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pro vyhledávání: '"J.M. Sousa Lobo"'
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Publikováno v:
Advanced drug delivery reviews. 189
The main limitation to the success of central nervous system (CNS) therapies lies in the difficulty for drugs to cross the blood-brain barrier (BBB) and reach the brain. Regarding its structure and enzymatic complexity, crossing the BBB is a challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033ae794eb6564fdef6054c6ddda51e0
https://pubmed.ncbi.nlm.nih.gov/35970274
https://pubmed.ncbi.nlm.nih.gov/35970274
Autor:
E.S. Da Silva, Santo Scalia, J.M. Sousa Lobo, Maria Bernadete de Souza Costa, Joao Sequeira Duarte, Joaquim L. Faria, Isabel Almeida, Paulo Costa
Publikováno v:
International Journal of Cosmetic Science. 41:585-593
The organic ultraviolet UVB filter 2-ethylhexyl 4-methoxycinnamate (EHMC) was encapsulated in microparticles (MPs) of sodium alginate and co-loaded with vitamin E (Vit.E) by an extrusion process using an aerodynamically assisted jetting (AAJ) methodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e7197036a272e3b85a6393fa8ae9ed
https://doi.org/10.1111/ics.12578
https://doi.org/10.1111/ics.12578
Autor:
Simone Souza da Costa Silva, Mariana Ferreira, Maria Emília Sousa, Isabel Almeida, Catarina Magalhães, A.S. Oliveira, Madalena Pinto, J.M. Sousa Lobo
Publikováno v:
International Journal of Cosmetic Science. 41:378-386
Objective Skin health and beauty are a cornerstone of general well-being in humans. Anti-ageing cosmetics are used to provide a healthy and youthful appearance. Among the different cosmetic actives, antioxidants are incorporated in anti-ageing produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef59f46c701d0bd68be176b5430cf6a7
https://doi.org/10.1111/ics.12551
https://doi.org/10.1111/ics.12551
Autor:
Ana Catarina Silva, J.M. Sousa Lobo, Maria Helena Amaral, João Nuno Moreira, Cláudia Pina Costa
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Epileptic seizures and anxiety crisis are severe conditions that require fast and effective treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited brain bioavailability, following oral, intravenous or rectal admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bfc3ac2abd6811d1c33811467d57cf
https://doi.org/10.1016/j.jconrel.2018.12.049
https://doi.org/10.1016/j.jconrel.2018.12.049
Autor:
Sara C. Cunha, Armando Peixoto, João Nuno Moreira, Luís Filipe Azevedo, J.M. Sousa Lobo, Cláudia Pina Costa, Ana Catarina Silva, Vera M. F. da Silva, Eva Gil-Martins, R. Silva
Publikováno v:
International journal of pharmaceutics. 607
Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ebf1c3a33aecbc5be97d6e74adca47
https://pubmed.ncbi.nlm.nih.gov/34324988
https://pubmed.ncbi.nlm.nih.gov/34324988
Autor:
Ana Catarina Silva, Alberto Teodorico Correia, J.M. Sousa Lobo, R. Silva, Vera M. F. da Silva, Cláudia Pina Costa
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Progesterone (PRG) plays a crucial role in the female reproductive system, being the vaginal route the most adequate for its administration, as this drug has an extensive hepatic first pass effect. Nonetheless, vaginal PRG dosage forms originate imme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1004e06c88312b12121aa01e33c934
https://pubmed.ncbi.nlm.nih.gov/32711115
https://pubmed.ncbi.nlm.nih.gov/32711115
Publikováno v:
International Journal of Pharmaceutics. 541:19-25
Purpose Several active compounds are sensitive to light, especially to the ultraviolet radiation (UV-R) leading to their degradation or modification, with lost or decrease of their biological activity. The aim of this study was to perform a systemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50508165d0d44c9a199f141fe2f4b6d0
https://doi.org/10.1016/j.ijpharm.2018.02.012
https://doi.org/10.1016/j.ijpharm.2018.02.012
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Background Current treatments for neurodegenerative diseases are challenging, due to the absence of full effective medicines. One of the major problems associated to these is the occurrence of non-targeting events, which leads to adverse effects and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e0e2656828070f5007f12490b788a3
https://doi.org/10.2174/1381612824666171128105305
https://doi.org/10.2174/1381612824666171128105305
Autor:
J.L. Figueiredo, A.R. Gaio, Cláudia Marques, V. Rocha, Isabel Almeida, Paulo Costa, J.M. Sousa Lobo
Publikováno v:
Food and Chemical Toxicology. 103:214-222
Assessment of toxic effects is mandatory before market placement of pharmaceutical and cosmetic products. Nanotoxicology is an emerging regulatory concern and still a challenging field. Topical application of resveratrol (RSV) has been extensively st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52404fe65d8ffc7cb40393ca00ba5334
https://doi.org/10.1016/j.fct.2017.03.017
https://doi.org/10.1016/j.fct.2017.03.017