Exploring Polar Headgroup Interactions Between Sphingomyelin and Ceramide with Infrared Spectroscopy

Autor: J.L.R. Arrondo, Igor de la Arada, Alicia Alonso, Félix M. Goñi, Emilio J. González-Ramírez

Publikováno v: Scientific Reports
Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco

Ceramide is a major actor in the sphingolipid signaling pathway elicited by various kinds of cell stress. Under those conditions ceramide (Cer) is produced in the plasma membrane as a product of sphingomyelin (SM) hydrolysis, and this may lead to apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c2132ebe4b82a9526718d899612a46
http://hdl.handle.net/10810/50110

Structural changes induced by acidic pH in human apolipoprotein B-100

Autor: J.L.R. Arrondo, Aitor Etxebarria, Asier Benito-Vicente, César Martín, Jose Carlos G. Milicua, Helena Ostolaza, José Angel Fernández-Higuero

Publikováno v: Scientific Reports

Acidification in the endosome causes lipoprotein release by promoting a conformational change in the LDLR allowing its recycling and degradation of LDL. Notwithstanding conformational changes occurring in the LDLR have expanded considerably, structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba11bf30a43aa39d0883dbd310aaf888
https://doi.org/10.1038/srep36324

Protein Stability Studied by Infrared Spectroscopy

Autor: J.L.R. Arrondo, M. Garcia-Pacios, I. de la Arada, J.Á. Fernández-Higuero

Publikováno v: Scopus-Elsevier

Infrared structural analysis usually implies a mathematical approach to extract the information contained in the protein amide bands. Thermal profiles have been used to help in the understanding of protein stability. A new approach, generalized 2D- I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c139c963c63e138066b67871fc2b55
https://doi.org/10.1080/13102818.2008.10817523

Binding of β-Amyloid (1–42) Peptide to Negatively Charged Phospholipid Membranes in the Liquid-Ordered State: Modeling and Experimental Studies

Autor: Massimo Masserini, Félix M. Goñi, Hasna Ahyayauch, Igor Tvaroška, Michal Raab, Jon V. Busto, Nagore Andraka, J.L.R. Arrondo

Publikováno v: Biophysical Journal

To explore the initial stages of amyloid β peptide (Aβ42) deposition on membranes, we have studied the interaction of Aβ42 in the monomeric form with lipid monolayers and with bilayers in either the liquid-disordered or the liquid-ordered (Lo) sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0daa9aeb0887896dc0eaa2f4b2b6f877
https://europepmc.org/articles/PMC3414892/

Structural and Functional Studies on the Interaction of Sodium Dodecyl Sulfate with β-Galactosidase

Autor: Arturo Muga, Carmelo Bernabeu, J.L.R. Arrondo, T. Bellon, J. Sancho

Publikováno v: Archives of Biochemistry and Biophysics. 300:451-457

The effect of sodium dodecyl sulfate (SDS) on enzyme activity, electrophoretic behavior, and conformation of Escherichia coli beta-galactosidase is presented. Fourier-transform infrared spectroscopy (FT-IR), previously used to study the structure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada4bbe974069ff8095169728355d69a
https://doi.org/10.1006/abbi.1993.1061