Zobrazeno 1 - 10
of 14
pro vyhledávání: '"J.C.S. (Jos) Kleinjans"'
Autor:
J.C.S. (Jos) Kleinjans, E. Smit, T. van den Beucken, Jarno E J Wolters, Yannick Schrooders, Florian Caiment
Publikováno v:
Archives of Toxicology, 94(10), 3463-3473. Springer
Archives of Toxicology
Archives of Toxicology
Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2264e895e90bf5edc397ca999ca4be7a
https://cris.maastrichtuniversity.nl/en/publications/9ab1a694-19a2-48d7-b579-6a5b1d5c985f
https://cris.maastrichtuniversity.nl/en/publications/9ab1a694-19a2-48d7-b579-6a5b1d5c985f
Autor:
Terezinha de Souza, Danyel Jennen, Twan van den Beucken, J.C.S. (Jos) Kleinjans, Linda Rieswijk
Publikováno v:
Toxicology, 375, 58-63. Elsevier Ireland Ltd
Chemical carcinogenesis, albeit complex, often relies on modulation of transcription through activation or repression of key transcription factors. While analyzing extensive networks may hinder the biological interpretation, one may focus on dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c2d71cf6bfda70a947144d5ce46faa
https://cris.maastrichtuniversity.nl/en/publications/ac4d2552-ec71-4e5e-8535-236ae8ab28b7
https://cris.maastrichtuniversity.nl/en/publications/ac4d2552-ec71-4e5e-8535-236ae8ab28b7
Publikováno v:
Toxicology in Vitro, 29(5), 845-855. Elsevier Science
Imbalance between high reactive oxygen species formation and antioxidant capacity in the colon and liver has been linked to increased cancer risk. However, knowledge about possible cell line-specific oxidative stress-mechanisms is limited. To explore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55079eff2d90951cc9fb8745a3edd054
https://doi.org/10.1016/j.tiv.2015.03.007
https://doi.org/10.1016/j.tiv.2015.03.007
Publikováno v:
Toxicology Letters. 295:S217
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819f91703da64fc921ccb3e5c4b5d6c8
https://doi.org/10.1016/j.toxlet.2018.06.934
https://doi.org/10.1016/j.toxlet.2018.06.934
Publikováno v:
Toxicology Letters. 295:S158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fa76b4a318158869fbcc90a385d1523
https://doi.org/10.1016/j.toxlet.2018.06.771
https://doi.org/10.1016/j.toxlet.2018.06.771
Publikováno v:
Toxicology Letters. 258:S241-S242
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6ce5cd61821ebcda660eb2480d5e9c
https://doi.org/10.1016/j.toxlet.2016.06.1860
https://doi.org/10.1016/j.toxlet.2016.06.1860
Autor:
Shelli J. Schomaker, Florian Caiment, Deborah A. Burt, J.C.S. (Jos) Kleinjans, Roscoe L. Warner, Sandra M. Claessen, Jiri Aubrecht, Julian Krauskopf, Kent J. Johnson
Publikováno v:
Toxicological Sciences, 143(2), 268-276. Oxford University Press
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and the major reason for withdrawal of drugs from the market. Preclinical evaluation of drug candidates has failed to detect about 40% of potentially hepatotoxic compounds in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335fdeb7df9ce1685dda7b4574bf2581
https://pubmed.ncbi.nlm.nih.gov/25359176
https://pubmed.ncbi.nlm.nih.gov/25359176
Autor:
Theo M. de Kok, J.C.S. (Jos) Kleinjans, Simone G. J. van Breda, Florian Caiment, Sandra M.H. Claessen, Jarno E J Wolters
Publikováno v:
Toxicology Letters. 258:S278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9650b267abc8e170ec5f49dffd02ef2a
https://doi.org/10.1016/j.toxlet.2016.06.1972
https://doi.org/10.1016/j.toxlet.2016.06.1972
Autor:
Soterios A. Kyrtopoulos, Patricia A. McKinney, Janet E Cade, S.G.J. van Breda, Lorna K Fraser, S. J. Hepworth, Maria Botsivali, Victoria J. Burley, T. de Kok, J.C.S. (Jos) Kleinjans
Publikováno v:
Proceedings of the Nutrition Society. 69
specific dietary patterns which were derived from the analysis of food frequency questionnaire data collected at the study baseline. Using dietary data from 35 372 cohort participants, the mean intake of AA was estimated as 0.253 mg/kg/d (95% CI 0.25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eae8d7a23a5fad2b85b557d368af20d
https://doi.org/10.1017/s0029665110003629
https://doi.org/10.1017/s0029665110003629
Publikováno v:
BMJ. :h4501
Jos Kleinjans and colleagues summarise the evidence from a European study using biomarkers to assess how maternal diet affects the child Cancer in childhood is rare. Globally, there are around 175 000 new cancer cases a year among children aged 0-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6deb5dd4d516f768746c92627311a786
https://doi.org/10.1136/bmj.h4501
https://doi.org/10.1136/bmj.h4501