Zobrazeno 1 - 10
of 84
pro vyhledávání: '"J.N. Champness"'
Autor:
J.N. Champness, Janice M Garvey, Lee F. Kuyper, Christopher R Beddell, David P. Baccanari, David K. Stammers
Conformationally restricted analogues of the antibacterial agent trimethoprim (TMP) were designed to mimic the conformation of drug observed in its complex with bacterial dihydrofolate reductase (DHFR). This conformation of TMP was achieved by linkin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126edf956a8b4405069d2a3c1c0b3460
https://ora.ox.ac.uk/objects/uuid:d3b2050e-70c1-4f03-8cd4-50611776f0af
https://ora.ox.ac.uk/objects/uuid:d3b2050e-70c1-4f03-8cd4-50611776f0af
Autor:
David K. Stammers, Anthony C.T. North, C. R. Beddell, D. Ogg, Elias Eliopoulos, J.N. Champness, A.J. Geddes, J.G. Dann
The structure of mouse L1210 dihydrofolate reductase (DHFR) complexed with NADPH and trimethoprim has been refined at 2.0 Å resolution. The analogous complex with NADPH and methotrexate has been refined at 2.5 Å resolution. These structures reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575a083bd3bd04e0023f31bf2835e5c9
https://ora.ox.ac.uk/objects/uuid:b55acfb9-a49d-4914-a21d-eaba9309d917
https://ora.ox.ac.uk/objects/uuid:b55acfb9-a49d-4914-a21d-eaba9309d917
Autor:
J.N. Champness, David I. Stuart, S.P. Ballantine, C.J. Delves, David K. Stammers, E Y Jones, A Achari, P.K. Bryant
Dihydrofolate reductase from Pneumocytis carinii has been crystallized in a form suitable for high resolution X-ray diffraction studies. Recombinant enzyme that had been refolded following solubilization in guanidinium hydrochloride was crystallized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf64e09978e5a32b1eafa8307b8a82e
https://ora.ox.ac.uk/objects/uuid:919a6baf-fb4d-4bb9-9fad-2d8342515713
https://ora.ox.ac.uk/objects/uuid:919a6baf-fb4d-4bb9-9fad-2d8342515713
Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to the synthesis of clinically useful analogues. Today sulfametho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb5ca4005a12bd847ed25ee48a3d51f
https://doi.org/10.1038/nsb0697-490
https://doi.org/10.1038/nsb0697-490
Autor:
J.N. Champness, David K. Stammers, C.J. Delves, S.P. Ballantine, P.K. Bryant, Aniruddha Achari
Background: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ac09d15a02a27f282e578ff75f3779
https://ora.ox.ac.uk/objects/uuid:3be2c6ab-e5ba-43b6-b40d-a783c76f0afc
https://ora.ox.ac.uk/objects/uuid:3be2c6ab-e5ba-43b6-b40d-a783c76f0afc
Autor:
Matthew S. Bennett, J. Rozenski, Piet Herdewijn, and Mark R. Sanderson, Tomasz Ostrowski, Berthold Wroblowski, Erik De Clercq, William C. Summers, J.N. Champness, Roger Busson
Publikováno v:
Journal of Medicinal Chemistry. 41:4343-4353
A new series of anhydrohexitol nucleosides are described. These compounds have a pyrimidine base moiety substituted in the 5-position with a chloro (1b), trifluoromethyl (1c), vinyl (1d), 2-thienyl (1e), ethynyl (1f) or propynyl (1g) substituent. The
Autor:
Alexander Buchan, Philippa Mcleish, Mark R. Sanderson, Barry A. Levine, J.N. Champness, James S. Evans, William C. Summers, Kevin Lock
Publikováno v:
Journal of General Virology. 79:2083-2092
Autor:
J.N. Champness, Richard L. Jarvest, William C. Summers, Piet Herdewijn, Erik De Clercq, Mark R. Sanderson, Rob Visse, Matthew S. Bennett, Frank Wien, Tomasz Ostrowski
Publikováno v:
Proteins: Structure, Function, and Genetics. 32:350-361
Antiherpes therapies are principally targeted at viral thymidine kinases and utilize nucleoside analogs, the triphosphates of which are inhibitors of viral DNA polymerase or result in toxic effects when incorporated into DNA. The most frequently used
Autor:
Mark R. Sanderson, Juan C. Fontecilla-Camps, Geri F. Moolenaar, J.N. Champness, X. Vernede, M.K. Sohi, Alexander Alexandrovich, Nora Goosen, R. Visse
Publikováno v:
FEBS letters. 465(2-3)
A crystal structure of the C-terminal domain of Escherichia coli UvrB (UvrB′) has been solved to 3.0 Å resolution. The domain adopts a helix-loop-helix fold which is stabilised by the packing of hydrophobic side-chains between helices. From the Uv
Autor:
David L. Scott, D. O. Somers, J. Rosemond, David K. Stammers, P.K. Bryant, Aniruddha Achari, J.N. Champness
Publikováno v:
FEBS letters. 456(1)
The X-ray crystal structure of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase (PPPK) in a ternary complex with ATP and a pterin analogue has been solved to 2.0 A resolution, giving, for the first time, detailed information of the PPPK/ATP intermo