Zobrazeno 1 - 10
of 139
pro vyhledávání: '"J.L. Brazier"'
Autor:
J.L. Brazier, W. Elbast
Publikováno v:
Analusis. 27:218-223
Isotope ratio mase apectrometry and especially continuous flow leotope ratio mass spectromatry (CF-IRMS) expand rapidly in various fields including geochemistry, oil and earth sciences, environment, authentication of organic compounds. The last area
Autor:
J.L. Brazier, W. Elbast
Publikováno v:
Analusis. 27:228-234
13 C labelled urea and dedicated instrumentations. Benchtop isotope ratio mass spectrometers have been developed for such an application and thus, isotope ratio mass spectrometry came out into laboratories of clinical biochemistry. In this field, the
Publikováno v:
Analytical Letters. 32:3111-3130
Compound independent calibration (CIC) can be used to measure stable isotopically labeled molecules and their metabolites. This study was designed to demonstrate that gas chromatography coupled to atomic emission detection and CIC are useful analytic
Publikováno v:
Analytical Letters. 32:1627-1641
This study was designed to demonstrate that Gas Chromatography–Atomic Emission Detection (GC-AED) can be used to set in a Compound-independent calibration (CIC) for quantifying organic compounds with various chemical functions using one reference c
Publikováno v:
British Journal of Anaesthesia. 80:788-795
Previous studies of propofol (2,6-diisopropylphenol) pharmacology have shown that this widely used anaesthetic drug is extensively cleared from the body by conjugation of the parent molecule or its quinol metabolite. On the basis of potential influen
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 22:127-133
The aim of this work was to study the influence of labelling on caffeine metabolism according to the incubation mode. It has been observed that labelling induces an isotopic effect on metabolisation speed: apparent half-lives are systematically incre
Autor:
J.L. Brazier, S. Dautraix, J. P. Perdrix, S. Alamercery, Lionel Dutruch, Jérôme Guitton, M. Desage
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 693:59-70
Fentanyl, a synthetic opioid, undergoes important biotransformation to several metabolites. A gas chromatographic-mass spectrometric assay was applied for the simultaneous analysis of fentanyl and its major metabolites in biological samples. The iden
Publikováno v:
Analytical Letters. 29:1027-1039
Saffron is one of the most expensive spices. Consequently, it is not so difficult to understand that fraudulent saffron exists. Thus, it was interesting to study the most important flavouring component, in terms of aroma, volatile compound of saffron
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 19:119-124
The aim of this work was to study the action of methotrexate on the cytochrome P-450 hepatic monooxygenases and to follow the evolution of the metabolic processes with time, after oral and intra-peritoneal administration of these drugs to rats. In or
Autor:
Sylvie Normand, F. Billion-Rey, E.J. Jumeau, J.L. Brazier, R. Guilluy, Jean-Paul Riou, Christiane Pachiaudi
Publikováno v:
Analytica Chimica Acta. 259:193-202
An on-line gas chromatographic-isotope ratio mass spectrometric (IRMS) device consisting of a gas chromatograph, a column switching system, a continuous-flow dual inlet and an isotope ratio mass spectrometer is described. This device has been found s