Výsledky vyhledávání - "J.G.M. Van Engelen"

Role of biokinetics in risk assessment of drugs and chemicals in children

Autor: Adriënne J.A.M. Sips, H.E.M.G. Haenen, Carolien H.M. Versantvoort, Gerrit Wolterink, J.G.M. van Engelen, L.L. de Zwart

Publikováno v: Regulatory Toxicology and Pharmacology. 39:282-309

Whether children incur different risks from xenobiotics than adults will depend on the exposure, biokinetics, and dynamics of compound. In this paper, current knowledge on developmental physiology and possible effects on biokinetics are evaluated and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa978e8fc3c3544defffc638ef1d93fb
https://doi.org/10.1016/j.yrtph.2004.02.006

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Crossing the river stone by stone: approaches for residential risk assessment for consumers

Autor: M.T.M. van Raaij, J.G.M. van Engelen, M.P. van Veen

Publikováno v: The Annals of Occupational Hygiene. 45:S107-S118

Consumer products may contain constituents that warrant a risk analysis if they raise toxicological concern. Risk assessments are performed a priori, e.g. for pesticides and biocides, and a posteriori, to diagnose risks of contaminants. An overview i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486e88ea0d0be988f48a31c4d824f8aa
https://doi.org/10.1016/s0003-4878(00)00101-0

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Does EU legislation allow the use of the Benchmark Dose (BMD) approach for risk assessment?

Autor: A.S. Bulder, M.J. Zeilmaker, J.G.M. Bessems, W.C. Mennes, Esther Brandon, Wout Slob, Gerrit Wolterink, C.M. Mahieu, A.G. Rietveld, S.E.C.G. ten Voorde, J.G.M. van Engelen, M.E.J. Pronk, B.M. van de Ven

Publikováno v: Regulatory toxicology and pharmacology : RTP. 67(2)

Hazard characterisation is largely based on an approach of (statistically) comparing dose groups with the controls in order to derive points of departure such as no-observed-adverse-effect levels (NOAELs) or lowest-observed-adverse-effect levels (LOA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2791996345c300fc343359c1fe7777e
https://pubmed.ncbi.nlm.nih.gov/23871753

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First tier modeling of consumer dermal exposure to substances in consumer articles under REACH: a quantitative evaluation of the ECETOC TRA for consumers tool

Autor: J.G.M. van Engelen, Bas Bokkers, J.E. Delmaar, W. ter Burg

Publikováno v: Regulatory toxicology and pharmacology : RTP. 65(1)

The demonstration of safe use of chemicals in consumer products, as required under REACH, is proposed to follow a tiered process. In the first tier, simple conservative methods and assumptions should be made to quickly verify whether risks for a part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1248ef13a034492000f867229526671
https://pubmed.ncbi.nlm.nih.gov/23159863

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Human Exposure Assessement

Autor: M.G.J. Rikken, C. Money, J.G.M. Van Engelen, Pertti J. Hakkinen, Theo Vermeire

Publikováno v: Risk Assessment of Chemicals ISBN: 9781402061011

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66013eab24be7e7da6aa74abc3bc1cb0
https://doi.org/10.1007/978-1-4020-6102-8_5

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Risk assessment of chemicals and pharmaceuticals in the pediatric population: a workshop report

Autor: Adriënne J.A.M. Sips, Hana R. Pohl, J. Wilson, J.G.M. van Engelen

Publikováno v: Regulatory toxicology and pharmacology : RTP. 42(1)

ATSDR and RIVM organized an Expert Panel Workshop on the Differences Between Children and Adults and Their Relevance to Risk Assessment. The workshop was held in June 2003, in Brussels, Belgium. The purpose of the workshop was to identify data gaps i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a0fd8526c9eb25817cc30031f104c3
https://pubmed.ncbi.nlm.nih.gov/15896447

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