Výsledky vyhledávání

Akademický článek

Co-Occurring Methylenetetrahydrofolate Reductase (MTHFR) rs1801133 and rs1801131 Genotypes as Associative Genetic Modifiers of Clinical Severity in Rett Syndrome.

Autor: Singh, Jatinder^1,2,3 (AUTHOR) jatinder.singh@kcl.ac.uk, Wilkins, Georgina^1,2,3 (AUTHOR) georgina.e.wilkins@kcl.ac.uk, Goodman-Vincent, Ella^1,2,3 (AUTHOR) ella.goodman-vincent@kcl.ac.uk, Chishti, Samiya^1,2,3 (AUTHOR) samiya.chishti@slam.nhs.uk, Bonilla Guerrero, Ruben⁴ (AUTHOR) ruben@geneticaconsulting.com, McFadden, Leighton^1,2,3 (AUTHOR) leighton.mcfadden@kcl.ac.uk, Zahavi, Zvi⁵ (AUTHOR) zahavi@myogenes.com, Santosh, Paramala^1,2,3 (AUTHOR) paramala.1.santosh@kcl.ac.uk

Publikováno v: Brain Sciences (2076-3425). Jul2024, Vol. 14 Issue 7, p624. 15p.

Zobrazit plný text záznamu

Plný text ve formátu HTML

Improving therapeutic agents through protein engineering

Autor: R. A. G. Smith, D. W. Cronk, C. Entwisle, S. Wilson, J. H. Robinson, S. B. Kalindjian, C.G. Chapman, G.M.P. Lawrence, P. D. Chamberlain, M.J. Browne, A.F. Esmail, L. McMurdo, J.E. Carey, I. Dodd, D.L. Mitchell

Publikováno v: Journal of Chemical Technology & Biotechnology. 57:286-287

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa715c48749cc80dcde6ddb2e77f1f9
https://doi.org/10.1002/jctb.280570317

Zobrazit plný text záznamu

A recombinant, chimeric enzyme with a novel mechanism of action leading to greater potency and selectivity than tissue-type plasminogen activator

Autor: Ian B. Dodd, A.F. Esmail, J.E. Carey, S. B. Kalindjian, C. Entwisle, J H Robinson, P. D. Chamberlain, C.G. Chapman, M J Browne, D. W. Cronk

Publikováno v: Circulation. 86(2)

BACKGROUND Early intervention with thrombolytic agents has been shown unequivocally to reduce mortality after acute myocardial infarction. Presently used agents have disadvantages such as short half-life, immunogenicity, hypotension, and bleeding com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928934490922f4d938e7e68dfb23588a
https://pubmed.ncbi.nlm.nih.gov/1638720

Zobrazit plný text záznamu

The Expression of Tissue-Type Plasminogen Activator and Related Enzymes

Autor: M.J. Browne, I. Dodd, J.E. Carey, C.G. Chapman, J. H. Robinson, G.M.P. Lawrence

Publikováno v: Protein Production by Biotechnology ISBN: 9781461288589

Acute myocardial infarction (AMI) is a major cause of death in the Western World (Table 1). One of the main precipitating events in AMI is the formation of an occluding thrombus in a coronary artery. The thrombus prevents blood flow to the myocardium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30acc84875fbf29aca180c3539b76966
https://doi.org/10.1007/978-1-4613-1565-0_8

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Identification of an Intravenous Injectable NK1 Receptor Antagonist for Use in Traumatic Brain Injury.

Autor: Vink, Robert¹ (AUTHOR) robert.vink@unisa.edu.au, Nimmo, Alan² (AUTHOR) alan.nimmo@jcu.edu.au

Publikováno v: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3535. 18p.

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Binge-like Alcohol Administration Alters Decision Making in an Adolescent Rat Model: Role of N-Methyl-D-Aspartate Receptor Signaling.

Autor: Arce, Camila^1,2 cqarce@uc.cl, Mira, Rodrigo G.^1,2, Lira, Matías¹, Cerpa, Waldo^1,2,3 wcerpa@bio.puc.cl

Publikováno v: Stresses. Mar2024, Vol. 4 Issue 1, p1-13. 13p.

Zobrazit plný text záznamu

Plný text ve formátu HTML

A tissue-type plasminogen activator mutant with prolonged clearance in vivo. Effect of removal of the growth factor domain

Autor: J H Robinson, C. Entwisle, G.M.P. Lawrence, C.G. Chapman, A.W.R. Tyrrell, M.J. Browne, B. Reavy, Ian B. Dodd, A.F. Esmail, J.E. Carey

Publikováno v: Journal of Biological Chemistry. 263:1599-1602

The complete cDNA for human tissue-type plasminogen activator (t-PA) was cloned and sequenced. A mutant was constructed by using in vitro site-specific mutagenesis to delete the region encoding the growth factor domain (amino acids 51-87 inclusive).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cddcdecab7dc3551cbe16f1457c67ef
https://doi.org/10.1016/s0021-9258(19)77918-6

Zobrazit plný text záznamu