Pathophysiology of multiple sclerosis: a controversial new perspective

Autor: J.M. van Noort, Sandra Amor

Publikováno v: van Noort, J M & Amor, S 2013, Pathophysiology of multiple sclerosis: a controversial new perspective . in Personalized Management of Multiple Sclerosis . pp. 22-34 . https://doi.org/10.2217/ebo.12.277
Personalized Management of Multiple Sclerosis, 22-34
STARTPAGE=22;ENDPAGE=34;TITLE=Personalized Management of Multiple Sclerosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1d61912c0f4a70d5f326e3adef55c1
https://doi.org/10.2217/ebo.12.277

Isolation and characterization of mutants of Aspergillus niger deficient in extracellular proteases

Autor: C.A.M.J.J. van den Hondel, I. E. Mattern, J.M. van Noort, I. N. Roberts, P. van den Berg, David B. Archer

Publikováno v: Molecular and General Genetics MGG. 234:332-336

In the present study, the extracellular protease activity in a strain of the filamentous fungus Aspergillus niger was investigated and mutant strains deficient in the production of extracellular proteases were isolated. The major protease, which is r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbb70eede6e1b58c37f56b06f10109a
https://doi.org/10.1007/bf00283855

Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE

Autor: H.E. de Vries, E.E.J. Geisert, Gijs Kooij, S.M.A. van der Pol, S. Dijkstra, J.M. van Noort, Christine D. Dijkstra, Sandra Amor, R. Verbeek

Publikováno v: Dijkstra, S, Kooij, G, Verbeek, R, van der Pol, S M A, Amor, S, Geisert, E E J, Dijkstra, C D, van Noort, J M & de Vries, H E 2008, ' Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE ', Neurobiology of Disease, vol. 31, no. 3, pp. 413-421 . https://doi.org/10.1016/j.nbd.2008.05.018
Neurobiology of Disease, 31(3), 413-421. Academic Press Inc.
Neurobiology of Disease, 3, 31, 413-421
Neurobiology of Disease, Vol 31, Iss 3, Pp 413-421 (2008)

Leukocyte infiltration is a key step in the development of demyelinating lesions in multiple sclerosis (MS), and molecules mediating leukocyte-endothelial interactions represent prime candidates for the development of therapeutic strategies. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1e451897b5a490aba65c977084b464
https://research.vumc.nl/en/publications/131f59d1-0a5e-4120-987b-1f7504268f65

Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire

Autor: J F Meilof, Chris H. Polman, R. Verbeek, J.M. van Noort, Sandra Amor

Publikováno v: van Noort, J M, Verbeek, R, Meilof, J F, Polman, C H & Amor, S 2006, ' Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire ', Multiple Sclerosis, vol. 12, no. 3, pp. 287-93 . https://doi.org/10.1191/135248506ms1271oa
Multiple Sclerosis, 12(3), 287-93. SAGE Publications Ltd
Multiple Sclerosis, 3, 12, 287-293

Human T-cell responses to the stress protein alpha B-crystallin in multiple sclerosis (MS)-affected brain samples are dominant when compared to other myelin antigens. The establishment of the apparent autoimmune repertoire against this antigen has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333376dbb060d7d6390802deeeace19b
https://research.vumc.nl/en/publications/6283053b-32bb-4d2a-9a0f-7ca96c8acc94

Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: an early event following inflammatory demyelination

Autor: C. Koevoets, M L Cuzner, Arianne C Plomp, Jia Newcombe, A. van der Goes, Jeffrey J. Bajramovic, J.M. van Noort

Publikováno v: Journal of Immunology, 8, 164, 4359-4366
Scopus-Elsevier

In the development of multiple sclerosis (MS), (re)activation of infiltrating T cells by myelin-derived Ags is considered to be a crucial step. Previously, αB-crystallin has been shown to be an important myelin Ag to human T cells. Since αB-crystal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c085f57ec72c48963f35f95379ce576f
https://pubmed.ncbi.nlm.nih.gov/10754336