Epigenetics as a mechanism linking developmental exposures to long-term toxicity

Autor: Rémy Slama, Jia Chen, Toshihiro Kawamoto, Alvaro Puga, Karine Audouze, Zdenko Herceg, K Nohara, Margaret R. Karagas, Erik Melén, W Yan, Robert Barouki, Y Xia, Philippe Grandjean, L Chadwick, J.J. Heindel, J Beckers

Publikováno v: Barouki, R, Melén, E, Herceg, Z, Beckers, J, Chen, J, Karagas, M, Puga, A, Xia, Y, Chadwick, L, Yan, W, Audouze, K, Slama, R, Heindel, J, Grandjean, P, Kawamoto, T & Nohara, K 2018, ' Epigenetics as a mechanism linking developmental exposures to long-term toxicity ', Environment International, vol. 114, pp. 77-86 . https://doi.org/10.1016/j.envint.2018.02.014
Environ. Int. 114, 77-86 (2018)
Environment International, Vol 114, Iss, Pp 77-86 (2018)

A variety of experimental and epidemiological studies lend support to the Developmental Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for mid- and long-term effects of early-life exposures remain unclear. Epigene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9013fa2a68ced530c0651317b5506483
https://findresearcher.sdu.dk:8443/ws/files/151774435/nihms947551.pdf

PPTOX III: Environmental Stressors in the Developmental Origins of Disease - Evidence and Mechanisms

Autor: Robert Barouki, Peter D. Gluckman, Thaddeus T. Schug, Mark A. Hanson, J.J. Heindel, Philippe Grandjean

Publikováno v: Schug, T T, Barouki, R, Gluckman, P D, Grandjean, P, Hanson, M & Heindel, J J 2013, ' PPTOX III: Environmental Stressors in the Developmental Origins of Disease-Evidence and Mechanisms ', Toxicological Sciences, vol. 131, no. 2, pp. 343-350 . https://doi.org/10.1093/toxsci/kfs267

Fetal and early postnatal development constitutes the most vulnerable time period of human life in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa23dba2de07c11e722abc33921dabb
https://portal.findresearcher.sdu.dk/da/publications/d5b5e3f1-b9d8-417a-8b2f-36358847388f

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Exposure to tetrachlorodibenzo-p-dioxin (TCDD) alters fetal thymocyte maturation

Autor: B L Blaylock, Steven D. Holladay, Michael I. Luster, C E Comment, J.J. Heindel

Publikováno v: Toxicology and Applied Pharmacology. 112:207-213

We previously reported that thymic atrophy and reduced thymic cellularity associated with prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice are characterized by quantitative alerations in the number of thymocytes expressing CD4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05231245f60130b09b8d6fc31728149
https://doi.org/10.1016/0041-008x(92)90189-y

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.