Výsledky vyhledávání - "J.Dean Farmer"

DNA binding properties of a new class of linked anthramycin analogs

Autor: Andrea Conti, Gary Gustafson, Matthew B. Zimmt, J.Dean Farmer, J. William Suggs

Publikováno v: Nucleic Acids Research. 19:899-903

We have investigated the DNA binding properties of the anthramycin analogues 4, 5, and 6 using fluorescence spectroscopy. A considerable fluorescence enhancement occurs when pyrrolo [1,4] benzodiazepines (P[1,4]Bs) are covalently attached to duplex D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78e9a5161bce9386314529ef291f812
https://doi.org/10.1093/nar/19.4.899

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Synthesis and dna crosslinking ability of a dimeric anthramycin analog

Autor: Suzanne M. Rudnicki, J.Dean Farmer, J. William Suggs

Publikováno v: Tetrahedron Letters. 29:5105-5108

Linked analogs of the DNA binding antibiotic anthramycin are made via nucleophilic aromatic substitution followed by reduction-cyclization. The linked compounds protect DNA from restriction endonucleases and reversibly crosslink DNA.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5133129dd933bbdc356ada20cfa84ec3
https://doi.org/10.1016/s0040-4039(00)80691-7

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