Zobrazeno 1 - 10
of 38
pro vyhledávání: '"J.H.T.M. Ploemen"'
Autor:
P.J. van Bladeren, L.W. Wormhoudt, Jan N. M. Commandeur, J.H.T.M. Ploemen, I de Waziers, M. J. Oudshoorn, Philippe Beaune, Nico P. E. Vermeulen, Guido R. M. M. Haenen, T. Watabe
Publikováno v:
Ploemen, J P H T M, Wormhoudt, L W, Haenen, G R M M, Oudshoorn, M J, Commandeur, J N M, Vermeulen, N P E, De Waziers, I, Beaune, P H, Watabe, T & van Bladeren, P J 1997, ' The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: The case of ethylene dibromide. ', Toxicology and Applied Pharmacology, vol. 143, pp. 56-69 . https://doi.org/10.1006/taap.1996.8004
Toxicology and Applied Pharmacology, 143, 56-69
Toxicology and Applied Pharmacology, 143, 56-69. Academic Press Inc.
Toxicology and Applied Pharmacology 143 (1997)
Toxicology and Applied Pharmacology, 143, 56-69
Toxicology and Applied Pharmacology, 143, 56-69. Academic Press Inc.
Toxicology and Applied Pharmacology 143 (1997)
Ethylene dibromide (1,2-dibromoethane, EDB) is metabolized by two routes: a conjugative route catalyzed by glutathione S -transferases (GST) and an oxidative route catalyzed by cytochrome P450 (P450). The GST route is associated with carcinogenicity.
Autor:
Jan N. M. Commandeur, L.W. Wormhoudt, Philippe Beaune, P.J. van Bladeren, Nico P. E. Vermeulen, I de Waziers, J.H.T.M. Ploemen
Publikováno v:
Chemico-Biological Interactions, 101, 175-192. Elsevier Ireland Ltd
Wormhoudt, L W, Ploemen, J P H T M, de Waziers, I, Commandeur, J N M, Beaune, P H, van Bladeren, P J & Vermeulen, N P E 1996, ' Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. ', Chemico-Biological Interactions, vol. 101, pp. 175-192 . https://doi.org/10.1016/0009-2797(96)03723-4
Chemico-Biological Interactions, 3, 101, 175-192
Wormhoudt, L W, Ploemen, J P H T M, de Waziers, I, Commandeur, J N M, Beaune, P H, van Bladeren, P J & Vermeulen, N P E 1996, ' Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. ', Chemico-Biological Interactions, vol. 101, pp. 175-192 . https://doi.org/10.1016/0009-2797(96)03723-4
Chemico-Biological Interactions, 3, 101, 175-192
1,2-Dibromoethane (1,2-DBE) is mainly used as an additive in leaded gasoline and as a soil fumigant and it is a suspected carcinogen in humans. In this study, the oxidative bioactivation of 1,2-DBE to 2-bromoacetaldehyde (2-BA) was studied using hete
Autor:
P.J. van Bladeren, J.H.T.M. Ploemen, Nico P. E. Vermeulen, Jan N. M. Commandeur, L.W. Wormhoudt, B. van Ommen
Publikováno v:
Chemico-Biological Interactions, 99, 41-53. Elsevier Ireland Ltd
Wormhoudt, L W, Ploemen, J P H T M, Commandeur, J N M, van Ommen, B, van Bladeren, P J & Vermeulen, N P E 1996, ' Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats. ', Chemico-Biological Interactions, vol. 99, pp. 41-53 . https://doi.org/10.1016/0009-2797(95)03659-8
Wormhoudt, L W, Ploemen, J P H T M, Commandeur, J N M, van Ommen, B, van Bladeren, P J & Vermeulen, N P E 1996, ' Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats. ', Chemico-Biological Interactions, vol. 99, pp. 41-53 . https://doi.org/10.1016/0009-2797(95)03659-8
The cytochrome P450 (P450) catalyzed oxidation of 1,2-dibromoethane (1,2-DBE) to 2-bromoacetaldehyde (2-BA) was measured in liver microsomes of both control and differentially induced rats. 2-BA formation was quantified by derivatization of 2-BA with
Publikováno v:
Chemico-Biological Interactions. 90:87-99
The reversible and irreversible inhibition of human glutathione S-transferases (GST) by dopamine, alpha-methyldopa and their 5-S-glutathionyl conjugates (termed 5-GSDA and 5-GSMDOPA, respectively) was studied using purified isoenzymes. The reversible
