Using a biology-based model (DEBtox) to analyze bioassays in ecotoxicology: Opportunities and recommendations

Autor: Alexandre R.R. Pery, J.J.M. Bedaux, Bernard Vollat, Sebastiaan A.L.M. Kooijman, Patrick Flammarion, Jeanne Garric

Publikováno v: Environmental Toxicology and Chemistry. 21:459-465

The conventional analysis of bioassays does not account for biological significance. However, mathematical models do exist that are realistic from a biological point of view and describe toxicokinetics and effects on test organisms of chemical compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b46d6f8437e1a9f2721194e77f97c08
https://doi.org/10.1002/etc.5620210232

Analysis of bioassays with time-varying concentrations

Autor: Alexandre R.R. Pery, C. Zonneveld, Sebastiaan A.L.M. Kooijman, J.J.M. Bedaux

Publikováno v: Pery, A R R, Bedaux, J J M, Zonneveld, C & Kooijman, S A L M 2001, ' Analysis of bioassays with time-varying concentrations. ', Water Research, vol. 35, pp. 3825-3832 . https://doi.org/10.1016/S0043-1354(01)00106-3
Water Research, 35, 3825-3832. Elsevier Limited

In the analysis of ecotoxicological bioassays the concentration of the test compounds is assumed to be constant. In many situations this assumption is questionable, as various processes may cause a substantial decline in the concentration during expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4819bb955c8a30ded2405af79428e8a2
https://research.vu.nl/en/publications/a807d0e9-525c-41ab-950f-bb142ad4f8c0

[Untitled]

Autor: J.A.C. Verkley, J.J.M. Bedaux, F. E. C. Sneller, W. M. Ten Bookum, Henk Schat, E.C.M. Noordover

Publikováno v: Ecotoxicology. 8:167-175

Phytochelatins (PCs) are known to detoxify heavy metals in plants. This study aimed to investigate the possibility of using PCs as a biomarker for chronic Cd toxicity in Silene vulgaris. For this purpose, the effects of Cd on growth rate, related to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec364f8c4d2990da049ba0d98b2d2285
https://doi.org/10.1023/a:1026440213649

Analysis of toxicity tests on fish growth

Autor: J.J.M. Bedaux, Sebastiaan A.L.M. Kooijman

Publikováno v: Water Research. 30:1633-1644

We present a statistical analysis of bioassays for fish growth, such as the routine toxicity test that is described in the OECD guideline 210. The analysis is based on the Dynamic Energy Budget theory and a one-compartment kinetics for the toxic comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e7efe2842123a4c77ecde7c2e54a9d3
https://doi.org/10.1016/0043-1354(96)00057-7

Lethal body concentrations and accumulation patterns determine time-dependent toxicity of cadmium in soil arthropods

Autor: C.J.A.M. Doodeman, J.J.C. van der Pol, C.A.M. van Gestel, T. Crommentuijn, A. Doornekamp, J.J.M. Bedaux

Publikováno v: Environmental Toxicology and Chemistry. 13:1781-1789

Time-dependent toxicity in bioassays is usually explained in terms of uptake and elimination kinetics of the toxicant. By comparing different species with essentially different accumulation kinetics, a firm test of this concept may be made. This arti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::606da0ce5e693dc1e884e3e6c3f55240
https://doi.org/10.1002/etc.5620131109