Výsledky vyhledávání - "J.D. Patrone"

Discovery of Protein–Protein Interaction Inhibitors of Replication Protein A

Autor: Feldkamp, Alex G. Waterson, J.P. Kennedy, N.F. Pelz, Bhavatarini Vangamudi, J.D. Patrone, Olivia W. Rossanese, Andreas O. Frank, Stephen W. Fesik, Walter J. Chazin

Publikováno v: ACS Medicinal Chemistry Letters. 4:601-605

Replication Protein A (RPA) is a ssDNA binding protein that is essential for DNA replication and repair. The initiation of the DNA damage response by RPA is mediated by protein-protein interactions involving the N-terminal domain of the 70 kDa subuni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c6a11016066953b73cc2926ef5d33c
https://doi.org/10.1021/ml400032y

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Recent advancements in the discovery of protein–protein interaction inhibitors of replication protein A† †The authors declare no competing interests

Autor: Alex G. Waterson, J.D. Patrone, Stephen W. Fesik

Due to the relatively high rate of DNA damage that can occur during cell cycle progression, the DNA damage response (DDR) pathway is critical for the survival of eukaryotic cells. Replication protein A (RPA) is an essential cell cycle checkpoint prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758f42442bd4626ab695f89e78c3f0fd
https://europepmc.org/articles/PMC6071986/

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Diphenylpyrazoles as replication protein a inhibitors

Autor: Alex G. Waterson, J. Phillip Kennedy, Stephen W. Fesik, Walter J. Chazin, Michael D. Feldkamp, Andreas O. Frank, Elaine M. Souza-Fagundes, Olivia W. Rossanese, J.D. Patrone, N.F. Pelz, Bhavatarini Vangamudi

Publikováno v: ACS medicinal chemistry letters. 6(2)

Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71108af639b404bd369d62eb1502eca7
https://pubmed.ncbi.nlm.nih.gov/25699140

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Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach

Autor: Alex G. Waterson, DeMarco V. Camper, Stephen W. Fesik, Bhavatarini Vangamudi, Olivia W. Rossanese, J.P. Kennedy, Walter J. Chazin, Andreas O. Frank, N.F. Pelz, J.D. Patrone, Feldkamp

Publikováno v: Journal of medicinal chemistry. 56(22)

Replication protein A (RPA), the major eukaryotic single-stranded DNA (ssDNA)-binding protein, is involved in nearly all cellular DNA transactions. The RPA N-terminal domain (RPA70N) is a recruitment site for proteins involved in DNA-damage response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68045f4bf11d5ff23d2e4dc6a47d6cb
https://pubmed.ncbi.nlm.nih.gov/24147804

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Surface reengineering of RPA70N enables cocrystallization with an inhibitor of the replication protein A interaction motif of ATR interacting protein

Autor: Michael D. Feldkamp, Andreas O. Frank, Walter J. Chazin, Alex G. Waterson, Bhavatarini Vangamudi, Stephen W. Fesik, J. Phillip Kennedy, J.D. Patrone

Publikováno v: Biochemistry. 52(37)

Replication protein A (RPA) is the primary single-stranded DNA (ssDNA) binding protein in eukaryotes. The N-terminal domain of the RPA70 subunit (RPA70N) interacts via a basic cleft with a wide range of DNA processing proteins, including several that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af058e3551422dfbb818c630af0d44b3
https://pubmed.ncbi.nlm.nih.gov/23962067

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Abstract 2473: Fragment-based discovery of inhibitors of replication protein A protein-protein interactions

Autor: Alex G. Waterson, Andreas O. Frank, Olivia W. Rossanese, Michael D. Feldkamp, Walter J. Chazin, Elaine M. Souza-Fagundes, J. Phillip Kennedy, Stephen W. Fesik, N.F. Pelz, J.D. Patrone, Bhavatarini Vandgamudi

Publikováno v: Cancer Research. 73:2473-2473

Replication Protein A (RPA) is a heterotrimeric protein that binds to and protects ssDNA and plays an integral role in initiating the cellular response to DNA damage. This response is mediated via protein-protein interactions between a basic cleft on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f9df6326b1581e77d8999073a876ec4
https://doi.org/10.1158/1538-7445.am2013-2473

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