Zobrazeno 1 - 10
of 64
pro vyhledávání: '"J.G. Topliss"'
Autor:
M. Chorghade, N. Koga, C. G. Wermuth, T.J. Perun, Charon Robin Ganellin, Paul W. Erhardt, J.G. Topliss, P. Lindberg, B.K. Trivedi, Antonio Monge
Publikováno v:
European Journal of Medicinal Chemistry. 35:1121-1125
This document has been elaborated by the IUPAC Medicinal Chemistry section and is backed by a large number of scientists, many of whom have had direct involvement and whose names appear at the end of the article. This work discusses the role that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b4c32d6298efa993c4cedd3a69dde4
https://doi.org/10.1016/s0223-5234(00)01196-x
https://doi.org/10.1016/s0223-5234(00)01196-x
Autor:
J.G. Topliss, Fumitaka Yoshida
Publikováno v:
Journal of Medicinal Chemistry. 43:2575-2585
The quantitative structure-bioavailability relationship of 232 structurally diverse drugs was studied to evaluate the feasibility of constructing a predictive model for the human oral bioavailability of prospective new medicinal agents. The oral bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70db90c576ed253753823e1341072371
https://doi.org/10.1021/jm0000564
https://doi.org/10.1021/jm0000564
Publikováno v:
Medicinal Research Reviews. 18:121-137
The present state of faculties, student bodies, and curricula in departments of medicinal chemistry have been surveyed by questionnaire and analyzed in the context of perceptions of quality and content. The results reveal a healthy diversity of educa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd3b5d75c430b69693ebc583490e2cc
https://doi.org/10.1002/(sici)1098-1128(199803)18:2<121::aid-med2>3.0.co
https://doi.org/10.1002/(sici)1098-1128(199803)18:2<121::aid-med2>3.0.co
Publikováno v:
Journal of Computer-Aided Molecular Design. 12:441-449
The assembly of large compound libraries for the purpose of screening against various receptor targets to identify chemical leads for drug discovery programs has created a need for methods to measure the molecular diversity of such libraries. The met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c729c20d44c852740df3b6a538029af7
https://doi.org/10.1023/a:1008023429373
https://doi.org/10.1023/a:1008023429373
Autor:
J.G. Topliss, Fumitaka Yoshida
Publikováno v:
Journal of Pharmaceutical Sciences. 85:819-823
Corneal permeability data taken from the literature were analyzed for possible quantitative relationships with physicochemical properties. Although a parabolic relationship was obtained with good correlation between lipophilicity, as expressed by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2300a6de96391ede93c7649c6372962
https://doi.org/10.1021/js960076m
https://doi.org/10.1021/js960076m
Autor:
J.G. Topliss
Publikováno v:
Perspectives in Drug Discovery and Design. 1:253-268
SUMMARY Classical QSAR began almost 30 years ago. This article briefly traces its development, use and impact in relation to drug design and medicinal chemistry. Particular aspects discussed include hydrophobicity, relative potency in a series, tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d88bef13d98c942b1b42d0ed1b8dbefc
https://doi.org/10.1007/bf02174527
https://doi.org/10.1007/bf02174527
Autor:
M. Chorghade, N. Koga, Paul W. Erhardt, Antonio Monge, C.G. Wermunth, T.J. Perun, J.G. Topliss, Charon Robin Ganellin, B.K. Trivedi, P. Lindberg
Publikováno v:
Boletín de la Sociedad Chilena de Química v.46 n.2 2001
SciELO Chile
CONICYT Chile
instacron:CONICYT
Boletín de la Sociedad Chilena de Química, Volume: 46, Issue: 2, Pages: 143-148, Published: JUN 2001
SciELO Chile
CONICYT Chile
instacron:CONICYT
Boletín de la Sociedad Chilena de Química, Volume: 46, Issue: 2, Pages: 143-148, Published: JUN 2001
This document has been prepared by the IUPAC Medicinal Chemistry section and is backed by a large number of scientists, many of whom have had direct involvement and whose names appear at the end of the article. This work discusses the role that the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dc47e3385703822c96b8c726333338
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000200007
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000200007
Autor:
Bernd Clement, E. Kyburz, Antonio Monge, J.G. Topliss, Lester A. Mitscher, Olivier Lafont, Charon Robin Ganellin, A. Marcincal, T.-H. Kobayashi, Giorgio Tarzia
Publikováno v:
European journal of medicinal chemistry. 35(1)
Medicinal chemists are mainly taught in faculties or schools of pharmacy and are available for employment. Yet major pharmaceutical research companies seek organic chemists, rather than medicinal chemists, for new drug discovery. This apparent contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5aa239185813f9112998e525222ff49
https://pubmed.ncbi.nlm.nih.gov/10733613
https://pubmed.ncbi.nlm.nih.gov/10733613
Publisher Summary Many prospective chemist employees are recruited to become industrial medicinal chemists with scant prior exposure to the field itself or to biology. When it comes to hiring such chemists, the pharmaceutical employer generally seeks
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4d837324b5c53560b3462ebae90131
https://doi.org/10.1016/s0065-7743(08)60946-x
https://doi.org/10.1016/s0065-7743(08)60946-x
Autor:
Richard M. Taylor, J.G. Topliss
Publikováno v:
Journal of medicinal and pharmaceutical chemistry. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93269e33aac0c1cfd991d59edc63280
https://pubmed.ncbi.nlm.nih.gov/14051907
https://pubmed.ncbi.nlm.nih.gov/14051907