Zobrazeno 1 - 10
of 73
pro vyhledávání: '"J.J.M. van de Sandt"'
Autor:
S.C. Wilkinson, E. Robinson, Faith M. Williams, P.L. Carmichael, J.-P. Payan, I. Dick, J.C. Limasset, G. Korinth, J.J.M. van de Sandt, K.H. Schaller, W.J.M. Maas, Pietro Sartorelli, S. Cage, S. Kenyon, F Larese, J.A. van Burgsteden, Jesper Bo Nielsen, L. Montomoli
Publikováno v:
van de Sandt, J J M, Burgsteden, J A, Cage, S, Carmichael, P L, Dick, I, Kenyon, S, Korinth, G, Larese, F, Limasset, J C, Maas, W J M, Montomoli, L, Nielsen, J B, Payan, J-P, Robinson, E, Sartorelli, P, Schaller, K H, Wilkinson, S & Williams, F M 2004, ' In vitro prediction of skin absorption of caffeine, testosterone and benzoic acid: a multi-centre comparison study. ', Regulatory Toxicology and Pharmacology, vol. 39, pp. 271-81 .
Università degli Studi di Siena-IRIS
Regulatory Toxicology and Pharmacology, 3, 39, 271-281
Università degli Studi di Siena-IRIS
Regulatory Toxicology and Pharmacology, 3, 39, 271-281
To obtain better insight into the robustness of in vitro percutaneous absorption methodology, the intra- and inter-laboratory variation in this type of study was investigated in 10 European laboratories. To this purpose, the in vitro absorption of th
Publikováno v:
Toxicology in Vitro, 6, 14, 523-530
Toxicology in Vitro 14 (2000)
Toxicology in Vitro, 14, 523-530
Toxicology in Vitro 14 (2000)
Toxicology in Vitro, 14, 523-530
Precision-cut liver slices are frequently used to study hepatic toxicity and metabolism of xenobiotics in vitro. Successful cryopreservation techniques will enhance an efficient and economic use of scarcely available (human) liver tissue. For primary
Autor:
Eric D. Schoen, W.J.M. Maas, J.P. Groten, H. J. Koster, J.J.M. van de Sandt, I. A. M. de Graaf
Publikováno v:
Cryobiology, 40, 250-263
Cryobiology 40 (2000)
Cryobiology, 3, 40, 250-263
Cryobiology 40 (2000)
Cryobiology, 3, 40, 250-263
A number of studies on the cryopreservation of precision-cut liver slices using various techniques have been reported. However, the identification of important factors that determine cell viability following cryopreservation is difficult because of l
Autor:
Ronald Walker, J.J.M. van de Sandt, José V. Castell, B Schilter, G Kozianowski, A.G.A.A Knapp, K Walton, Marcel Roberfroid
Publikováno v:
Food and Chemical Toxicology, 12, 37, 1175-1197
The acceptable daily intake (ADI) for food additives is commonly derived from the NOAEL (no-observed-adverse-effect level) in long-term animal in vivo studies. To derive an ADI a safety or uncertainty factor (commonly 100) is applied to the NOAEL in
Autor:
Emanuela Corsini, M. Fartasch, Catherine Cohen, N. Fusenig, Roland Roguet, Maria Ponec, J.J.M. van de Sandt, Manfred Liebsch, D.J. Benford, David J. Esdaile, C. Barker, A. de Fraissinette
Publikováno v:
Alternatives to Laboratory Animals. 27:723-743
This is the report of the thirty-eighth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAMs main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scient
Autor:
J. De Jongh, J.M. Frazier, Michael Gülden, Christoph A. Reinhardt, Bas J. Blaauboer, G.L. Kedderis, André Guillouzo, K. Groen, J. B. Houston, G. Johanson, A.M. Hissink, C.T.A. Evelo, M.K. Bayliss, J.J.M. van de Sandt, G. Semino, José V. Castell
Publikováno v:
Alternatives to Laboratory Animals. 24:473-497
Autor:
J.J.M. van de Sandt, Victor J. Feron
Publikováno v:
Alternatives to Laboratory Animals. 24:173-178
With rapidly increasing knowledge of toxicological processes, the scientific value and relevance of toxicity studies for risk assessment must be re-evaluated. In this paper, it is proposed that the rigid risk evaluation currently required should be r
Publikováno v:
In Vitro Cellular & Development Biology : Animal, 10, 31, 761-766
Epidermal cell proliferation and differentiation were investigated in vitro after exposure to the anionic surfactant sodium dodecyl sulfate (SDS). Human skin organ cultures were exposed topically to various concentrations of SDS for 22 h, after which
Autor:
J.J.M. van de Sandt, Bas J. Blaauboer, J. De Jongh, Erna M. Hissink, P.J. van Bladeren, J.J.P. Bogaards, B. van Ommen
Publikováno v:
Toxicology in Vitro, 4, 9, 537-542
Within the framework of in vitro alternatives for in vivo safety assessment, the kinetic behaviour of a compound can be described by biokinetic models. These models, with emphasis on the physiologically based pharmacokinetic models, need a variety of
Publikováno v:
Regulatory Toxicology and Pharmacology, 1, 53, 70-80
The objectives of REACH cannot be achieved under the current risk assessment approach. A change in mind set among all the relevant stakeholders is needed: risk assessment should move away from a labor-intensive and animal-consuming approach to intell
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