Výsledky vyhledávání - "J.M.A. van Gerven"

Cannabidiol in anxiety research: a translational integration of preclinical and clinical studies

Autor: C. Kwee, L. Groenink, N.A. Leen, J.M.A. van Gerven, D.C. Cath, J.M.P. Baas

Publikováno v: Neuroscience Applied. 1(S2)

Introduction: Preclinical research suggests that cannabidiol (CBD) may have therapeutic potential in pathological anxiety. Guidelines to inform the study design of future human studies are however lacking. Aims: We aimed to determine the boundary con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d00fdfb4d79a6087a147ae2d434fd43
https://doi.org/10.1016/j.nsa.2022.100743

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341 Acute effects of seltorexant, a selective orexin-2 antagonist (JNJ- 42847922), on driving after bedtime administration

Autor: P. Van der Ark, Gabriel E. Jacobs, I. Kezic, J.M.A. van Gerven, Sander Brooks, A Savitz, Rob Zuiker

Publikováno v: Sleep. 44:A136-A136

Introduction Seltorexant (JNJ-42847922), a potent and selective antagonist of the human orexin-2 receptor, is being developed for the treatment of major depressive disorder. Seltorexant also has sleep-promoting properties. Investigating the effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1a13f8e246b16592c5a84ce03d55bdf
https://doi.org/10.1093/sleep/zsab072.340

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The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol

Publikováno v: Journal of Psychopharmacology, 26, 2, pp. 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302

Item does not contain fulltext Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1fbad04db88a008450901c8347b622
https://hdl.handle.net/2066/109808

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Desmopressin as a pharmacological tool in vasopressinergic hypothalamus-pituitary-adrenal axis modulation: Neuroendocrine, cardiovascular and coagulatory effects

Autor: J. Burggraaf, E.G.J. Hulskotte, J.M.A. van Gerven, Pierre A.M. Peeters, J Elassaiss-Schaap, Lineke Zuurman, ML de Kam, Gé S.F. Ruigt, J. van Pelt, Bernard W. M. M. Peeters, Gabriel E. Jacobs

Publikováno v: Journal of Psychopharmacology, 25, 353-60
Journal of Psychopharmacology, 25(3), 353-360
Journal of Psychopharmacology, 25, 3, pp. 353-60

Arginine-vasopressin (AVP) is a physiological co-activator of the hypothalamus–pituitary–adrenal (HPA) axis, together with corticotrophin releasing hormone (CRH). A synthetic analogue of AVP, desmopressin (dDAVP), is often used as a pharmacologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974bef2b4785db0ba8c82ddf6cdafab7
https://doi.org/10.1177/0269881109358203

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Metoclopramide as pharmacological tool to assess vasopressinergic co-activation of the hypothalamus–pituitary–adrenal (HPA) axis: A study in healthy volunteers

Autor: G. Zha, Gabriel E. Jacobs, P. Hu, J. Jiang, J. van Pelt, ML de Kam, J.M.A. van Gerven, Jaap G. Goekoop, Frans G. Zitman, Q. Zhao, E.G.J. Hulskotte

Publikováno v: European Neuropsychopharmacology, 20(12), 866-874

The synthetic vasopressin (AVP) analogue desmopressin (dDAVP) has been used as pharmacological function test to quantify vasopressinergic co-activation of the hypothalamus pituitary adrenal (HPA) axis in the past. Such exogenous vasopressinergic stim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b9d34f016aad0f5e8b12df79fcd233
https://doi.org/10.1016/j.euroneuro.2010.06.009

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Method development studies for repeatedly measuring anxiolytic drug effects in healthy humans

Autor: F. Roesch, Eric Prinssen, Johanna M.P. Baas, J.L. Kenemans, I. Niklson, Floris Klumpers, Wim J. Riedel, J.M.A. van Gerven

Publikováno v: Journal of Psychopharmacology, 24(5), 657-666. SAGE Publications Ltd

Human experimental models for anxiety may serve as translational tools for translating preclinical psychopharmacological investigations into human studies. For the evaluation of drugs of which pharmacokinetics and pharmacodynamics are unidentified, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506a59f5f8ae3394ecf9be92df5fce92
https://cris.maastrichtuniversity.nl/en/publications/8eea3b13-dd20-43d2-a7bf-ed44de595dac

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