. Chilvers, Alexander J.T. Wood, Carmelo Zinnato, A. John Simpson, Jonathan Scott, Kamal Kishore, Carmen Gonzalez-Tejedo, Andrew Conway Morris, Clive D'Santos, Klaus Okkenhaug, Marie-Hélène Ruchaud-Sparagano, Arlette Vassallo

Publikováno v: JCI Insight

Critical illness is accompanied by the release of large amounts of the anaphylotoxin, C5a. C5a suppresses antimicrobial functions of neutrophils which is associated with adverse outcomes. The signaling pathways that mediate C5a-induced neutrophil dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b99e14b0f0a845fe0443f1914a1190
http://hdl.handle.net/10044/1/81729

C5a anaphylatoxin and its role in critical illness-induced organ dysfunction

Autor: Alexander J.T. Wood, Charlotte Summers, Edwin R. Chilvers, Andrew Conway-Morris, Arlette Vassallo

Critical illness is an aetiologically and clinically heterogeneous syndrome that is characterised by organ failure and immune dysfunction. Mortality in critically ill patients is driven by inflammation-associated organ damage and a profound vulnerabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e4705ca2f98c56cfab8e534e87ea52
http://hdl.handle.net/10044/1/66498

Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females

Autor: Jason Burton, M. Pedrini, Alexander J.T. Wood, Alexandra Seewann, Barry J. Marshall, William M. Carroll, Kirsten A Bennett, Ian James, Allan G. Kermode

Publikováno v: Pedrini, M J F, Seewann, A, Bennett, K A, Wood, A J T, James, I, Burton, J, Marshall, B J, Carroll, W M & Kermode, A G 2015, ' Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 86, no. 6, pp. 603-607 . https://doi.org/10.1136/jnnp-2014-309495
Journal of Neurology, Neurosurgery and Psychiatry, 86(6), 603-607. BMJ Publishing Group

Background In recent years, a relationship between Helicobacter pylori and many disease conditions has been reported, however, studies in its relationship with multiple sclerosis (MS) have had contradictory results. Objective To determine the associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62dfe098fe09ba7674ae88d45be3c88d
https://research.vumc.nl/en/publications/99e9a03b-10e6-4314-95d0-ecde3ce7c0d6

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