Publikováno v:
Food and Chemical Toxicology 31 (1993)
Food and Chemical Toxicology, 31, 475-482
Food and Chemical Toxicology, 31, 475-482
The reversible and irreversible inhibition of glutathione S-transferases (GST) by caffeic acid [3-(3,4-dihydroxyphenyl)-2-propenoic acid] was studied in vitro using purified rat isoenzymes, and in vivo in male Wistar (WU) rats. The concentrations of
Autor:
S.S. Gau, J.J.P. Bogaards, P.J. van Bladeren, B. van Ommen, Terrence J. Monks, J.H.T.M. Ploemen
Publikováno v:
Biochemical Journal. 276:661-666
The irreversible inhibition of the rat glutathione S-transferase (GST) isoenzyme 1-1 by a series of halogenated 1,4-benzoquinones and their GSH conjugates was studied quantitatively by analysing the time course of enzyme inactivation. With increasing
Publikováno v:
Biochemical Pharmacology. 40:1631-1635
Ethacrynic acid, a potent inhibitor of glutathione S-transferases (GST), has been shown to enhance the cytotoxicity of chlorambucil in drug resistant cell lines, but a definite mechanism has not been established. Both covalent binding to GST and reve
Autor:
P.J. van Bladeren, J. van der Greef, S. Jespersen, C.J.M. Rompelberg, J.H.T.M. Ploemen, Hans Verhagen
Publikováno v:
Chemico-Biological Interactions, 1-2, 99, 85-97
The irreversible and reversible inhibition of glutathione S-transferases (GSTs) by eugenol was studied in rat, mouse and man. Using liver cytosol of human, rat and mouse, species differences were found in the rate of irreversible inhibition of GSTs b
Autor:
P.J. van Bladeren, A.E. Keyzer, C. van Amersfoort, J.G. Schefferlie, J.H.T.M. Ploemen, M. van Iersel, I. Struik
Publikováno v:
Chemico-Biological Interactions, 102, 117-132
Chemico-Biological Interactions 102 (1996)
Chemico-Biological Interactions 102 (1996)
The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the excreted glutathione (GSH) conjugate (S-(2,4-dinitrophenyl)glutathione
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915c202f6363fcfab16a5252186df598
https://research.wur.nl/en/publications/inhibition-of-glutathione-s-transferase-activity-in-human-melanom
https://research.wur.nl/en/publications/inhibition-of-glutathione-s-transferase-activity-in-human-melanom
Autor:
P.J. van Bladeren, Nico P. E. Vermeulen, M. van Iersel, Jan N. M. Commandeur, J.H.T.M. Ploemen, L.W. Wormhoudt
Publikováno v:
Ploemen, J P H T M, van Iersel, M, Wormhoudt, L W, Commandeur, J N M, Vermeulen, N P E & van Bladeren, P J 1996, ' In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate. ', Biochemical Pharmacology, vol. 52, pp. 197-204 . https://doi.org/10.1016/0006-2952(96)00142-6
Biochemical Pharmacology 52 (1996)
Biochemical Pharmacology, 52, 197-204
Biochemical Pharmacology, 2, 52, 197-204
Biochemical Pharmacology, 52, 197-204. Elsevier Inc.
Biochemical Pharmacology 52 (1996)
Biochemical Pharmacology, 52, 197-204
Biochemical Pharmacology, 2, 52, 197-204
Biochemical Pharmacology, 52, 197-204. Elsevier Inc.
The drug disulfiram (DSF, Antabuse) has been used in the therapy of alcohol abuse. It is a potent inhibitor of aldehyde dehydrogenase. Its reduced form, diethyldithiocarbamate (DDTC), and further metabolites show similar activities. DSF and DDTC have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1019d53dec0451bc9dd5ff4571a6233
https://research.vu.nl/en/publications/db901fc4-3409-471c-967d-6d4b148ab51a
https://research.vu.nl/en/publications/db901fc4-3409-471c-967d-6d4b148ab51a