Zobrazeno 1 - 10 of 171 pro vyhledávání: '"J.R.S. Hoult"'
1
The effects of heparin and related molecules upon the adhesion of human polymorphonuclear leucocytes to vascular endotheliumin vitro
Autor: Rebecca Lever, Clive P. Page, J.R.S. Hoult
Publikováno v: British Journal of Pharmacology. 129:533-540
1. The effects of an unfractionated heparin preparation (Multiparin), a low molecular weight heparin preparation (Fragmin) and a selectively O-desulphated derivative of heparin lacking anticoagulant activity, have been investigated for their effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f08d3ab937f6792a62d88e4e9bf75b67
https://doi.org/10.1038/sj.bjp.0703099
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2
The in vitro effects of 6-methoxy-2-naphthylacetic acid, the active metabolite of nabumetone, on rat gastric mucosal eicosanoid synthesis and metabolism
Autor: R. Melarange, R. Spangler, J.R.S. Hoult
Publikováno v: Prostaglandins, Leukotrienes and Essential Fatty Acids. 55:195-200
Nabumetone is a neutral non-steroidal anti-inflammatory drug with a low propensity to cause gastrointestinal (GI) damage. Previous studies, in vivo, have shown that the drug has weak effects on gastric mucosal cyclooxygenase activity, which may help
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ba510127b2580c4f3ebf045810c547
https://doi.org/10.1016/s0952-3278(96)90098-8
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3
Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive α-methylenebutyrolactone functions
Autor: J.R.S. Hoult, Kurt Hostettmann, Matthias Hamburger, Alastair J.B. Hay
Publikováno v: British Journal of Pharmacology. 112:9-12
1. Previous studies have shown that extracts of feverfew (Tanacetum parthenium) and parthenolide, a sesquiterpene alpha-methylenebutyrolactone obtained from it, inhibit smooth muscle contractility in a time-dependent, non-specific and irreversible ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f36b89a6254a5e726483dd4526ed7
https://doi.org/10.1111/j.1476-5381.1994.tb13020.x
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4
Eicosanoid synthesis and Helicobacter pylori associated gastritis: increase in leukotriene C4 generation associated with H. pylori colonization
Autor: A. Ahmed, J. Holton, D. Vaira, J.R.S. Hoult, S.K. Smith
Publikováno v: Prostaglandins. 44(1)
The importance of pro-inflammatory leukotriene C4 in Helicobacter pylori (H. pylori) associated gastritis in man is unknown. Fresh gastric biopsy specimens from 28 dyspeptic patients were obtained: 10 showed normal antral histology with no evidence o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2bf9c9e3f8e39628eabd1ce04bf1f2
https://pubmed.ncbi.nlm.nih.gov/1641505
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5
Differential regulation of 5-lipoxygenase and cyclo-oxygenase pathways of arachidonate metabolism in rat peritoneal leukocytes
Autor: F. Carey, R. A. Forder, M.A. Moroney, J.R.S. Hoult
Publikováno v: British journal of pharmacology. 101(1)
1. Simultaneous activation of the 5-lipoxygenase and cyclo-oxygenase pathways of arachidonate metabolism in rat peritoneal mixed leukocytes in response to A23187, chemoattractant N-formyl-methionine-leucine-phenylalanine (FMLP) and arachidonic acid (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64fbfd56472433215992991d6aa2c9f
https://pubmed.ncbi.nlm.nih.gov/2178012
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6
Inhibition of prostaglandin 15-hydroxydehydrogenase by sulphasalazine and a novel series of potent analogues
Autor: S.H. Peers, J.R.S. Hoult, H. Agback, C.N. Berry
Publikováno v: Biochemical Pharmacology. 32:2863-2871
The ability of sulphasalazine, its colonic metabolites and various analogues to inhibit prostaglandin inactivation by two purified preparations of type INAD+-dependent prostaglandin 15-hydroxydehydrogenase or in various 100,000 g cytosolic supernatan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba773b1c84a663745ef48bafc4320fa
https://doi.org/10.1016/0006-2952(83)90390-8
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7
Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors
Autor: Sussan Nourshargh, J.R.S. Hoult
Publikováno v: European Journal of Pharmacology. 122:205-212
The secretory response of cytochalasin B-treated human polymorphonuclear neutrophils to the peptide chemoattractant f-Met-Leu-Phe (FMLP), the calcium ionophore A23187 and other secretagogues was measured by assaying neutrophil supernatants for the gr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b33e9dd8fd3ec946053da307ce482bb
https://doi.org/10.1016/0014-2999(86)90104-4
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9
Divergent effects of co-carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion
Autor: Sussan Nourshargh, J.R.S. Hoult
Publikováno v: British Journal of Pharmacology. 91:557-568
The effects of two co-carcinogenic phorbol esters (phorbol myristate acetate (PMA) and phorbol dibutyrate (PDBu] and a synthetic diacylglycerol (OAG, 1-oleoyl-2-acetyl-glycerol), which all stimulate protein kinase C, were compared with two inactive p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cda5b88de2e85603133f5b223f16515
https://doi.org/10.1111/j.1476-5381.1987.tb11249.x
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