Blocking Dopamine D2 Receptors by Haloperidol Curtails the Beneficial Impact of Calorie Restriction on the Metabolic Phenotype of High-Fat Diet Induced Obese Mice

Autor: J.P. Schröder-van der Elst, E. T. Parlevliet, H. E. Auvinen, C. P. Coomans, Onno C. Meijer, Hanno Pijl, J. E. de Leeuw van Weenen

Publikováno v: Journal of Neuroendocrinology. 23:158-167

Calorie restriction is the most effective way of expanding life-span and decreasing morbidity. It improves insulin sensitivity and delays the age-related loss of dopamine receptor D(2) (DRD2) expression in the brain. Conversely, high-fat feeding is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b347a6bf9d3aa8c081a9ad00cd4e676
https://doi.org/10.1111/j.1365-2826.2010.02092.x

Different Tissue Distribution, Elimination, and Kinetics of Thyroxine and Its Conformational Analog, the Synthetic Flavonoid EMD 49209 in the Rat1

Autor: J.P. Schröder-van der Elst, H. Rokos, Josef Köhrle, G. Morreale de Escobar, D. van der Heide

Publikováno v: Endocrinology. 138:79-84

The synthetic flavonoids EMD 23188 and EMD 49209, developed as T4 analogs, displace T4 from transthyretin, and in vitro they inhibit 5′-deiodinase activity. In vivo EMD 21388 causes tissue-specific changes in thyroid hormone metabolism. In tissues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cb6e88a87ac98c14245df5d256dd080
https://doi.org/10.1210/endo.138.1.4848

Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice

Autor: Edwin T. Parlevliet, K. Willems van Dijk, Hanno Pijl, J. E. de Leeuw van Weenen, Johannes A. Romijn, S.A.A. van den Berg, J.P. Schröder-van der Elst

Publikováno v: Experimental Diabetes Research
Experimental Diabetes Research, Vol 2011 (2011)

High fat feeding induces a variety of obese and lean phenotypes in inbred rodents. Compared to Diet Resistant (DR) rodents, Diet Induced Obese (DIO) rodents are insulin resistant and have a reduced dopamine receptor D2 (DRD2) mediated tone. We hypoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53121b8248fcc20f87535ec5d44ee2e
https://pubmed.ncbi.nlm.nih.gov/21603181

Thyroxine, 3,5,3'-Triiodothyronine, and 3,3',5-Triiodothyronine Concentrations in Several Tissues of the Rat: Effects of Amiodarone and Desethylamiodarone on Thyroid Hormone Metabolism

Autor: J.P. Schröder-van der Elst, D. van der Heide

Publikováno v: Endocrinology. 127:1656-1664

The effects of amiodarone, an iodinated antiarrhythmic drug, on thyroid hormone metabolism are known. It is not known whether the main metabolite, desethylamiodarone, is responsible. We investigated the influence of both compounds on the intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3c67d6a51e6981fe258f9214da024d
https://doi.org/10.1210/endo-127-4-1656

Differential effects of natural flavonoids on growth and iodide content in a human NA+/I_symporter-transfecred follicular thyroid carcinoma cell line

Autor: Johannes A. Romijn, J.P. Schröder-van der Elst, D. van der Heide, Jan W. A. Smit

Publikováno v: European Journal of Endocrinology 150 (2004) 4
European Journal of Endocrinology, 150(4), 557-564
European journal of endocrinology / European Federation of Endocrine Societies, 150(4), 557-564. BioScientifica Ltd.

OBJECTIVE: Natural flavonoids (plant pigments) have been shown to inhibit thyroid peroxidase (TPO) in vitro and the growth of thyroid cancer cell lines. We have studied the role of flavonoids on the iodide transport and the growth of the human follic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e86dcd1e7e8c63cff56e1dc277f81d
https://research.wur.nl/en/publications/differential-effects-of-natural-flavonoids-on-growth-and-iodide-c