P-250 A shared gene expression signature in human blastocyst embryos affected by a mitochondrial disorder

Autor: K Chatzovoulou, A Mayeur, N Cagnard, Z Mohammed, C Bole, P Nitschke, F Jabot-Hanin, A Rötig, S Monnot, J.P Bonnefont, A Munnich, N Achour, J Steffann

Publikováno v: Human Reproduction. 37

Study question Do human blastocyst embryos affected by mitochondrial disorders have gene expression disruption? Summary answer A global transcriptional repression was found in embryos carrying mutations in mitochondrial genes, primarily affecting oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef6616a2f5546537cdcabebe67f05f01
https://doi.org/10.1093/humrep/deac107.240

Clinical approach to inherited metabolic disorders in neonates

Autor: J.M. Saudubray, C. Narcy, L. Lyonnet, J.P. Bonnefont, B.T. Poll The, A. Munnich

Publikováno v: Biology of the neonate, 58(Suppl. 1), 44-53. S. Karger AG
Europe PubMed Central

Most inborn errors of intermediary metabolism presenting in the neonatal period fall schematically into three clinical categories: (1) those which lead to a neurological distress ‘intoxication type’ with a symptom-free interval, vomiting, comas,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdad415160069b2445c1475586b18a3
https://pubmed.ncbi.nlm.nih.gov/2265219

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TENT5A mediates the cancer-inhibiting effects of EGR1 by suppressing the protein stability of RPL35 in hepatocellular carcinoma.

Autor: Min X; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Lin F; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Zhao X; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Yu J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Ge C; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Zhang S; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Li X; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Zhao F; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Chen T; Department of Pathology, Qi Dong Liver Cancer Institute, Qidong, 226220, China., Tian H; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China., Yan M; Department of Animal Experimental Center, Fudan University Shanghai Cancer Center, Shanghai, 201102, China., Li J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China. jjli@shsci.org., Li H; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 25/Ln 2200 Xietu Road, Shanghai, 200032, China. hongli@shsci.org.

Publikováno v: Cellular oncology (Dordrecht, Netherlands) [Cell Oncol (Dordr)] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.