Zobrazeno 1 - 10 of 71 pro vyhledávání: '"J.E Snawder"'
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Akademický článek
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2
CHARACTERIZATION OF CYTOCHROME P450-DEPENDENT AND GLUTATHIONE TRANSFERASE ACTIVITIES IN SV40-IMMORTALIZED UROEPITHELIAL CELL LINES: POSSIBLE ROLE IN TRANSFORMATION AND TUMOR FORMATION
Autor: Santhanam Swaminathan, Susan M. Frederickson, Russell E. Savage, Catherine A. Reznikoff, J.E. Snawder
Publikováno v: Toxicology Methods. 10:195-201
An in vitro/in vivo transformation system has been developed as a model for bladder tumorigenesis. SV40-immortalized human uroepithelial cells are exposed to putative carcinogens and then implanted into athymic nude mice to testfortumorigenesis.Studi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbfdef0abf4aa1dec3b13cc9d38fcea7
https://doi.org/10.1080/10517230050121606
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3
INHIBITION OF RABBIT RENAL ORNITHINE DECARBOXYLASE ACTIVITY BY LEAD
Autor: H. Zhu, J.E. Snawder, Russell E. Savage, William J. Moorman, J.C. Clark
Publikováno v: Toxicology Methods. 9:125-136
Ornithine decarboxylase (ODC) is the first and the rate-limiting enzyme in polyamine biosynthesis. Polyamines play key roles in cell proliferation, renal membrane transportation, and plasma membrane calcium fluxes. As part of a multidisciplinary rese
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad98766aa59affad140e5982f8566e1
https://doi.org/10.1080/105172399242645
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4
Occupational Applications of a Human Cancer Research Model
Autor: Butler Ma, Russell E. Savage, Kanitz Mh, Cheever K, J.E. Snawder, Dwight Werren, Reid T, Swaminathan S, DeBord Dg
Publikováno v: Journal of Occupational & Environmental Medicine. 40:125-135
Many bladder cancers are indolent, and since there are no biomarkers to predict progression, the prognosis is problematic. Utilizing an in vitro/in vivo human uroepithelial cell (SV-HUC.PC) transformation system, we investigated several molecular eve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a0c5025f97267db6af477878fdb136
https://doi.org/10.1097/00043764-199802000-00008
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5
Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl–DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation
Autor: Jackson O. Lay, Fred F. Kadlubar, L.S. Von Tungeln, Glenn Talaska, Dean W. Roberts, Peter P. Fu, Candee H. Teitel, J.E Snawder, Sandra J. Culp, Nicholas P. Lang
Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 378:97-112
4-Aminobiphenyl (ABP) is a recognized human bladder carcinogen, whose presence in cigarette smoke results in DNA adduct formation in the human urothelium. Since preliminary studies indicated that even higher levels of ABP–DNA adducts may be present
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf395d707e1e0ea7b8bc3bfc6d5fd94f
https://doi.org/10.1016/s0027-5107(97)00101-2
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7
Osteolathyrogenic Effects of Malathion in Xenopus Embryos
Autor: Janice E. Chambers, J.E. Snawder
Publikováno v: Toxicology and Applied Pharmacology. 121:210-216
Malathion, an organophosphorus insecticide, has been found previously to cause developmental defects such as enlargement of the atria and aorta and bent notochord in Xenopus laevis . Since these defects are similar to those caused by known lathyrogen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1269f461ba92b1e8325f38870911d2e2
https://doi.org/10.1006/taap.1993.1147
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8
The effect of propylene glycol on the P450-dependent metabolism of acetaminophen and other chemicals in subcellular fractions of mouse liver
Autor: J.E.A. Leakey, R.W. Benson, Dean W. Roberts, J.E. Snawder
Publikováno v: Life Sciences. 52:183-189
Propylene glycol (PG) decreases the hepatotoxicity of acetaminophen (APAP). To elucidate the mechanism for this response, we measured the effect of PG on the in vitro metabolism of APAP by subcellular liver fractions from 6-10 week-old male B6C3F1 mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ba25378682be7e962a914f014d8997
https://doi.org/10.1016/0024-3205(93)90138-s
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9
Akademický článek
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10
Loss of CYP2E1 and CYP1A2 activity as a function of acetaminophen dose: relation to toxicity
Autor: J.E. Snawder, Amy L. Roe, D.W. Roberts, R.W. Benson
Publikováno v: Biochemical and biophysical research communications. 203(1)
The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dcaa05d44221b7c75f6b25f9727ad6
https://pubmed.ncbi.nlm.nih.gov/8074700
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