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Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye

Autor: J.P. Gergen, Ling-Hui Li

Publikováno v: Development. 126:3313-3322

Brother and Big brother were isolated as Runt-interacting proteins and are homologous to CBF β, which interacts with the mammalian CBF α Runt-domain proteins. In vitro experiments indicate that Brother family proteins regulate the DNA binding activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc09b7103ff32ec9c8e7090319917a3
https://doi.org/10.1242/dev.126.15.3313

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Direct activation of Sex-lethal transcription by the Drosophila Runt protein

Autor: S.G. Kramer, T.M. Jinks, P. Schedl, J.P. Gergen

Publikováno v: Development. 126:191-200

Runt functions as a transcriptional regulator in multiple developmental pathways in Drosophila melanogaster. Recent evidence indicates that Runt represses the transcription of several downstream target genes in the segmentation pathway. Here we demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378edc4a90296a029aec92746b2895a9
https://doi.org/10.1242/dev.126.1.191

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A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood

Autor: Gerald H. Thomsen, W.D. Tracey, J.P. Gergen, Melissa E. Pepling, Marko E. Horb

Publikováno v: Development. 125:1371-1380

The Runt domain gene AML1 is essential for definitive hematopoiesis during murine embryogenesis. We have isolated Xaml, a Xenopus AML1 homologue in order to investigate the patterning mechanisms responsible for the generation of hematopoietic precurs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd08822f1da4b8505df95e6cde816f3
https://doi.org/10.1242/dev.125.8.1371

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Mutations that perturb poly(A)-dependent maternal mRNA activation block the initiation of development

Autor: M.E. Lieberfarb, J.P. Gergen, Christopher Wreden, William E. Theurkauf, Sidney Strickland, Tehyen Chu

Publikováno v: Europe PubMed Central

Translational recruitment of maternal mRNAs is an essential process in early metazoan development. To identify genes required for this regulatory pathway, we have examined a collection of Drosophila female-sterile mutants for defects in translation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5955c3d1484ca687256dd1c8de122c3b
https://doi.org/10.1242/dev.122.2.579

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Expression and function of the Drosophila gene runt in early stages of neural development

Autor: M.A. Kania, J.B. Duffy, J.P. Gergen

Publikováno v: Development. 113:1223-1230

The Drosophila gene runt was initially identified on the basis of its role during segmentation. Recent molecular and genetic studies have demonstrated that the runt gene encodes a novel nuclear protein whose developmental importance is not exclusive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953d1d58a4d91263f76dddb420dc7d44
https://doi.org/10.1242/dev.113.4.1223

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Conservation and function of the transcriptional regulatory protein Runt

Autor: J.P. Gergen, Melissa E. Pepling

A phylogenetic approach was used to identify conserved regions of the transcriptional regulator Runt. Alignment of the deduced protein sequences from Drosophila melanogaster, Drosophila pseudoobscura, and Drosophila virilis revealed eight blocks of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cf92bd136540a5840d2f38f4b4a01a
https://europepmc.org/articles/PMC40929/

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Gap gene properties of the pair-rule gene runt during Drosophila segmentation

Autor: Chihcheng Tsai, J.P. Gergen

Publikováno v: Development (Cambridge, England). 120(6)

The Drosophila Runt protein is a member of a new family of transcriptional regulators that have important roles in processes extending from pattern formation in insect embryos to leukemogenesis in humans. We used ectopic expression to investigate run

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a075c2ff4068f46cc05241cc3fd9ccbd
https://pubmed.ncbi.nlm.nih.gov/8050373

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The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

Autor: J.P. Gergen, J.B. Duffy, A S Bonner, M A Kania

Publikováno v: Genesdevelopment. 4(10)

Generation of the anterior-posterior body pattern in the Drosophila embryo requires the activity of the segmentation genes. The segmentation gene runt has been classified as one of the primary pair-rule genes because of the pivotal role it plays in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adb12b1f1ce19df96b5f3d90a15873f
https://pubmed.ncbi.nlm.nih.gov/2249771

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Akademický článek

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