Výsledky vyhledávání - "J.J.M. Holthuis"

Electrochemistry of potentially bioreductive alkylating quinones

Autor: S.J. Postma Kelder, R.J. Driebergen, Willem Verboom, Lambert H.M. Janssen, Ed E. Moret, J.J.M. Holthuis, J.S. Blauw, W.E. van der Linden, David N. Reinhoudt

Publikováno v: Analytica Chimica Acta. 257:257-273

The concept of bioreductive alkylation as a mechanism of action of aziridinylquinoid anticancer agents has been investigated by the use of electrochemical techniques. Properly substituted aziridinylquinones are activated by an electrochemical step (r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5898ac447ec58c84bbf7ef85b602f767
https://doi.org/10.1016/0003-2670(92)85179-a

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On-line method for the generation of electrochemical reagent generation for liquid chromatography with luminol-based chemiluminescence detection

Autor: O.M. Steijger, J.J.M. Holthuis, G.J. de Jong, U.A.Th. Brinkman

Publikováno v: Journal of Chromatography A. 557:13-21

An on-line method for the generation of electrochemical reagent for liquid chromatography, with luminol-based chemiluminescence detection, has been developed. An ESA Coulochem guard cell, equipped with a porous graphite working electrode, operated at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d250aa24e30056664ece1b7b9b9ca015
https://doi.org/10.1016/s0021-9673(01)87118-1

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Mechanistic study on the derivatization of aliphatic carboxylic acids in aqueous non-ionic micellar systems

Autor: J.M. Reijn, U.A.Th. Brinkman, M.H. Post, F.A.L. Van Der Horts, Auke Bult, J.J.M. Holthuis

Publikováno v: Journal of Chromatography A. 507:351-366

A model is proposed for the derivatization mechanism of carboxylic acids with a fluorescent label, 4-bromomethyl-7-methoxycoumarin, in an aqueous non-ionic micellar system with the use of a tetraalkylammonium ion-pairing cation. Using experimentally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e7f807a2886c6b392356b735ce77b75
https://doi.org/10.1016/s0021-9673(01)84213-8

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Automated high-performance liquid chromatographic determination of plasma free fatty acids using on-line derivatization with 9-bromomethylacridine based on micellar phase-transfer catalysis

Autor: U.A.Th. Brinkman, M.H. Post, J.J.M. Holthuis, F.A.L. Van Der Horst

Publikováno v: Journal of Chromatography A. 500:443-452

The on-line use of micellar phase-transfer catalysis is described for the automated reversed-phase high-performance liquid chromatographic (RP-HPLC) determination of free fatty acids in plasma; minimum manual sample handling is involved. After diluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6454fcc0b0fe44cd02fa4b2cb8fac5
https://doi.org/10.1016/s0021-9673(00)96084-9

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Electrochemistry of potential bioreductive alkylating quinones

Autor: W.E. van der Linden, S.J. Postma Kelder, R.J. Driebergen, J.J.M. Holthuis, Willem Verboom, David N. Reinhoudt, J.S. Blauw

Publikováno v: Analytica Chimica Acta. 234:285-307

The reduction mechanism of 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone (Diaziquone, AZQ) and several model compounds of the mono- and bis(1-aziridinyl)quinone type at the dropping mercury electrode in aqueous solutions was stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d98da87c297541fbfb587475698dec54
https://doi.org/10.1016/s0003-2670(00)83570-9

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High-performance liquid chromatographic determination of amantadine in urine after micelle-mediated pre-column derivatization with 1-fluoro-2,4-dinitrobenzene

Autor: U.A.Th. Brinkman, J.J.M. Holthuis, F.A.L. Van Der Horst, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 8:799-804

Cationic micelles have been used for the derivatization of the anti-Parkinson drug amantadine with the chromophore 1-fluoro-2,4-dinitrobenzene in urine. In the presence of 90 mM cetyltrimethylammonium bromide (CTAB), the conversion of amantadine into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158c074ea4ae4a7673fc34047d547555
https://doi.org/10.1016/0731-7085(90)80124-8

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Comparative study on the determination of the anti-neoplastic drug teniposide in plasma using micellar liquid chromatography and surfactant-mediated plasma clean-up

Autor: F.A.L. Van Der Horst, M.H. Post, U.A.Th. Brinkman, Jan Teeuwsen, J.J.M. Holthuis, M.A.J. van Opstal

Publikováno v: Journal of chromatography. 567(1)

The potential of micellar liquid chromatography and of an on-line surfactant-mediated sample clean-up, which involves column-switching prior to conventional reversed-phase high-performance liquid chromatography, has been evaluated for the determinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9523fdea37c2b56599144b6ab6c6cc6d
https://pubmed.ncbi.nlm.nih.gov/1918243

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Electrochemistry of podophyllotoxin derivatives

Autor: W. J. van Oort, D.E.M.M. Vendrig, Petr Zuman, J.J.M. Holthuis

Publikováno v: Journal of Electroanalytical Chemistry and Interfacial Electrochemistry. 220:101-124

Oxidation of the anions of teniposide (I) and its aglycone (III) occurs over the pH range from 3 to 12 in two one-electron waves. The loss of the first electron yields a radical, the second a phenoxenium ion. The latter is converted by nucleophilic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6a47dbdb0b3f266fc3b477fef43a3d4
https://doi.org/10.1016/0022-0728(87)88007-5

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