Zobrazeno 1 - 10
of 132
pro vyhledávání: '"J.J. Picard"'
Publikováno v:
Neurotoxicology and Teratology. 19:163-169
The expression domain of Otx2, a gene essential for the development of the fore- and midbrain, has previously been shown to be affected by exposure to all-trans-retinoic acid (AT-RA). However, morphological abnormalities of the fore- and midbrain ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988590e4b0619e9939fc306fb42ee48e
https://doi.org/10.1016/s0892-0362(97)00017-2
https://doi.org/10.1016/s0892-0362(97)00017-2
Publikováno v:
Developmental Brain Research. 93:62-69
Prenatal valproic acid (VPA) exposure results in neural tube defects and in the fetal valproate syndrome (FVS), associated with developmental delay. In the present study we investigate the alterations induced by VPA and one of its metabolite, 4-en-VP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b86e335decc3d846b355fa9191e505e
https://doi.org/10.1016/0165-3806(96)00031-4
https://doi.org/10.1016/0165-3806(96)00031-4
Publikováno v:
Teratology. 53:10-20
The embryotoxic and dysmorphogenic effects of mercuric chloride (HgCl2) have been studied in mouse embryos cultured in vitro. In addition, the alterations induced in the developing branchial nerves and ganglia were analyzed. Mouse embryos with 6-8 pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cab3b5ee57705f2e39d8bf197de9eeb
https://doi.org/10.1002/(sici)1096-9926(199601)53:1<10::aid-tera2>3.0.co
https://doi.org/10.1002/(sici)1096-9926(199601)53:1<10::aid-tera2>3.0.co
Publikováno v:
Toxicology in Vitro. 9:671-675
Rat embryos explanted at the presomite stage and cultured through limb bud stages develop to well formed embryos and exhibit growth and differentiation which mimic those observed in vivo at corresponding stages. In contrast, the culture of presomite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae22e59644691f365aea552a2396c9bd
https://doi.org/10.1016/0887-2333(95)00064-f
https://doi.org/10.1016/0887-2333(95)00064-f
Publikováno v:
Alternatives to Laboratory Animals. 23:677-687
The culture of whole post-implantation rodent embryos has become an important tool in developmental biology and toxicology. Since the establishment of this system, rat serum has been the main culture medium used. In this study, we demonstrate that me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790f164cb358086bdd9f348bf4243784
https://doi.org/10.1177/026119299502300521
https://doi.org/10.1177/026119299502300521
Publikováno v:
Toxicology in Vitro. 7:719-725
The developmental tables of early somite mouse embryos that are presently available from the literature give clear and useful descriptions of the differentiation at successive stages. However, they provide no easy access to the correlation between th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac822e564d976bd0bad8d9541bc5cb6a
https://doi.org/10.1016/0887-2333(93)90073-e
https://doi.org/10.1016/0887-2333(93)90073-e
Autor:
M.C. Jacobs, P. Berthet, G. Gofflot, P. Therasse, J.J. Picard, G. Van Maele-Fabry, K. Despontin, J.P. Desager, Jean-Marie Lachapelle, C. Lecart, E. Lenoir
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 7(6)
Sera of 20 patients treated with 20-40 mg isotretinoin/day were tested for embryotoxicity potential. For each patient, the first sample was taken before treatment (control sample) and the second was taken 2 months after the start of treatment (treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b02a3dbc6a473bab9b3ebce808f8a6e
https://pubmed.ncbi.nlm.nih.gov/20732284
https://pubmed.ncbi.nlm.nih.gov/20732284
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 7(6)
Plasminogen activator (PA) activity has been suggested to be an important determinant of cell migration and tissue modelling during organogenesis. We have postulated that in the developing embryo, any abnormal modulation of this enzymatic activity ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bea21632ef831e2fe6cb09ba4e04e97
https://pubmed.ncbi.nlm.nih.gov/20732276
https://pubmed.ncbi.nlm.nih.gov/20732276
Publikováno v:
Neurotoxicology and teratology. 20(6)
Exposure of embryos to an excess of retinoic acid (RA) modifies the spatio-temporal pattern of expression of developmental genes. RA regulates the expression of target genes through binding of the retinoid nuclear receptors (RARs and RXRs), as hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21016f60601718330e20c98e8ee8ecd5
https://pubmed.ncbi.nlm.nih.gov/9831119
https://pubmed.ncbi.nlm.nih.gov/9831119
Autor:
Françoise Gofflot, M.C. Nassogne, T. Etzion, G. Van Maele-Fabry, J.J. Picard, Philippe Evrard
Publikováno v:
Neurotoxicology and teratology. 17(4)
Mouse embryos displaying 8 to 9 pairs of somites were cultured during 26 h in presence of 0.75 mM of VPA, or of 1 mM of 4-en-VPA. These concentrations induced approximately 50% of dysmorphogenic embryos. Irregular suture of caudal neural tube, abnorm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73bf6eb37e23543da4c81fa131155ad
https://pubmed.ncbi.nlm.nih.gov/7565489
https://pubmed.ncbi.nlm.nih.gov/7565489