Výsledky vyhledávání - "J.Léon E. Reubsaet"

Characterisation of π–π interactions which determine retention of aromatic compounds in reversed-phase liquid chromatography

Autor: Rune Vieskar, J.Léon E. Reubsaet

Publikováno v: Journal of Chromatography A. 841:147-154

This paper presents the influence of π–π interactions on the retention behaviour of aromate-rich and aromate-poor analytes separated on various chromatographic sorbents. The presence of π–π interactions between the analytes and a polymer base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ea23541a82424755a414bb6eacbc868
https://doi.org/10.1016/s0021-9673(99)00253-8

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Qualitative and quantitative aspects of the degradation of several tripeptides derived from the antitumour peptide antagonist [Arg6, D-Trp7,9, MePhe8] substance P{6–11}

Autor: Mohamed Bouyakhrichan, Esther H.M Belshof, Jos H. Beijnen, Rianne J. van Maanen, Willy J. M. Underberg, Yunus Kellekule, Auke Bult, J.Léon E. Reubsaet, Ed Hop, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 19:277-284

The tripeptides Arg-Trp-Phe, Arg-Trp-Phe-NH2, Phe-Trp-Arg and Phe-Trp-Arg-NH2 were subjected to a degradation study to get a more detailed insight into the degradation processes of the antitumor hexapeptide antagonist [Arg(6), D-Trp(7,9), MePhe(8)] s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf4c0e2a5ab2de09e96f763745ae0ae
https://doi.org/10.1016/s0731-7085(98)00115-0

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Analytical techniques used to study the degradation of proteins and peptides: chemical instability

Autor: Willy J. M. Underberg, Rianne J. van Maanen, J.Léon E. Reubsaet, J.A.Daniëlle Marchal, Auke Bult, Jos H. Beijnen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 17:955-978

Instability of peptides and proteins can be divided into two forms: chemical and physical instability. Chemical instability is due to modification/alteration of amino acid residues. There are several types of degradation reactions responsible for thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68310c5a17ca2c9db9711d71eeb3813f
https://doi.org/10.1016/s0731-7085(98)00063-6

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Oxidation of recombinant methionyl human granulocyte colony stimulating factor

Autor: Auke Bult, Ed Hop, J.Léon E. Reubsaet, Serge D. Scholten, Willy J. M. Underberg, Jos H. Beijnen, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 17:283-289

The oxidation of methionine residues in recombinant methionyl human granulocyte colony stimulating factor with hydrogen peroxide has been investigated. Kinetic data of the oxidation were obtained by using reversed phase-high performance liquid chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaeb1f2e3f6ffd8a0989e9c9068f6d6
https://doi.org/10.1016/s0731-7085(97)00199-4

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Characterisation of important interactions controlling retention behaviour of analytes in reversed-phase high-performance liquid chromatography

Autor: Kiyokatsu Jinno, J.Léon E Reubsaet

Publikováno v: TrAC Trends in Analytical Chemistry. 17:157-166

Interactions between an analyte and the surface of the stationary phase are discussed with relation to the physico-chemical properties of both analyte and the surface resin. Hydrophobic and electrostatic interactions give important contributions to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1ea51433da06e9337c01033a6f07b33
https://doi.org/10.1016/s0165-9936(97)00127-1

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Precolumn fluorescence derivatization of the antagonist [Arg6,D-Trp7,9,MePhe8]-substance P[6-11] with benzoin in high-performance liquid chromatography and selective detection of arginine-containing fragments in its degradation products

Autor: Auke Bult, Hua Cui, J.Léon E. Reubsaet

Publikováno v: Journal of chromatography. A. 736(1-2)

Precolumn fluorescence derivatization for the determination of the antagonist [Arg6, d -Trp7,9,MePhe8]-Substance P 6–11 (antagonist G) using benzoin in HPLC was studied. Under the conditions chosen (0.067 M NaOH, heating at 100°C for 10 s), a good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df38e56f1e6e0dd4467e3920f83ae3db
https://pubmed.ncbi.nlm.nih.gov/8673253

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