Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J.K. Medema"'
Autor:
Lanju Zhang, Gwen Levy, Marc C. Levesque, Johanne Martel-Pelletier, Francisco J. Blanco, Thomas J. Schnitzer, Philip G. Conaghan, J.K. Medema, Li Wang, Jean-Pierre Pelletier, Roy Fleischmann, Charles Peterfy, Francis Berenbaum, Ole Vaeterlein, Matthew P. Kosloski, Henning Bliddal, Gurjit S. Kaeley, Su Chen, Wei Liu, Sheng Feng
Publikováno v:
Arthritis & Rheumatology. 71:1056-1069
Objective: To assess the efficacy and safety of the anti–interleukin‐1α/β (anti–IL‐1α/β) dual variable domain immunoglobulin lutikizumab (ABT‐981) in patients with knee osteoarthritis (OA) and evidence of synovitis. Methods: Patients (n
Autor:
Yuni Fang, Ruth Wittoek, Prashant Bansal, Sheng Feng, Charles Peterfy, Roy Fleischmann, Li Wang, Gwen Levy, Francis Berenbaum, Féline P B Kroon, Wei Liu, Su Chen, Margreet Kloppenburg, Ida K. Haugen, Désirée van der Heijde, J.K. Medema, Mary Saltarelli, Marc C. Levesque
Publikováno v:
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2019, 78 (3), pp.413-420. ⟨10.1136/annrheumdis-2018-213336⟩
Annals of the Rheumatic Diseases, 78(3), 413-420. BMJ PUBLISHING GROUP
ANNALS OF THE RHEUMATIC DISEASES
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2019, 78 (3), pp.413-420. ⟨10.1136/annrheumdis-2018-213336⟩
Annals of the Rheumatic Diseases, 78(3), 413-420. BMJ PUBLISHING GROUP
ANNALS OF THE RHEUMATIC DISEASES
ObjectiveTo assess the efficacy, safety, pharmacokinetics and pharmacodynamics of the anti-interleukin (IL)-1α/β dual variable domain immunoglobulin lutikizumab (ABT-981) in erosive hand osteoarthritis (HOA).MethodsPatients with ≥1 erosive and
Autor:
J.K. Medema, S.B. Abramson, Mukundan Attur, Morten Karsdal, P. Jiang, M.J. Saltarelli, F. Hong, B.A. Hendrickson, S.X. Wang, Matthew P. Kosloski, Richard A. Preston, Carlos J. Lozada
Publikováno v:
Osteoarthritis and Cartilage. 25:1952-1961
Summary Objective To investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ABT-981, a human dual variable domain immunoglobulin simultaneously targeting interleukin (IL)-1α and IL-1β, in patients with knee osteoarthritis (
Autor:
J.K. Medema, Sjoerd van Beest, Féline P B Kroon, Frédérique Gandjbakhch, Charles Peterfy, Su Chen, Violaine Foltz, Margreet Kloppenburg, Philip G. Conaghan, Iris Eshed, Marc C. Levesque, Lanju Zhang, Ida K. Haugen, Mikkel Østergaard, Harry K. Genant
Publikováno v:
Kroon, F P B, Van Beest, S, Gandjbakhch, F, Peterfy, C G, Chen, S, Conaghan, P G, Eshed, I, Foltz, V, Genant, H K, Haugen, I K, Medema, J K, Østergaard, M, Zhang, L, Levesque, M C & Kloppenburg, M 2019, ' Longitudinal reliability of the OMERACT thumb base osteoarthritis magnetic resonance imaging scoring system (TOMS) ', Journal of Rheumatology, vol. 46, no. 9, pp. 1228-1231 . https://doi.org/10.3899/jrheum.180949
Journal of Rheumatology, 46(9), 1228-1231
Journal of Rheumatology, 46(9), 1228-1231
Objective.To assess the longitudinal reliability of the Outcome Measures in Rheumatology (OMERACT) Thumb base Osteoarthritis Magnetic resonance imaging (MRI) Scoring system (TOMS).Methods.Paired MRI of patients with hand osteoarthritis were scored in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d6d7a83f37cfd2f90eb00e316d6ce4
https://hdl.handle.net/1887/120520
https://hdl.handle.net/1887/120520
Autor:
Matthew P. Kosloski, Sandeep Dutta, J.K. Medema, Ralf Loebbert, Sandra L. Goss, Wei Liu, S.X. Wang, Jia Liu
Publikováno v:
The Journal of Clinical Pharmacology. 56:1582-1590
The interleukin (IL)-1 family of proinflammatory cytokines are thought to play a significant role in the structural progression of osteoarthritis and its associated symptoms. IL-1α and IL-1β are 2 distinct cytokines found in the cartilage, synovial
Autor:
Li Chun Wang, J.K. Medema, Charles Peterfy, Marc C. Levesque, Henning Bliddal, Wei Liu, Thomas J. Schnitzer, G. Levy, P.G. Conaghan, Johanne Martel-Pelletier, O. Vaeterlein, J.-P. Pelletier, Lanju Zhang, Su Chen, Francisco J. Blanco, Roy Fleischmann, Francis Berenbaum
Publikováno v:
Saturday, 16 JUNE 2018.
Background Animal studies suggested that inhibiting IL-1α/β with lutikizumab (formerly, ABT-981) may reduce pain and slow structural progression in OA. Objectives This study (NCT02087904; ILLUSTRATE-K) assessed the safety and efficacy of lutikizuma
Autor:
Y. Luo, Virginia B. Kraus, Sheng Feng, Li Chun Wang, Su Chen, L. Cui, Marc C. Levesque, Rajesh V. Kamath, Lanju Zhang, J.K. Medema, Charles Peterfy
Publikováno v:
Saturday, 16 JUNE 2018.
Background Development of disease-modifying drugs for OA has been challenging, partly due to lack of predictive biomarkers. Objectives Our primary objective was to identify baseline (BL) biomarkers predicting greater treatment effects on WOMAC pain a
Autor:
Charles Peterfy, D. van der Heijde, Wei Liu, Margreet Kloppenburg, Frank P. Kroon, G. Levy, Li Chun Wang, J.K. Medema, Marc C. Levesque, Ida K. Haugen, Su Chen, Roy Fleischmann, Francis Berenbaum
Publikováno v:
Oral Presentations.
Background No approved OA therapies reduce pain and slow joint damage. Mouse data suggested that inhibiting IL-1α and -1β with ABT-981 would reduce pain and slow structural progression in EHOA. Objectives To test the efficacy and safety of ABT-981
Aims: To compare healthcare resource utilization and costs between patients aged 18–64 years with osteoarthritis (OA) and matched controls without OA in a privately insured population. Methods: Patients with OA were selected from de-identified US-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04015636826874597e97c800ab36899d
https://hdl.handle.net/10453/123896
https://hdl.handle.net/10453/123896
Publikováno v:
Osteoarthritis and Cartilage. 24
s / Osteoarthritis and Cartilage 24 (2016) S63eS534 S235 practice but many providers believe that the goal of SDM is to guide a patient to the treatment option that the provider feels is most appropriate. Time was a limiting factor to using SDM and D