Zobrazeno 1 - 10
of 78
pro vyhledávání: '"J.P. Devissaguet"'
Autor:
Gillian Barratt, Francis Puisieux, J.P. Devissaguet, Hatem Fessi, Silvia Stanisçuaski Guterres
Publikováno v:
Journal of Biomaterials Science, Polymer Edition. 11:1347-1355
The aim of this work was to determine whether encapsulation of a non steroidal antiinflammatory agent within nanocapsules could reduce local toxicity after intramuscular injection. Diclofenac-loaded nanocapsules were prepared by deposition of poly(ra
Publikováno v:
Journal of Biomaterials Science, Polymer Edition. 10:47-62
Nanoparticles have been obtained directly in aqueous media, from amphiphilic copolymers synthesized by radical polymerization of methyl methacrylate (MMA) initiated by Ce(IV) ions in the presence of heparin or dextran. The reaction conditions under w
Publikováno v:
International Journal of Pharmaceutics. 146:233-238
The importance of the nature of two solvents used in a patented method for obtaining aqueous dispersions of polymers is discussed. The principle of the method resides in the fact that a preformed polymer can precipitate as nanospheres when a solution
Autor:
E. S. Tabosa Do Egito, Gillian Barratt, Philippe Legrand, Hatem Fessi, M. Appel, J.P. Devissaguet, J. Bolard
Publikováno v:
International Journal of Pharmaceutics. 145:17-27
The structure of an amphotericin B emulsion-based delivery system (AmB-E) was investigated using spectroscopic methods (electronic absorption and circular dichroism (CD)), photon correlation spectroscopy (PCS) and transmission electron microscopy (TE
Publikováno v:
International Journal of Pharmaceutics. 139:113-123
Polyester nanoparticles have shown promising results in the ophthalmic area for optimization of the bioavailability of drugs. However, polyesters can undergo hydrolysis during storage in aqueous media and their degradation can be enhanced by micro-or
Publikováno v:
International Journal of Pharmaceutics. 133:107-115
Indomethacin loaded poly(D,L-lactide) nanocapsules (PLA-NCs) were investigated after intravenous and rectal administration to rabbits. A rebound of indomethacin plasma concentrations attributed to enterohepatic circulation of indomethacin was observe
Publikováno v:
Drug Development and Industrial Pharmacy. 21:229-241
An original process for obtaining colloidal dispersions were used to prepare pseudolatex of coating polymers (Eudragit E 100 and Eudragit S 100). The method consists in introducing under magnetic stirring a solution of the polymers in a water-miscibl
Autor:
Francis Puisieux, J.P. Devissaguet, Silvia Stanisçuaski Guterres, Gillian Barratt, Hatem Fessi
Publikováno v:
International Journal of Pharmaceutics. 113:57-63
The aim of this work was to formulate nanocapsules prepared from poly(DL-lactide) containing a non-steroidal anti-infammatory drug, diclofenac, and to study their stability during storage at room temperature. The influence of some factors wich could
Publikováno v:
Journal of Controlled Release. 33:107-113
We investigated the possible use of a local chemotherapy in the treatment of malignant lesions in bone. Therefore, the diffusion of cisplatin from polymethyl methacrylate implants was studied in vitro and in vivo in rabbits. Cisplatin-loaded implants
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1224:427-432
Treatment with muramyldipeptide (MDP) or a lipophilic derivative (MTP-Chol) included in nanocapsules renders macrophages cytostatic towards tumor cells. At the same time, nitric oxide (NO) synthase (EC 1.14.23) activity is induced, as determined by m