Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J.O. Buchanan"'
Autor:
Marianne E. Federici, Nicholas A. Meanwell, C.L. Brassard, George B. Zavoico, J.O. Buchanan, Steven M. Seiler, J. Stuart Fleming
Publikováno v:
Thrombosis Research. 74:115-123
BMY 42393, (2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid), is a new prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC 50 range 0.3 - 2.0 μM). BMY 42393 stimulated platelet adenylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092a8cbafefe9a6cc0406da3211e77a9
https://doi.org/10.1016/0049-3848(94)90004-3
https://doi.org/10.1016/0049-3848(94)90004-3
Autor:
Michael J. Rosenfeld, J.O. Buchanan, C.L. Brassard, Wright John J, Jeffrey L. Romine, Scott W. Martin, M F Malley, Nicholas A. Meanwell, J Z Gougoutas, Ashok K. Trehan
Publikováno v:
Journal of Medicinal Chemistry. 36:3884-3903
cis-[3-[2-(4,5-Diphenyl-2-oxazolyl)ethenyl]phenoxy]acetic acid (3) was previously identified as a nonprostanoid prostacyclin (PGI2) mimetic that potently inhibits ADP-induced aggregation of human platelets with an IC50 of 0.18 microM. As part of an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158ee0ac0b49f4bd2a364b061a4b45ce
https://doi.org/10.1021/jm00076a018
https://doi.org/10.1021/jm00076a018
Autor:
Marianne E. Federici, Karen S. Hartl, M. J. Rosenfeld, Nicholas A. Meanwell, S. M. Seiler, M. Gamberdella, C.L. Brassard, George B. Zavoico, Wright John J, J.O. Buchanan, J. S. Fleming
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5750623e706a9d468fac7a16f0d54df8
https://doi.org/10.1002/chin.199425128
https://doi.org/10.1002/chin.199425128
Autor:
Wright John J, H. R. Roth, Dennis Rd, Michael J. Rosenfeld, E. Gillespie, J.O. Buchanan, C.L. Brassard, Nicholas A. Meanwell, M. Gamberdella, E. C. R. Smith
Publikováno v:
Journal of Medicinal Chemistry. 35:2688-2696
Two series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives incorporating an additional site for acid salt formation were synthesized and evaluated as inhibitors of human blood platelet cAMP phosphodiesterase (PDE) and ADP-induced platelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2550f423e3c3ddc4e37e6500ba9dedb6
https://doi.org/10.1021/jm00092a020
https://doi.org/10.1021/jm00092a020
Autor:
Nicholas A. Meanwell, Michael J. Rosenfeld, J. Stuart Fleming, Marianne E. Federici, J.O. Buchanan, J. J. Kim Wright, C.L. Brassard, Steven M. Seiler
Publikováno v:
Journal of Medicinal Chemistry. 35:389-397
A series of phenylated pyrazoloalkanoic acid derivatives were synthesized and evaluated as inhibitors of ADP-induced human platelet aggregation. 3,4,5-Triphenyl-1H-pyrazole-1-nonanoic acid (8d), with an IC50 of 0.4 microM, was the most potent inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8237658f59beded84c5081d742e3d743
https://doi.org/10.1021/jm00080a028
https://doi.org/10.1021/jm00080a028
Publikováno v:
Thrombosis Research. 63:145-155
BMY-43351 is a new broad-spectrum inhibitor of platelet aggregation with greater aqueous solubility than earlier analogs from the imidazoquinoline series. This report compares the antithrombotic activity of BMY-43351 to that of two other imidazoquino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9730ade752579fc3a61e724e1987ff1
https://doi.org/10.1016/0049-3848(91)90277-4
https://doi.org/10.1016/0049-3848(91)90277-4
Autor:
J.O. Buchanan, William A. Schumacher, J. Stuart Fleming, M. Gamberdella, Steven M. Seiler, George B. Zavoico, Nicholas A. Meanwell
Publikováno v:
Thrombosis research. 74(2)
The oral activity and antithrombotic efficacy of BMY 42393 was examined in ex vivo platelet aggregation studies and arterial thrombosis animal models. In a heterologous ex vivo platelet aggregation assay, ADP-induced human platelet aggregation was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be7f92e0ab8c8ddb8d57f72e3e13bbd
https://pubmed.ncbi.nlm.nih.gov/8029813
https://pubmed.ncbi.nlm.nih.gov/8029813
Autor:
Marianne E. Federici, C.L. Brassard, Michael J. Rosenfeld, Karen S. Hartl, Nicholas A. Meanwell, M. Gamberdella, J.O. Buchanan, George B. Zavoico, J. S. Fleming, Wright John J
Publikováno v:
Journal of medicinal chemistry. 36(24)
The 4,5-diphenyloxazole derivatives 2-4 were previously identified as nonprostanoid prostacyclin (PGI2) mimetics. A series of derivatives of 2-4 bearing substitutents at the carbon atom alpha to the oxazole ring were synthesized and evaluated as inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b7b3345587a90002dca0bc61ffc844
https://pubmed.ncbi.nlm.nih.gov/8254619
https://pubmed.ncbi.nlm.nih.gov/8254619
Autor:
J. Stuart Fleming, Jeffrey L. Romine, J.O. Buchanan, George B. Zavoico, Ashok K. Trehan, Steven M. Seiler, Michael J. Rosenfeld, C.L. Brassard, Marianne E. Federici, J. J. Kim Wright, Nicholas A. Meanwell, M. Gamberdella
Publikováno v:
Journal of medicinal chemistry. 35(19)
4,5-Diphenyl-2-oxazolenonanoic acid (2) and 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (3) were previously identified as nonprostanoid prostacyclin (PGI2) mimetics that inhibit ADP-induced aggregation of human platelets in vitro. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f9213e4ee7c0cd1de77eb4fabca0d9
https://pubmed.ncbi.nlm.nih.gov/1404231
https://pubmed.ncbi.nlm.nih.gov/1404231
Autor:
E. Gillespie, D. L. Wedding, E. C. R. Smith, M. Gamberdella, Nicholas A. Meanwell, Bradley C. Pearce, J.O. Buchanan, U.M. Baryla, H. R. Roth, Wright John J
Publikováno v:
Journal of medicinal chemistry. 35(14)
A series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives, substituted at the 7-position with functionalized side chains, was synthesized and evaluated as inhibitors of human blood platelet cAMP phosphodiesterase (PDE) as well as ADP- and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bde35e6ad9081fee2e9ec4b69bb40af
https://pubmed.ncbi.nlm.nih.gov/1321910
https://pubmed.ncbi.nlm.nih.gov/1321910