Zobrazeno 1 - 10
of 63
pro vyhledávání: '"J.T. Kuśmierek"'
Publikováno v:
Carcinogenesis. 12:745-747
N2,3-Ethenoguanine (epsilon G) is a product of vinyl chloride reaction with DNA in vivo and of its ultimate metabolite, chloroacetaldehyde, in vitro. The synthesis of the very labile 5'-triphosphate of N2,3-etheno-deoxyguanosine (epsilon dGuo) has ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3af6fe8e6ef84c548d86dd7e370a18
https://doi.org/10.1093/carcin/12.4.745
https://doi.org/10.1093/carcin/12.4.745
Autor:
J.T. Kuśmierek, Peter G. Foiles, Akiyoshi Nishikawa, Brett C. Singer, Lisa M. Miglietta, Fung-Lung Chung
Publikováno v:
Carcinogenesis. 14(1)
Monoclonal antibodies specific for N2,3-ethenodeoxyguanosine (N2,3-epsilon dGuo) and 1,N2-ethenodeoxyguanosine (1,N2-epsilon dGuo) were developed. In a competitive ELISA, 50% inhibition of binding of the N2,3-epsilon dGuo specific antibody (ETH1) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91696fc1dd4cc403175e4c0f414259dc
https://pubmed.ncbi.nlm.nih.gov/8425258
https://pubmed.ncbi.nlm.nih.gov/8425258
Publikováno v:
Biochemistry. 28:1478-1483
The effect of alkyl group size on ability to act as deoxythymidine triphosphate (dTTP) has been studied for the carcinogen products O2-methyl-, O2-ethyl-, and O2-isopropyl-dTTP by using three types of nucleic acids as template and DNA polymerase I (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1764eabdce3324a451ab9f7c16a843b3
https://doi.org/10.1021/bi00430a008
https://doi.org/10.1021/bi00430a008
Autor:
J.T. Kuśmierek, David Shugar
Publikováno v:
Nucleic Acids Research. 5:s73-s78
The key intermediate, O(6)-ethylguanosine, was prepared via diazoethane alkylation of guanosine, and isolated in crystalline form in one step. In the presence of SnCl(2), the compound reacts with diazomethane to give the 2′(3′)-O-methyl-O(6)-ethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18088ca3efbe4397c5910a047abb2c9
https://doi.org/10.1093/nar/1.suppl_1.s73
https://doi.org/10.1093/nar/1.suppl_1.s73
Autor:
Brett C. Singer, J.T. Kuśmierek
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 442:420-431
Several alkylating agents of widely varying reported carcinogenicity (dimethylsulfate, diethylsulfate, ethylmethanesulfonate, methylnitrosourea, ethylnitrosourea and ethylnitrosoguanidine) were reacted with poly(U) at pH values ranging from 4.5 to 7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9782ffe474022b1c54b814351982adb
https://doi.org/10.1016/0005-2787(76)90315-4
https://doi.org/10.1016/0005-2787(76)90315-4
Autor:
J.T. Kuśmierek, B. Singer
Publikováno v:
Nucleic Acids Research. 3:989-1000
In non-aqueous solution, diazomethane and diazoethane react with the O2, O4 and N-3 sites of uridine, thymidine, 1-methyluracil and 1-methylthymine. Diazoethane has a higher affinity for alkylating oxygens than does diazomethane. The relative ratio o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b24b0e1b3d493ecb6b20546530c8b8
https://doi.org/10.1093/nar/3.4.989
https://doi.org/10.1093/nar/3.4.989
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Publikováno v:
Carcinogenesis. 8(5)
N2,3-Ethenoguanine (N2,3-epsilon G) was recently identified in the liver of vinyl chloride-exposed rats. We have now synthesized the nucleoside and the 5'-diphosphate which was copolymerized with CDP. The deoxypolynucleotide complement, synthesized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3cd0ff08baf36d34a4e062b945e65aa
https://pubmed.ncbi.nlm.nih.gov/3581434
https://pubmed.ncbi.nlm.nih.gov/3581434
Publikováno v:
Biochemical and biophysical research communications. 46(4)
Dimethylsulphate treatment of 1-β-D-arabinofuranosylcytosine (ara-C) in aqueous alkaline medium, followed by column chromatography, has led to isolation of all possible O'-methylated derivatives of ara-C. The three mono-methylated derivatives were o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095fe1d582a27ec14bd2fff07599964b
https://pubmed.ncbi.nlm.nih.gov/5015609
https://pubmed.ncbi.nlm.nih.gov/5015609
Publikováno v:
Biochemical and biophysical research communications. 53(2)
2′ (3′)-O-ethyl-CMP was prepared by alkylation of CMP with diethylsulphate in alkaline medium and deaminated to give 2′(3′)-O-ethyl-UMP, which was phosphorylated to 2′(3′)-O-ethyl-UDP. About 90% of the product consisted of the 2′ isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fae059b59ddd5d22246ca3d9125d117
https://pubmed.ncbi.nlm.nih.gov/4716981
https://pubmed.ncbi.nlm.nih.gov/4716981