Zobrazeno 1 - 10
of 212
pro vyhledávání: '"J.C. Verhoef"'
Autor:
Gerrit Borchard, Farid Abedin Dorkoosh, Hans E. Junginger, D. Blok, Morteza Rafiee-Tehrani, M.P.M. Stokkel, J.C. Verhoef
Publikováno v:
Journal of Controlled Release. 99:199-206
In recent years, many complex oral drug delivery systems have been developed using various polymers in order to achieve better drug targeting and drug absorption in the intestinal tract. Superporous hydrogel (SPH) and SPH composite (SPHC)-based drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd8afdce6678eb97ae8b6ea7309895e
https://doi.org/10.1016/j.jconrel.2004.06.012
https://doi.org/10.1016/j.jconrel.2004.06.012
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 57:77-83
N-Trimethyl chitosan chloride (TMC) is a soluble chitosan derivative that shows effective enhancing properties for peptide and protein drug transport across mucosal membranes. TMC was synthesized by reductive methylation of chitosan in an alkaline en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b829928b9d10957243923942b2201e71
https://doi.org/10.1016/s0939-6411(03)00151-6
https://doi.org/10.1016/s0939-6411(03)00151-6
Autor:
J.C. Verhoef, Farid Abedin Dorkoosh, Morteza Rafiee-Tehrani, Hans E. Junginger, Jos H. M. Verheijden, Gerrit Borchard
Publikováno v:
International Journal of Pharmaceutics. 247:47-55
In this in vivo study, novel delivery systems based on superporous hydrogel (SPH) and SPH composite (SPHC) polymers were used to improve the intestinal absorption of insulin in healthy pigs. Six female pigs of approximately 35 kg body weight were use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2d5e94f8380fe4d4529b8a4f52b322
https://doi.org/10.1016/s0378-5173(02)00361-7
https://doi.org/10.1016/s0378-5173(02)00361-7
Publikováno v:
Advanced Drug Delivery Reviews. 52:139-144
The striking advantage of mucosal vaccination is the production of local antibodies at the sites where pathogens enter the body. Because vaccines alone are not sufficiently taken up after mucosal administration, they need to be co-administered with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30a44ec7f81490751120fc90b8a321b
https://doi.org/10.1016/s0169-409x(01)00197-1
https://doi.org/10.1016/s0169-409x(01)00197-1
Autor:
Morteza Rafiee-Tehrani, Hans E. Junginger, J.C. Verhoef, Farid Abedin Dorkoosh, Gerrit Borchard
Publikováno v:
Journal of Controlled Release. 71:307-318
Novel drug delivery systems were developed for peroral administration of peptide and protein drugs for site specific mechanical fixation at the gut wall and with specific release patterns. These so-called shuttle systems were designed by using superp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfad13d35d21859e34c2961035968b9c
https://doi.org/10.1016/s0168-3659(01)00232-2
https://doi.org/10.1016/s0168-3659(01)00232-2
Publikováno v:
Journal of Pharmaceutical Sciences. 90:38-46
The synthesis and evaluation of mono-N-carboxymethyl chitosan (MCC) as an intestinal permeation enhancer for macromolecular therapeutics is presented. MCCs were synthesized from two different viscosity grade chitosans to yield both high and low visco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e76eef01ea8bb3765ba1fc08104328
https://doi.org/10.1002/1520-6017(200101)90:1<38::aid-jps5>3.3.co
https://doi.org/10.1002/1520-6017(200101)90:1<38::aid-jps5>3.3.co
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 692:227-232
A rapid, selective and sensitive method for the determination of dihydroergotamine (DHE) in serum was developed. Dihydroergocristine (DHEC) was used as an internal standard. Human and rabbit serum samples were extracted using commercial solid-phase c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151567a1440f0a9458f1fd7bbc2478c0
https://doi.org/10.1016/s0378-4347(96)00490-2
https://doi.org/10.1016/s0378-4347(96)00490-2
Autor:
H.L. Lueßen, A. G. De Boer, Claus-Michael Lehr, J.C. Verhoef, Hans E. Junginger, A.F Kotzé, C.-O. Rentel
Publikováno v:
Journal of Controlled Release. 45:15-23
The purpose of the study was to evaluate the inhibitory effect of the mucoadhesive polymers polycarbophil, chitosan and chitosan glutamate on trypsin and carboxypeptidase B (CPB) activity as well as their potential to improve the intestinal transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e68707484414ef8ce4390bc75c0bf0c
https://doi.org/10.1016/s0168-3659(96)01536-2
https://doi.org/10.1016/s0168-3659(96)01536-2
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 43:43-50
The effects of current density on the temperature dependence of the electrical properties of human stratum corneum were investigated in vitro at two different current densities: 13 and 130 μA cm −2 . To obtain information on the structural basis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce6a5fd32b5640a81e32ce29c1379587
https://doi.org/10.1016/s0939-6411(96)00007-0
https://doi.org/10.1016/s0939-6411(96)00007-0
Publikováno v:
International Journal of Pharmaceutics. 141:151-160
The aim of the study was to determine the acute effects of nasal absorption enhancers on the morphology of the rat nasal epithelium in vivo. Examples of three classes of enhancers were studied: the cyclodextrins dimethyl-β-cyclodextrin 2% (w/v) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb00ceb8ee1bd894b9f1f07fec8afe52
https://doi.org/10.1016/0378-5173(96)04632-7
https://doi.org/10.1016/0378-5173(96)04632-7